This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song +9 more
wiley +1 more source
A Ticklish Affair: Tickling Impacts Play Features in Bonobos. [PDF]
Demuru E +6 more
europepmc +1 more source
F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao +9 more
wiley +1 more source
The association between social capital and mental health among older people living with HIV: a systematic review. [PDF]
Xia H, Cao X, He Y, Yang L, Yu Q.
europepmc +1 more source
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan +7 more
wiley +1 more source
Structural Divergence Between the Moltbook AI-Agent Network and Human Social Networks. [PDF]
Hou W, Ji Z.
europepmc +1 more source
Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders
BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley +1 more source
Status Threat or Grateful Reciprocity? Investigating Pathways Through Which Receiving Task-Related Help Influences Recipients' Subsequent Differentiated Helping Behavior. [PDF]
Wu H, Chen J, Si B, Xia L, Mao Y.
europepmc +1 more source
Liquid gallium (Ga) acts as a catalytic center for nitric oxide (NO) generation within a tannic acid–zirconium metal–phenolic network coating. Stabilized Ga nanoparticles catalyze S‐nitrosothiol decomposition through surface electron transfer, enabling controlled NO production, enhancing endothelial biocompatibility, and providing antioxidant and anti ...
Franco Centurion +10 more
wiley +1 more source
Understanding COVID-19 Vaccination Intention in Japan: The Influence of Individual Social Capital and Personal Beliefs on Vaccination. [PDF]
Furukawa Y +4 more
europepmc +1 more source

