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Age-Related Changes in Thymic Central Tolerance [PDF]
Frontiers in Immunology, 2021 Thymic epithelial cells (TECs) and hematopoietic antigen presenting cells (HAPCs) in the thymus microenvironment provide essential signals to self-reactive thymocytes that induce either negative selection or generation of regulatory T cells (Treg), both ...
Jayashree Srinivasan +6 more
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Mechanisms of central tolerance for B cells [PDF]
Nature Reviews Immunology, 2017 Immune tolerance hinders the potentially destructive responses of lymphocytes to host tissues. Tolerance is regulated at the stage of immature B cell development (central tolerance) by clonal deletion, involving apoptosis, and by receptor editing, which reprogrammes the specificity of B cells through secondary recombination of antibody genes.
David Nemazee, Nemazee David
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The many faces of Aire in central tolerance [PDF]
Frontiers in Immunology, 2013 Although the role that Autoimmune Regulator (Aire) plays in the induction of central tolerance is well known, the precise cellular and molecular mechanisms are still unclear and debated.
Martti eLaan, Pärt ePeterson
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CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance [PDF]
eLife, 2023 Central tolerance ensures autoreactive T cells are eliminated or diverted to the regulatory T cell lineage, thus preventing autoimmunity. To undergo central tolerance, thymocytes must enter the medulla to test their T-cell receptors (TCRs) for ...
Yu Li +5 more
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The Thymus and Central Tolerance [PDF]
Clinical Immunology, 2000 T–cell differentiation in the thymus generates a peripheral repertoire of mature T cells that mounts strong responses to foreign antigens but is largely unresponsive to self–antigens. This state of specific immunological tolerance to self–components involves both central and peripheral mechanisms.
Hidehiro Kishimoto
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T cell tolerance to the skin: a central role for central tolerance [PDF]
Seminars in Immunopathology, 2007 T cell tolerance to self-antigens is believed to be achieved in a two-step process. The first step, called central tolerance, takes place in the thymus. The second step takes place outside the thymus in secondary lymphoid organs. One may ask why two mechanisms are needed to insure T cell tolerance.
Emmanuel Contassot, Bertrand Huard
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On central max-point-tolerance graphs [PDF]
AKCE International Journal of Graphs and Combinatorics, 2020 Max-point-tolerance graphs (MPTG) were studied by Catanzaro et al. in 2017 and the same class of graphs were introduced in the name of p-BOX(1) graphs by Soto and Caro in 2015.
Sanchita Paul
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Mediators of central tolerance [PDF]
Nature Reviews Immunology, 2015 Leavy Olive
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A model of preferential pairing between epithelial and dendritic cells in thymic antigen transfer
eLife, 2022 Medullary thymic epithelial cells (mTECs), which produce and present self-antigens, are essential for the establishment of central tolerance. Since mTEC numbers are limited, their function is complemented by thymic dendritic cells (DCs), which transfer ...
Matouš Vobořil +8 more
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RANK Signaling in the Differentiation and Regeneration of Thymic Epithelial Cells
Frontiers in Immunology, 2021 Thymic epithelial cells (TECs) provide essential clues for the proliferation, survival, migration, and differentiation of thymocytes. Recent advances in mouse and human have revealed that TECs constitute a highly heterogeneous cell population with ...
Magali Irla
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