Results 41 to 50 of about 473,837 (287)

Role of regulatory T cells in immune tolerance [PDF]

, 2009
In this present work, we investigated the role of dendritic cells (DC) and regulatory T cells (Treg) in immune tolerance as well as their potential in the treatment of autoimmune or graft versus host (GvH) diseases.
Swee, Lee Kim
core   +1 more source

CCR7 Modulates the Generation of Thymic Regulatory T Cells by Altering the Composition of the Thymic Dendritic Cell Compartment

Cell Reports, 2017
Upon recognition of auto-antigens, thymocytes are negatively selected or diverted to a regulatory T cell (Treg) fate. CCR7 is required for negative selection of auto-reactive thymocytes in the thymic medulla.
Zicheng Hu, Yu Li, Annemarie Van Nieuwenhuijze, Hilary J. Selden, Angela M. Jarrett, Anna G. Sorace, Thomas E. Yankeelov, Adrian Liston, Lauren I.R. Ehrlich   +8 more
doaj   +1 more source

Is T Cell Negative Selection a Learning Algorithm?

Cells, 2020
Our immune system can destroy most cells in our body, an ability that needs to be tightly controlled. To prevent autoimmunity, the thymic medulla exposes developing T cells to normal “self” peptides and prevents any responders from entering ...
Inge M. N. Wortel, Can Keşmir, Rob J. de Boer, Judith N. Mandl, Johannes Textor   +4 more
doaj   +1 more source

Amphetamine and pseudoephedrine cross-tolerance measured by c-Fos protein expression in brains of chronically treated rats [PDF]

, 2008
Background Pseudoephedrine is a drug commonly prescribed as a nasal decongestant and bronchodilator and is also freely available in cold remedies and medications.
Tongjaroenbuangam, W., Nootchanart Ruksee, Govitrapong, P., Casalotti Stefano O, Ruksee Nootchanart, Walaiporn Tongjaroenbuangam, Nootchanart Ruksee, Govitrapong Piyarat, Casalotti, Stefano O., Ruksee, N., Piyarat Govitrapong, Tongjaroenbuangam Walaiporn, Stefano O Casalotti   +12 more
core   +1 more source

CCR4 promotes medullary entry and thymocyte–dendritic cell interactions required for central tolerance [PDF]

Journal of Experimental Medicine, 2015
Lauren Ehrlich, Jessica Lancaster
exaly   +2 more sources

Damage Tolerance and Fail Safety of Welded Aircraft Wing Panels [PDF]

, 2005
An investigation is presented on fatigue crack growth behavior and fail safety of integral stringer panels typified by welded aircraft fabrications. The stringer panel is made of aluminum alloy 2024-T351 and fabricated by the variable-polarity plasma-arc
Zhang, Xiang, Li, Yazhi
core   +1 more source

Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection [PDF]

, 2008
Autoimmune liver diseases, such as autoimmune hepatitis (AIH) and primary biliary cirrhosis, often have severe consequences for the patient. Because of a lack of appropriate animal models, not much is known about their potential viral etiology. Infection
Hintereder, Gudrun, Gudrun Hintereder, Michael P. Manns, Christen, Urs, Herrath, Matthias G. von, Holdener, Martin, Monika Bayer, Johnson, Eric F., Urs Christen, Rodrigo, Evelyn, Frank J. Gonzalez, Pfeilschifter, Josef (Prof. Dr.), Eric F. Johnson, Evelyn Rodrigo, Gonzalez, Frank J., Martin Holdener, Edith Hintermann, Hintermann, Edith, Matthias von G. Herrath, Josef Pfeilschifter, Rhode, Antje, Bayer, Monika, Manns, Michael P., Antje Rhode   +23 more
core   +1 more source

CVID-associated TACI mutations affect autoreactive B cell selection and activation [PDF]

, 2013
Common variable immune deficiency (CVID) is an assorted group of primary diseases that clinically manifest with antibody deficiency, infection susceptibility, and autoimmunity.
Tuure Kinnunen, Gentile, M, Cantaert, T, Tineke Cantaert, Menard, L, Laurence Menard, Morbach, H, Saadoun, D, Virdee, M, Neil Romberg, Kinnunen, T, Maurizio Gentile, Rachid, R, Martinez-Pomar, N, Geha, R, Henner Morbach, Matamoros, N, Cunningham-Rundles, C, Nicolas Chamberlain, Nuria Matamoros, Andrea Cerutti, Yen Shing Ng, Bodo Grimbacher, Natalia Martinez-Pomar, Meffre, E, Eric Meffre, David Saadoun, Manmeet Virdee, Rima Rachid, Cerutti, A, Raif Geha, Romberg, N, Brimbacher, B, Chamberlain, N, Charlotte Cunningham-Rundles, Ng, YS   +35 more
core   +1 more source

The Role of Viral Infections in the Onset of Autoimmune Diseases

Viruses, 2023
Autoimmune diseases (AIDs) are the consequence of a breach in immune tolerance, leading to the inability to sufficiently differentiate between self and non-self.
Bhargavi Sundaresan, Fatemeh Shirafkan, Kevin Ripperger, Kristin Rattay   +3 more
doaj   +1 more source

Central Tolerance Regions and Reference Regions for Some Normal Populations [PDF]

, 2011
A reference interval represents a range of values that a physician can use in order to interpret a single test result from a patient. A 95% reference interval is simply the interval from the 2.5th to the 97.5th percentiles of the distribution of the test
Dong, Xiaoyu
core   +3 more sources