Results 41 to 50 of about 1,365,539 (250)

A role for phagocytosis in inducing cell death during thymocyte negative selection

eLife, 2019
Autoreactive thymocytes are eliminated during negative selection in the thymus, a process important for establishing self-tolerance. Thymic phagocytes serve to remove dead thymocytes, but whether they play additional roles during negative selection ...
Nadia S Kurd, Lydia K Lutes, Jaewon Yoon, Shiao Wei Chan, Ivan L Dzhagalov, Ashley R Hoover, Ellen A Robey   +6 more
doaj   +1 more source

The deffect effect on electronic conductance in binomially tailored quantum wire [PDF]

, 2006
The paper considers the effect of the defects on the electronic transmission properties in binomially tailored waveguide quantum wires, in which each Dirac delta function potential strength have been weight on the binomial distribution law.
A.I. Assad, Baym, Ferry, H.S. Ashour, Merzbacher, Midgley   +5 more
core   +3 more sources

Design degrees of freedom and mechanisms for complexity [PDF]

, 2002
We develop a discrete spectrum of percolation forest fire models characterized by increasing design degrees of freedom (DDOF’s). The DDOF’s are tuned to optimize the yield of trees after a single spark.
Carlson, J. M., Doyle, John, Reynolds, David   +2 more
core   +1 more source

Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection

Frontiers in Immunology, 2020
The development of autoimmune disorders is incompletely understood. Inefficient thymic T cell selection against self-peptides presented by major histocompatibility antigens (HLA in humans) may contribute to the emergence of auto-reactive effector cells ...
Bernhard Loll, Christine Rückert, Barbara Uchanska-Ziegler, Barbara Uchanska-Ziegler, Andreas Ziegler   +4 more
doaj   +1 more source

Increased central artery stiffness in impaired glucose metabolism and type 2 diabetes - The Hoorn study [PDF]

, 2003
Impaired glucose metabolism (IGM) and type 2 diabetes (DM-2) are associated with high cardiovascular disease risk. Increases in peripheral and central artery stiffness may represent pathophysiologic pathways through which glucose tolerance status leads ...
Bouter, L.M., Dekker, J.M., Dijk, R.A.J.M. van, Heine, R.J., Henry, R.M.A., Kostense, P.J., Nijpels, G., Schram, M.T., Stehouwer, C.D.A., Westerhof, N.   +9 more
core   +3 more sources

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie, Kara A. Gray‐Burrows, Peter F. Day, Bob Phillips, Carl A. Thompson   +4 more
wiley   +1 more source

Genetic Polymorphisms in Exon 5 and Intron 5 and 7 of AIRE Are Associated with Rheumatoid Arthritis Risk in a Hungarian Population

Biology
Background: Rheumatoid arthritis (RA) is chronically persistent synovitis and systemic inflammation. Although multiple contributors are detected, only one is pivotal in the neonatal period: the negative selection of autoimmune naïve T-cells by the ...
Bálint Bérczi, Nóra Nusser, Iván Péter, Balázs Németh, Ágota Kulisch, Zsuzsanna Kiss, Zoltán Gyöngyi   +6 more
doaj   +1 more source

T cell tolerance to the skin: a central role for central tolerance [PDF]

, 2018
T cell tolerance to self-antigens is believed to be achieved in a two-step process. The first step, called central tolerance, takes place in the thymus. The second step takes place outside the thymus in secondary lymphoid organs.
Contassot, Emmanuel, Huard, Bertrand, Schuler, Prisca   +2 more
core  

Comparing Experiments to the Fault-Tolerance Threshold

, 2016
Achieving error rates that meet or exceed the fault-tolerance threshold is a central goal for quantum computing experiments, and measuring these error rates using randomized benchmarking is now routine.
Doherty, Andrew C., Flammia, Steven T., Kueng, Richard, Long, David M.   +3 more
core   +1 more source

What lies beneath: exploring links between asylum policy and hate crime in the UK [PDF]

, 2010
This paper explores the link between increasing incidents of hate crime and the asylum policy of successive British governments with its central emphasis on deterrence.
A Dummett, A Harmit, Administrator, B Bowling, B Perry, British Crime Survey, C Coole, Children’s Commissioner, Crown Prosecution Service, D Coleman, D Frost, D Gadd, D Kahan, DP Green, E Bleich, E Goffman, F Anthias, G Cornelisse, G Mason, G Moon, H Hurd, H O’Nions, Helen O’Nions, Home Office, Human Rights First, Human Rights First, I Dale, ICAR (Information centre about asylum seekers and refugees), Independent Asylum Commission, J Banks, L Dixon, L Fekete, L Ray, M Wetherell, N Hall, O Fiss, O Parker, OG Bailey, OSCE, P Aspinall, P Iganksi, P Tuitt, R Capdevila, R Grillo, R Karapin, R Karapin, R Sibbitt, Refugee Action, Refugee Action, S Goodman, Scottish Executive, T Bjorgo, T Bjorgo, T Bjorgo, T Cantle, T Hayter, T Veenkamp, TA Dijk Van, TA Dijk Van, UNHCR   +59 more
core   +1 more source