Results 11 to 20 of about 6,990,145 (285)
Helicobacter pylori outer membrane vesicles mediate central tolerance in C57BL/6J mice offspring T cells via maternal-fetal transmission [PDF]
Frontiers in ImmunologyOuter membrane vesicles (OMVs) released by Helicobacter pylori (H.pylori) can enter the blood circulation of the host and cause extra-gastric lesions such as atherosclerosis and hyperemesis gravidarum.
Yusen Wei +7 more
doaj +2 more sources
Analysis of a miR-148a Targetome in B Cell Central Tolerance [PDF]
Frontiers in Immunology, 2022 A microRNA (miRNA) often regulates the expression of hundreds of target genes. A fundamental question in the field of miRNA research is whether a miRNA exerts its biological function through regulating a small number of key targets or through small ...
Fengge Ma +8 more
doaj +2 more sources
Porcine Circovirus Type 2 Pathogenicity Alters Host’s Central Tolerance for Propagation [PDF]
Pathogens, 2020 Porcine circovirus type 2 (PCV2) infections and resulting diseases are a worldwide threat to pig production. PCV2 bears a uniqueness that allows for us to understand more about chronic infections and the immune system in general.
Xaver Sidler +4 more
doaj +2 more sources
T cell tolerance to the skin: a central role for central tolerance [PDF]
Seminars in Immunopathology, 2007 T cell tolerance to self-antigens is believed to be achieved in a two-step process. The first step, called central tolerance, takes place in the thymus. The second step takes place outside the thymus in secondary lymphoid organs. One may ask why two mechanisms are needed to insure T cell tolerance.
Emmanuel Contassot, Bertrand Huard
exaly +3 more sources
AIRE transcriptional condensates in central tolerance: a multiscale mechanistic perspective [PDF]
Frontiers in ImmunologyAutoimmune regulator (AIRE) enables medullary thymic epithelial cells (mTECs) to express a broad but selective repertoire of tissue-restricted antigens (TRAs), thereby supporting central T-cell tolerance.
Jiejie He, Weiwei Xue, Jun Zhang, Yan Li
doaj +2 more sources
On central max-point-tolerance graphs [PDF]
AKCE International Journal of Graphs and Combinatorics, 2020 Max-point-tolerance graphs (MPTG) were studied by Catanzaro et al. in 2017 and the same class of graphs were introduced in the name of p-BOX(1) graphs by Soto and Caro in 2015.
Sanchita Paul
doaj +2 more sources
The Role of Dendritic Cells in Central Tolerance. [PDF]
Immune Netw, 2015 Dendritic cells (DCs) play a significant role in establishing self-tolerance through their ability to present self-antigens to developing T cells in the thymus. DCs are predominantly localized in the medullary region of thymus and present a broad range of self-antigens, which include tissue-restricted antigens expressed and transferred from medullary ...
Oh J, Shin JS.
europepmc +4 more sources
Thymic B cells and central T cell tolerance
Frontiers in Immunology, 2015 Central T cell tolerance is believed to be mainly induced by thymic dendritic cells and medullary thymic epithelial cells. The thymus also harbors substantial numbers of B cells.
Ludger eKlein +2 more
doaj +3 more sources
A model of preferential pairing between epithelial and dendritic cells in thymic antigen transfer
eLife, 2022 Medullary thymic epithelial cells (mTECs), which produce and present self-antigens, are essential for the establishment of central tolerance. Since mTEC numbers are limited, their function is complemented by thymic dendritic cells (DCs), which transfer ...
Matouš Vobořil +8 more
doaj +1 more source