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CCL2 Chemokine in Central Tolerance
Scandinavian Journal of Immunology, 2014Cedile, O. +6 more
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The many faces of Aire in central tolerance [PDF]
Frontiers in Immunology, 2013 Although the role that Autoimmune Regulator (Aire) plays in the induction of central tolerance is well known, the precise cellular and molecular mechanisms are still unclear and debated.
Martti eLaan, Pärt ePeterson
doaj +7 more sources
Age-Related Changes in Thymic Central Tolerance [PDF]
Frontiers in Immunology, 2021 Thymic epithelial cells (TECs) and hematopoietic antigen presenting cells (HAPCs) in the thymus microenvironment provide essential signals to self-reactive thymocytes that induce either negative selection or generation of regulatory T cells (Treg), both ...
Jayashree Srinivasan +6 more
doaj +4 more sources
Mechanisms of central tolerance for B cells [PDF]
Nature Reviews Immunology, 2017 Immune tolerance hinders the potentially destructive responses of lymphocytes to host tissues. Tolerance is regulated at the stage of immature B cell development (central tolerance) by clonal deletion, involving apoptosis, and by receptor editing, which reprogrammes the specificity of B cells through secondary recombination of antibody genes.
David Nemazee
exaly +5 more sources
CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance [PDF]
eLife, 2023 Central tolerance ensures autoreactive T cells are eliminated or diverted to the regulatory T cell lineage, thus preventing autoimmunity. To undergo central tolerance, thymocytes must enter the medulla to test their T-cell receptors (TCRs) for ...
Yu Li +5 more
doaj +2 more sources
Central tolerance promoted by cell chimerism. [PDF]
Proc Natl Acad Sci U S A, 2022 Historically, successful allotransplantation was only achieved by utilizing powerful immunosuppressive drugs that were exposing the patient to severe opportunistic infections. The thymus of the transplant recipient renders such therapy obligatory as it constitutively blocks self-reactive T cells while allowing alloreactive T cells to mature and ...
Zeleniak A, Trucco M.
europepmc +3 more sources