Results 61 to 70 of about 1,365,539 (250)

Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness. [PDF]

, 2017
Zap70 plays a critical role in normal T cell development and T cell function. However, little is known about how perturbation of allosteric autoinhibitory mechanisms in Zap70 impacts T cell biology.
Chen, Yiling, Cheng, Debra A, Hsu, Lih-Yun, Liang, Hong-Erh, Weiss, Arthur   +4 more
core   +2 more sources

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Silicon Sensors for Trackers at High-Luminosity Environment

, 2014
The planned upgrade of the LHC accelerator at CERN, namely the high luminosity (HL) phase of the LHC (HL-LHC foreseen for 2023), will result in a more intense radiation environment than the present tracking system was designed for.
Peltola, Timo
core   +1 more source

Lianas Suppress Seedling Growth and Survival of 14 Tree Species in a Panamanian Tropical Forest [PDF]

, 2016
Lianas are a common plant growth form in tropical forests, where they compete intensely with trees, decreasing tree recruitment, growth, and survival. If the detrimental effects of lianas vary significantly with tree species identity, as is often assumed,
Andrade, Beer, Bonan, Cahill, Cai, Carsten, Cavelier, Celis, Chen, Chen, Chittibabu, Clark, Clark, Cordero, Croat, Gibbs, Heijden, Heijden, Heijden, Hooper, IBM SPSS, Ingwell, Jennifer S. Powers, Kainer, Kira, Kitajima, Kitajima, Kurzel, Laura Martínez-Izquierdo, Laurance, Leigh, Lewis, María M. García, Nichols, Pan, Peña-Claros, Phillips, Poorter, Putz, Pérez-Salicrup, Pérez-Salicrup, Schnitzer, Schnitzer, Schnitzer, Schnitzer, Schnitzer, Schnitzer, Schnitzer, Schnitzer, Schnitzer, Schnitzer, Stefan A. Schnitzer, Stevens, Tanner, Tobin, Toledo-Aceves, Toledo-Aceves, Vleut, Windsor, Wright, Wright, Wright, Wyka, Yavitt, Zahawi, Álvarez-Cansino   +65 more
core   +2 more sources

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

The role of the L-arginine-NO-cGMP pathway in the development of tolerance to mephedrone-induced hyperlocomotion in mice

Current Issues in Pharmacy and Medical Sciences, 2023
The tendency of a psychostimulant to increase locomotion in rodents is considered to be associated with its addictive properties. Mephedrone, one of the most popular psychoactive substances used recreationally, is known to enhance locomotor activity in ...
Bielecka-Papierz Gabriela, Poleszak Ewa, Szopa Aleksandra, Listos Joanna, Orzelska-Gorka Jolanta, Jakobczuk Małgorzata, Baluk Kamila, Talarek Sylwia, Serefko Anna   +8 more
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

On central max-point-tolerance graphs

AKCE International Journal of Graphs and Combinatorics, 2020
Max-point-tolerance graphs (MPTG) were studied by Catanzaro et al. in 2017 and the same class of graphs were introduced in the name of p-BOX(1) graphs by Soto and Caro in 2015.
Sanchita Paul
doaj   +1 more source

Infection Control Practices for Vascular Access Management in Hemodialysis: Results From a Nationwide Survey of Japanese National University Hospitals

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Bloodstream infections due to repeated vascular access (VA) puncture and circuit connections remain major concerns in hemodialysis. Therefore, we examined current practices for glove, disinfectant, and personal protective equipment (PPE) use according to VA type in national university hospitals in Japan.
Aiko Yamada, Makoto Harada, Tadahiko Kikugawa, Takeshi Nakata, Koji Hashimoto, Tsuneo Konta, Yuji Kamijo   +6 more
wiley   +1 more source

Long-term outcome of bone marrow transplantation in NIK deficiency: non-redundant role of non-canonical NF-κB signaling in thymic reconstitution and secondary lymphoid organ development

Frontiers in Immunology
IntroductionBiallelic mutations in MAP3K14, encoding NF-κB-inducing kinase (NIK), disrupt non-canonical NF-κB signaling and lead to a rare inborn error of immunity marked by impaired lymphoid organ development, defective lymphocyte maturation, and ...
Sevgi Köstel Bal, Sevgi Köstel Bal, Şule Haskoloğlu, Bernhard Ransmayr, Bernhard Ransmayr, Selin Sevinç, Candan İslamoğlu, Kübra Baskın, Nazlı Deveci, Berna Savaş, Suat Fitoz, Alphan Küpesiz, Tanıl Kendirli, Kaan Boztug, Kaan Boztug, Kaan Boztug, Figen Doğu, Kamile Aydan İkincioğulları   +17 more
doaj   +1 more source