Results 91 to 100 of about 473,837 (287)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Gold uptake and tolerance in Arabidopsis [PDF]
, 2011 Gold is a precious metal with a variety of industrial uses. The gold mining process is often incomplete, and discarded mine tailings contain quantities of gold uneconomical for conventional extraction.
Taylor, Andrew
core
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Exploring antigenic variation in autoimmune endocrinopathy
Frontiers in ImmunologyAutoimmune disorders develop owing to a misdirected immune response against self-antigen. Genetic studies have revealed that numerous variants in genes encoding immune system proteins are associated with the development of autoimmunity.
Maria Mavridou +2 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Breakdown of thymic tolerance - an etiologic link between acute and chronic graft-versus-host disease [PDF]
, 2014 Allogeneic haematopoietic stem cell transplantation (HSCT) is the standard therapy for many disorders of the haematological system. Its use is limited by the major complication acute graft-versus-host disease (GVHD). Development of acute GVHD predisposes
Dertschnig, Simone
core +1 more source
Senolytic Vaccines from the Central and Peripheral Tolerance Perspective
VaccinesPreventive medicine has proven its long-term effectiveness and economic feasibility. Over the last century, vaccination has saved more lives than any other medical technology.
Mariia I. Vasilieva +6 more
doaj +1 more source
The occurrence of tolerance to a central depressant effect of nicotine [PDF]
British Journal of Pharmacology, 1972 Summary . Rats were injected with 0·8 mg nicotine/kg, 0·8 mg amphetamine/kg or with saline immediately before being tested for 30 min in activity boxes. . During the first 3 trials the nicotine group were less active than the controls but from trial 5 onwards nicotine had a stimulant effect.
C F, Morrison, J A, Stephenson
openaire +2 more sources
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Access to health care for Roma children in Central and Eastern Europe: findings from a qualitative study in Bulgaria [PDF]
, 2009 Background: Despite the attention the situation of the Roma in Central and Eastern Europe has received in the context of European Union enlargement, research on their access to health services is very limited, in particular with regard to child health ...
Blackburn, Clare +11 more
core +1 more source