Results 11 to 20 of about 448,542 (245)
Central tolerance promoted by cell chimerism [PDF]
Proceedings of the National Academy of Sciences, 2022 Historically, successful allotransplantation was only achieved by utilizing powerful immunosuppressive drugs that were exposing the patient to severe opportunistic infections. The thymus of the transplant recipient renders such therapy obligatory as it constitutively blocks self-reactive T cells while allowing alloreactive T cells to mature and ...
Ann Zeleniak, Massimo Trucco
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Helicobacter pylori outer membrane vesicles mediate central tolerance in C57BL/6J mice offspring T cells via maternal-fetal transmission [PDF]
Frontiers in ImmunologyOuter membrane vesicles (OMVs) released by Helicobacter pylori (H.pylori) can enter the blood circulation of the host and cause extra-gastric lesions such as atherosclerosis and hyperemesis gravidarum.
Yusen Wei +7 more
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Analysis of a miR-148a Targetome in B Cell Central Tolerance [PDF]
Frontiers in Immunology, 2022 A microRNA (miRNA) often regulates the expression of hundreds of target genes. A fundamental question in the field of miRNA research is whether a miRNA exerts its biological function through regulating a small number of key targets or through small ...
Fengge Ma +8 more
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Porcine Circovirus Type 2 Pathogenicity Alters Host’s Central Tolerance for Propagation [PDF]
Pathogens, 2020 Porcine circovirus type 2 (PCV2) infections and resulting diseases are a worldwide threat to pig production. PCV2 bears a uniqueness that allows for us to understand more about chronic infections and the immune system in general.
Xaver Sidler +4 more
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The Role of Dendritic Cells in Central Tolerance [PDF]
Immune Network, 2015 Dendritic cells (DCs) play a significant role in establishing self-tolerance through their ability to present self-antigens to developing T cells in the thymus. DCs are predominantly localized in the medullary region of thymus and present a broad range of self-antigens, which include tissue-restricted antigens expressed and transferred from medullary ...
Oh, Jaehak, Shin, Jeoung-Sook
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Central Tolerance or Central Adaptation? [PDF]
Scandinavian Journal of ImmunologyManjili MH.
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Molecular Therapy: Methods & Clinical Development, 2022 Insulin is the primary autoantigen (Ag) targeted by T cells in type 1 diabetes (T1D). Although biomarkers precisely identifying subjects at high risk of T1D are available, successful prophylaxis is still an unmet need.
Fabio Russo +8 more
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Central Tolerance Matters [PDF]
Immunity, 2005 In this issue of Immunity, Anderson et al. provide another clue to the riddle that is Aire--why do human beings and mice lacking Aire develop diffuse and pathogenic autoimmunity? They find that Aire influences central tolerance not only by promoting the expression of peripheral self-proteins in thymic medullary epithelial cells (MECs) but also by ...
Goldrath, Ananda W., Hedrick, Stephen M.
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Back to Central Tolerance [PDF]
Immunity, 2004 The establishment and maintenance of immunological tolerance entails both central and peripheral mechanisms. The latter have been highlighted in the past several years, mostly because of great interest in the activities of regulatory T cells. However, an important role for central tolerance mechanisms has been reemphasized by recent results on human ...
Mathis, Diane, Benoist, Christophe
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Exploring the Origin and Antigenic Specificity of Maternal Regulatory T Cells in Pregnancy
Frontiers in Immunology, 2020 Successful pregnancy outcome is partially determined by the suppression of reactive effector T cells by maternal regulatory T cells (TRegs) at the maternal-fetal interface.
Soo Hyun Ahn +5 more
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