Results 81 to 90 of about 473,837 (287)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Acid tolerance and organic acid susceptibility of selected food-borne pathogens [PDF]
, 2013 Published ArticleThe development of tolerance to low pH levels and the existence of cross-resistance may promote survival of bacteria in acidic foodstuff and in acidic environments such as the human stomach, in so doing escalating the probability of food
Slabbert, R.S
core
Breaking through the central tolerance ceiling to unleash anticancer immune responses [PDF]
, 2014 Central thymic tolerance mechanisms create a formidable barrier against the generation of self-reactive T cells. While preventing autoimmunity, this barrier also limits an effective antitumor immunological response.
Su, Maureen A, Anderson, Mark S
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Religious Tolerance Tourism and Jahan Experience [PDF]
, 2022 The article discusses the religious tourism, the history of religious tourism in the European example, forms of religious tourism, religious tolerance tourism and differences between religious and religious tolerance ...
Azamovich, Mirzayev Axrorjon
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Frontiers in ImmunologyIntroductionBiallelic mutations in MAP3K14, encoding NF-κB-inducing kinase (NIK), disrupt non-canonical NF-κB signaling and lead to a rare inborn error of immunity marked by impaired lymphoid organ development, defective lymphocyte maturation, and ...
Sevgi Köstel Bal +17 more
doaj +1 more source
Current Issues in Pharmacy and Medical Sciences, 2023 The tendency of a psychostimulant to increase locomotion in rodents is considered to be associated with its addictive properties. Mephedrone, one of the most popular psychoactive substances used recreationally, is known to enhance locomotor activity in ...
Bielecka-Papierz Gabriela +8 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Emerging roles of microRNAs in morphine tolerance [PDF]
, 2019 Jiangju Huang, Jian Wang, Qulian Guo, Wangyuan ZouDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of ChinaAbstract: Morphine is commonly used in clinical management to alleviate ...
Huang J, Wang J, Guo Q, Zou W
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Frontiers in Immunology, 2017 Immunization with myelin components can elicit experimental autoimmune encephalomyelitis (EAE). EAE susceptibility varies between mouse strains, depending on the antigen employed. BL/6 mice are largely resistant to EAE induction with proteolipid protein (
Lei Wang +8 more
doaj +1 more source