Results 11 to 20 of about 473,837 (287)
Age-Related Changes in Thymic Central Tolerance [PDF]
Frontiers in Immunology, 2021 Thymic epithelial cells (TECs) and hematopoietic antigen presenting cells (HAPCs) in the thymus microenvironment provide essential signals to self-reactive thymocytes that induce either negative selection or generation of regulatory T cells (Treg), both ...
Jayashree Srinivasan +6 more
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T cell tolerance to the skin: a central role for central tolerance [PDF]
Seminars in Immunopathology, 2007 T cell tolerance to self-antigens is believed to be achieved in a two-step process. The first step, called central tolerance, takes place in the thymus. The second step takes place outside the thymus in secondary lymphoid organs. One may ask why two mechanisms are needed to insure T cell tolerance.
Emmanuel Contassot, Bertrand Huard
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Analysis of a miR-148a Targetome in B Cell Central Tolerance [PDF]
Frontiers in Immunology, 2022 A microRNA (miRNA) often regulates the expression of hundreds of target genes. A fundamental question in the field of miRNA research is whether a miRNA exerts its biological function through regulating a small number of key targets or through small ...
Fengge Ma +8 more
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Mechanisms of central tolerance for B cells [PDF]
Nature Reviews Immunology, 2017 Immune tolerance hinders the potentially destructive responses of lymphocytes to host tissues. Tolerance is regulated at the stage of immature B cell development (central tolerance) by clonal deletion, involving apoptosis, and by receptor editing, which reprogrammes the specificity of B cells through secondary recombination of antibody genes.
David Nemazee, Nemazee David
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The many faces of Aire in central tolerance [PDF]
Frontiers in Immunology, 2013 Although the role that Autoimmune Regulator (Aire) plays in the induction of central tolerance is well known, the precise cellular and molecular mechanisms are still unclear and debated.
Martti eLaan, Pärt ePeterson
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CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance [PDF]
eLife, 2023 Central tolerance ensures autoreactive T cells are eliminated or diverted to the regulatory T cell lineage, thus preventing autoimmunity. To undergo central tolerance, thymocytes must enter the medulla to test their T-cell receptors (TCRs) for ...
Yu Li +5 more
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Back to Central Tolerance [PDF]
Immunity, 2004 The establishment and maintenance of immunological tolerance entails both central and peripheral mechanisms. The latter have been highlighted in the past several years, mostly because of great interest in the activities of regulatory T cells. However, an important role for central tolerance mechanisms has been reemphasized by recent results on human ...
Mathis, Diane, Benoist, Christophe
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Central Tolerance Matters [PDF]
Immunity, 2005 In this issue of Immunity, Anderson et al. provide another clue to the riddle that is Aire--why do human beings and mice lacking Aire develop diffuse and pathogenic autoimmunity? They find that Aire influences central tolerance not only by promoting the expression of peripheral self-proteins in thymic medullary epithelial cells (MECs) but also by ...
Goldrath, Ananda W., Hedrick, Stephen M.
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Central tolerance promoted by cell chimerism [PDF]
Proceedings of the National Academy of Sciences, 2022 Historically, successful allotransplantation was only achieved by utilizing powerful immunosuppressive drugs that were exposing the patient to severe opportunistic infections. The thymus of the transplant recipient renders such therapy obligatory as it constitutively blocks self-reactive T cells while allowing alloreactive T cells to mature and ...
Ann Zeleniak, Massimo Trucco
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Helicobacter pylori outer membrane vesicles mediate central tolerance in C57BL/6J mice offspring T cells via maternal-fetal transmission [PDF]
Frontiers in ImmunologyOuter membrane vesicles (OMVs) released by Helicobacter pylori (H.pylori) can enter the blood circulation of the host and cause extra-gastric lesions such as atherosclerosis and hyperemesis gravidarum.
Yusen Wei +7 more
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