Results 71 to 80 of about 473,837 (287)

The role of fatty acid metabolism in drug tolerance of mycobacterium tuberculosis [PDF]

, 2022
Mycobacterium tuberculosis can cocatabolize a range of carbon sources.Fatty acids are among the carbons available inside the host’s macrophages. Here, we investigated the metabolic changes of the fatty acid-induced dormancy-like state of M.
Lawson, C.P., Quinonez, Camila G., Anyogu, A., Odell, Mark, Lee, Jae Jin, Gaspar Quinonez, C., Lim, J., Raheem, S., Raheem, Saki, Anyogu, Amararachukwu, Anyogu, Amarachukwu, Lawson, Christopher P., Lim, Juhyeon, Eoh, Hyungjin, Eoh, H., Lee, J.J., Odell, M.   +16 more
core   +1 more source

The RANKL-RANK Axis: A Bone to Thymus Round Trip

Frontiers in Immunology, 2019
The identification of Receptor activator of nuclear factor kappa B ligand (RANKL) and its cognate receptor Receptor activator of nuclear factor kappa B (RANK) during a search for novel tumor necrosis factor receptor (TNFR) superfamily members has ...
Cristina Sobacchi, Cristina Sobacchi, Ciro Menale, Ciro Menale, Anna Villa, Anna Villa   +5 more
doaj   +1 more source

Central tolerance and autoimmune diseases

Japanese Journal of Clinical Immunology, 2006
Central tolerance is established by the repertoire selection of immature T lymphocytes in the thymus, avoiding autoimmune responses to self-antigens. Differential ligand-TCR interactions that result in positive and negative selection initiate differential intracellular signals that, in turn, lead to the survival-or-death decision of immature thymocytes.
NITTA, Takeshi, TAKAHAMA, Yousuke
openaire   +3 more sources

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Mechanisms of immunological tolerance in central nervous system inflammatory demyelination. [PDF]

, 2015
Multiple sclerosis is a complex autoimmune disease of the central nervous system that results in a disruption of the balance between pro-inflammatory and anti-inflammatory signals in the immune system.
Rostami, A. M., Guang‐Xian Zhang, Abdolmohamad Rostami, Zhang, Guang-Xian, Moore, Jason N., Elisabeth R. Mari, Jason N. Moore, Mari, Elisabeth R.   +7 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning [PDF]

, 2008
Allogeneic hematopoietic chimerism leading to central tolerance has significant therapeutic potential. Realization of that potential has been impeded by the need for myeloablative conditioning of the host and development of graft-versus-host disease ...
Mordes, John P., Seung, Edward, Rossini, Aldo A., Greiner, Dale L.   +3 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs [PDF]

, 2012
The correction of hypovolemia with acellular fluids results in acute normovolemic anemia. Whether the choice of the infusion fluid has an impact on the maintenance of oxygen (O2) supply during acute normovolemic anemia has not been investigated so far ...
Oliver Horn, Bernhard Zwissler, Stein, Peter, Peter Stein, Horn, Oliver, Zwißler, Bernhard, Andreas Pape, Oliver Habler, Pape, Andreas, Lossen, Mischa, Mischa Lossen, Habler, Oliver, Saskia Kutschker, Kutschker, Saskia, Kertscho, Harry, Harry Kertscho   +15 more
core   +1 more source

On the Role of Peripheral Sensory and Gut Mu Opioid Receptors: Peripheral Analgesia and Tolerance

Molecules, 2020
There is growing evidence on the role of peripheral µ-opioid receptors (MORs) in analgesia and analgesic tolerance. Opioid analgesics are the mainstay in the management of moderate to severe pain, and their efficacy in the alleviation of pain is well ...
Susanna Fürst, Zoltán S. Zádori, Ferenc Zádor, Kornél Király, Mihály Balogh, Szilvia B. László, Barbara Hutka, Amir Mohammadzadeh, Chiara Calabrese, Anna Rita Galambos, Pál Riba, Patrizia Romualdi, Sándor Benyhe, Júlia Timár, Helmut Schmidhammer, Mariana Spetea, Mahmoud Al-Khrasani   +16 more
doaj   +1 more source