Results 41 to 50 of about 8,630,188 (308)

The Plasma Parameters of Penning Discharge with Negatively Biased Metal Hydride Cathode at Longitudinal Emission of H– Ions

East European Journal of Physics, 2021
The enhancement of negative ion production in a volume Penning based source could be performed by the application of metal hydride cathode. Hydrogen isotopes are stored there in a chemically bound atomic state and desorbed from the metal hydride under ...
Ihor Sereda, Yaroslav Hrechko, Ievgeniia Babenko Babenko   +2 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Analysis and optimization of cesium dynamics for the HUST negative ion source

Nuclear Engineering and Technology
The high-density beam in the NBI negative ion source relies on surface production on the converter with low work function, which is facilitated by cesium injection.
Feng Xue, Chen Zuo, Dong Li, Dezhi Chen
doaj   +1 more source

Theoretical calculation of cesium deposition and co-deposition with electronegative elements on the plasma grid in negative ion sources

Nuclear Materials and Energy, 2023
We studied the work function of cesium deposition and co-deposition with the electronegative element on the plasma grid (PG) using the first-principles calculations.
Heng Li, Xin Zhang, Yuhong Xu, Guangjiu Lei, Katsuyoshi Tsumori, Mitsutaka Isobe, Akihiro Shimizu, Zilin Cui, Yiqin Zhu, Jun Hu, Yuxiang Ni, Shaofei Geng, Haifeng Liu, Xianqu Wang, Jie Huang, Hai Liu, Jun Cheng, Changjian Tang, CFQS team   +18 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Experimental and simulation study on the backstreaming positive ions on the quarter-size negative ion source for CRAFT NNBI test facility

Nuclear Engineering and Technology
As an effective methods of plasma heating, neutral beam injection (NBI) systems based on negative hydrogen ion sources will be utilized in future magnetic-confinement nuclear fusion experiments.
Yongjian Xu, Yuwen Yang, Jianglong Wei, Ling Yu, Wen Deng, Rixin Wang, Yuming Gu, Chundong Hu, Yahong Xie   +8 more
doaj   +1 more source

Negative ion research at the Culham Centre for Fusion Energy (CCFE)

New Journal of Physics, 2016
A summary of negative ion development work being presently undertaken at the Culham Centre for Fusion Energy is given. The small negative ion facility has an RF driven volume ion source with beam extraction at energies up to 30 keV. The extracted beam of
R McAdams, A J T Holmes, D B King, E Surrey, I Turner, J Zacks   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Progress of CRAFT negative ion source neutral beam injection test facility

Nuclear Fusion
The Comprehensive Research Facility for Fusion Technology (CRAFT) is a national large research infrastructure in China. CRAFT aims to develop the key technologies for future fusion reactor and the negative ion source neutral beam injection (NNBI) is one ...
Jianglong Wei, Wei Liu, Yongjian Xu, Yuming Gu, Yahong Xie, Na Wang, Bo Liu, Dmitrii Stepanov, Shengmin Pan, Zhigang Zhu, Bin Guo, Xiancai Meng, Xufeng Peng, Hao Wu, Liang Zhang, Chundong Hu, Lizhen Liang, CRAFT NNBI Team   +17 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source