Results 111 to 120 of about 447,256 (145)

Central Tolerance Induction

2013
A critical function of the thymus is to help enforce tolerance to self. The importance of central tolerance in preventing autoimmunity has been enlightened by a deeper understanding of the interactions of developing T cells with a diverse population of thymic antigen presenting cell populations.
Maria L, Mouchess, Mark, Anderson
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The Thymus and Central Tolerance

Hormone and Metabolic Research, 1996
Thymic selection programs T lymphocytes to tolerate self antigens but respond to foreign antigens. The mechanisms involved in self tolerance induction are discussed.
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Chimerism and central tolerance

Current Opinion in Immunology, 1996
With adequate depletion or inactivation of the pre-existing immune system and establishment of conditions permitting donor hematopoietic stem cell engraftment, a robust state of central deletional tolerance to allogeneic or xenogeneic donors can be induced.
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Tolerance to centrally administered phenobarbital

Biochemical Pharmacology, 1976
Abstract Rats with permanent indwelling cerebral ventricular cannulae were shown to lose their righting reflex in response to centrally injected phenobarbital in a dose-related manner. Administration of four daily injections of 800 μg each over a 4- to 5-day period produced a gradual tolerance to the hypnotic effect, which was reversible after ...
M J, Mycek, H E, Brezenoff
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Central tolerance: good but imperfect

Immunological Reviews, 2006
Summary:  T‐cell development is a highly coordinated process that depends on interactions between thymocytes, thymic epithelium, and bone marrow (BM)‐derived dendritic cells (DCs). Before entering the peripheral T‐cell pool, thymocytes are subject to negative selection, a process that eliminates (or deletes) T cells with high affinity toward self ...
Alena M, Gallegos, Michael J, Bevan
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Cross-tolerance to centrally injected barbiturates

European Journal of Pharmacology, 1979
Hypnotic responses to intracerebroventricular (i.c.v) injections of either barbital, pentobarbital, R(-) and S(+) mephorbarbital, or racemic metharbital were compared to those produced by phenobarbital. Dose--response relationships were obtained for all except S(+) mephorbarbital and metharbital. Chronic i.c.v.
W H, Lyness, H E, Brezenoff, M J, Mycek
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A defect in central tolerance in NOD mice

Nature Immunology, 2001
The predisposition of nonobese diabetic (NOD) mice to develop autoimmune disease is usually attributed to defects in peripheral tolerance mechanisms. Here, evidence is presented that NOD mice display a defect in central tolerance (negative selection) of thymocytes. Impaired central tolerance in NOD mice was most prominent in a population of semi-mature
H, Kishimoto, J, Sprent
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Medullary interplay for central tolerance

Blood, 2011
To establish central tolerance in T cells, Aire, a nuclear protein expressed in medullary thymic epithelial cells, not only induces the ectopic expression of various self-antigens but also facilitates the indirect presentation of medullary thymic epithelial cell (mTEC)–derived self-antigens ...
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Tissue Tolerance: Central Nervous System

Radiology, 1968
IN 1958 LAMPE (13) surveyed the experience to date with radiation tolerance of the central nervous system. He concluded that, as of that time, precise radiation tolerance limits of the central nervous system were not known for clinical radio-therapeutic practice. This still holds true today.
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Tolerance and cross-tolerance to mescaline and amphetamine as a function of central and peripheral administration

Psychopharmacologia, 1972
Differences in tolerance and cross-tolerance to the behavioral effects of d-amphetamine sulfate and mescaline hydrochloride were studied as a function of intraventricular or intraperitoneal routes of administration. Operant behavior, using a fixed ratio schedule of food reinforcement, was the behavioral variable.
S B, Sparber, H A, Tilson
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