Results 41 to 50 of about 6,990,145 (285)
Normothermic central hypovolemia tolerance reflects hyperthermic tolerance [PDF]
Clinical Autonomic Research, 2014 To test the hypothesis that those who are highly tolerant to lower body negative pressure (LBNP) while normothermic are also highly tolerant to this challenge while hyperthermic.Sixty pairs of normothermic and hyperthermic LBNP tests to pre-syncope were evaluated.
Zachary J, Schlader, Craig G, Crandall
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The Multifaceted Roles of B Cells in the Thymus: From Immune Tolerance to Autoimmunity
Frontiers in Immunology, 2021 The thymus is home to a significant number of resident B cells which possess several unique characteristics regarding their origin, phenotype and function.
Justine Castañeda +7 more
doaj +1 more source
T-Cell Tolerance: Central and Peripheral [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 Somatic recombination of TCR genes in immature thymocytes results in some cells with useful TCR specificities, but also many with useless or potentially self-reactive specificities. Thus thymic selection mechanisms operate to shape the T-cell repertoire. Thymocytes that have a TCR with low affinity for self-peptide-MHC complexes are positively selected
Yan, Xing, Kristin A, Hogquist
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A role for phagocytosis in inducing cell death during thymocyte negative selection
eLife, 2019 Autoreactive thymocytes are eliminated during negative selection in the thymus, a process important for establishing self-tolerance. Thymic phagocytes serve to remove dead thymocytes, but whether they play additional roles during negative selection ...
Nadia S Kurd +6 more
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Frontiers in Immunology, 2021 CD4+CD25+Foxp3+T cell population is heterogenous and contains three major sub-groups. First, thymus derived T regulatory cells (tTreg) that are naïve/resting. Second, activated/memory Treg that are produced by activation of tTreg by antigen and cytokines.
Bruce M. Hall +17 more
doaj +1 more source
Control of central and peripheral tolerance by Aire [PDF]
Immunological Reviews, 2011 Summary: The negative selection of self‐reactive thymocytes depends on the expression of tissue‐specific antigens by medullary thymic epithelial cells. The autoimmune regulator (Aire) protein plays an important role in turning on these antigens, and the absence of even one Aire‐induced tissue‐specific antigen in the thymus can lead to autoimmunity in ...
Todd C, Metzger, Mark S, Anderson
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Tolerance of Muslim beliefs and practices: Age related differences and context effects [PDF]
, 2007 Tolerant judgments of Muslims’ political rights and dissenting beliefs and practices by ethnic Dutch adolescents (12–18 years) were examined. Participants (N = 632) made judgments of different types of behaviors and different contexts in an experimental ...
Slooter, Luuk +3 more
core +2 more sources
BiologyBackground: Rheumatoid arthritis (RA) is chronically persistent synovitis and systemic inflammation. Although multiple contributors are detected, only one is pivotal in the neonatal period: the negative selection of autoimmune naïve T-cells by the ...
Bálint Bérczi +6 more
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MOLECULAR AND CELLULAR MECHANISMS MEDIATED BY DENDRITIC CELLS INVOLVED IN THE INDUCTION OF TOLERANCE
Медицинская иммунология, 2017 Autoimmune diseases and complications after transplantation operations are major public health problem, as they often lead to deterioration in the quality of life, reduce work capacity and disability in the population.
S. V. Sennikov +3 more
doaj +1 more source
Frontiers in Immunology, 2020 The development of autoimmune disorders is incompletely understood. Inefficient thymic T cell selection against self-peptides presented by major histocompatibility antigens (HLA in humans) may contribute to the emergence of auto-reactive effector cells ...
Bernhard Loll +4 more
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