Results 161 to 170 of about 4,598,204 (290)

Lysine Deacetylase Substrate Selectivity: Distinct Interaction Surfaces Drive Positive and Negative Selection for Residues Following Acetyllysine. [PDF]

Biochemistry, 2023
Toro TB, Bornes KE, Watt TJ.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Negative Selection Maintains Grossly Altered but Broadly Stable Karyotypes in Metastatic Colorectal Cancer. [PDF]

Cancer Discov
Cross WCH, Nowinski S, Cresswell GD, Mossner M, Banerjee A, Lu B, Williams MJ, Vlachogiannis G, Gay LJ, Baker AM, Kimberley C, Whiting FJH, Belnoue-Davis HL, Martinez P, Traki M, Walther V, Smith K, Fernandez-Mateos J, Yara-Romero E, Oliveira EA, Milite S, Caravagna G, James CT, Elia G, Berner A, Ryan Choi CH, Ramagiri P, Chauhan R, Matthews N, Murphy J, Antoniou A, Clark SK, Mitchison M, Chin Aleong JA, Domingo E, Spiteri I, McDonald SAC, Shibata D, Laclé MM, Wang LM, Moorghen M, Tomlinson IPM, Novelli M, Jansen M, Watson A, Valeri N, Wright NA, Bridgewater JA, Rodriguez-Justo M, Barnes CP, Kocher HM, Leedham SJ, Sottoriva A, Graham TA.   +53 more
europepmc   +1 more source

Positive and negative selection shape the human naive B cell repertoire. [PDF]

J Clin Invest, 2022
Chen JW, Schickel JN, Tsakiris N, Sng J, Arbogast F, Bouis D, Parisi D, Gera R, Boeckers JM, Delmotte FR, Veselits M, Schuetz C, Jacobsen EM, Posovszky C, Schulz AS, Schwarz K, Clark MR, Menard L, Meffre E.   +18 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

CD99-targeted immunomagnetic negative selection: A novel strategy for high-purity pancreatic islet isolation in murine models. [PDF]

PLoS One
Liu J, Li D, Huang J, Hu Y, Zhang L.
europepmc   +1 more source

I-A^g7 β56/57 polymorphisms regulate non-cognate negative selection to CD4⁺ T cell orchestrators of type 1 diabetes. [PDF]

Nat Immunol, 2023
Stadinski BD, Cleveland SB, Brehm MA, Greiner DL, Huseby PG, Huseby ES.   +5 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Fine tuning of TCR signaling via CD8αβ and PD-1 and the fate of autoreactive thymocytes during negative selection. [PDF]

Immunohorizons
Zúñiga MC, Hyun S, Du J, Dubiner S, Freedman-Goretsky A, Goretsky Y, Pothukuchi A, Fong NAY, Berg A, Davis C, Barata M, Deveau TM, Sas A, Abreo S, Kim B, Nguyen A, Schneider J, White A.   +17 more
europepmc   +1 more source

Mouse splenocyte enrichment strategies via negative selection for broadened single-cell transcriptomics. [PDF]

STAR Protoc, 2022
Schulze TT, Neville AJ, Chapman RC, Davis PH.   +3 more
europepmc   +1 more source