CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance [PDF]
eLife, 2023 Central tolerance ensures autoreactive T cells are eliminated or diverted to the regulatory T cell lineage, thus preventing autoimmunity. To undergo central tolerance, thymocytes must enter the medulla to test their T-cell receptors (TCRs) for ...
Yu Li +5 more
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Age-Related Changes in Thymic Central Tolerance [PDF]
Frontiers in Immunology, 2021 Thymic epithelial cells (TECs) and hematopoietic antigen presenting cells (HAPCs) in the thymus microenvironment provide essential signals to self-reactive thymocytes that induce either negative selection or generation of regulatory T cells (Treg), both ...
Jayashree Srinivasan +6 more
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Helicobacter pylori outer membrane vesicles mediate central tolerance in C57BL/6J mice offspring T cells via maternal-fetal transmission [PDF]
Frontiers in ImmunologyOuter membrane vesicles (OMVs) released by Helicobacter pylori (H.pylori) can enter the blood circulation of the host and cause extra-gastric lesions such as atherosclerosis and hyperemesis gravidarum.
Yusen Wei +7 more
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Analysis of a miR-148a Targetome in B Cell Central Tolerance [PDF]
Frontiers in Immunology, 2022 A microRNA (miRNA) often regulates the expression of hundreds of target genes. A fundamental question in the field of miRNA research is whether a miRNA exerts its biological function through regulating a small number of key targets or through small ...
Fengge Ma +8 more
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Porcine Circovirus Type 2 Pathogenicity Alters Host’s Central Tolerance for Propagation [PDF]
Pathogens, 2020 Porcine circovirus type 2 (PCV2) infections and resulting diseases are a worldwide threat to pig production. PCV2 bears a uniqueness that allows for us to understand more about chronic infections and the immune system in general.
Xaver Sidler +4 more
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High prevalence of obesity, central obesity and abnormal glucose tolerance in the middle-aged Finnish population [PDF]
BMC Public Health, 2008 Background There is a worldwide increase in the prevalence of obesity and disturbances in glucose metabolism. The aim of this study was to assess the current prevalence of obesity, central obesity and abnormal glucose tolerance in Finnish population, and
Vanhala Mauno +10 more
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RESTING SYMPATHETIC BAROREFLEX SENSITIVITY IN SUBJECTS WITH LOW AND HIGH TOLERANCE TO CENTRAL HYPOVOLEMIA INDUCED BY LOWER BODY NEGATIVE PRESSURE [PDF]
Frontiers in Physiology, 2014 Central hypovolemia elicited by orthostasis or hemorrhage triggers sympathetically-mediated baroreflex responses to maintain organ perfusion; these reflexes are less sensitive in patients with orthostatic intolerance, and during conditions of severe ...
Carmen eHinojosa-Laborde +3 more
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The many faces of Aire in central tolerance [PDF]
Frontiers in Immunology, 2013 Although the role that Autoimmune Regulator (Aire) plays in the induction of central tolerance is well known, the precise cellular and molecular mechanisms are still unclear and debated.
Martti eLaan, Pärt ePeterson
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A model of preferential pairing between epithelial and dendritic cells in thymic antigen transfer
eLife, 2022 Medullary thymic epithelial cells (mTECs), which produce and present self-antigens, are essential for the establishment of central tolerance. Since mTEC numbers are limited, their function is complemented by thymic dendritic cells (DCs), which transfer ...
Matouš Vobořil +8 more
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Thymic central tolerance takes centre stage in autoimmune disease [PDF]
The Lancet Regional Health. Western PacificSmaila Mulic-Al Bunni, Adam E. Handel
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