Results 101 to 110 of about 447,256 (145)

The Prerequisites for Central Tolerance Induction against Citrullinated Proteins in the Mouse. [PDF]

PLoS One, 2016
Engelmann R, Biemelt A, Cordshagen A, Johl A, Kuthning D, Müller-Hilke B.   +5 more
europepmc   +1 more source

How does the immune system learn to distinguish between good and evil? The first definitive studies of T cell central tolerance and positive selection. [PDF]

Immunogenetics, 2019
Kisielow P.
europepmc   +1 more source

Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance. [PDF]

Cell Rep, 2016
Perera J, Zheng Z, Li S, Gudjonson H, Kalinina O, Benichou JIC, Block KE, Louzoun Y, Yin D, Chong AS, Dinner AR, Weigert M, Huang H.   +12 more
europepmc   +1 more source

Permissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis

Sun B, Fernandes D, Kienzler A, Paneva S, Harrison R, Ramanathan S, Harrison AL, Makuch M, Fichtner ML, Donat RF, Akdeniz D, Bayuangga H, Im MG, Williams R, Vasconcelos A, Thomsen S, Fower A, Sun R, Fox H, Mgbachi V, Davies A, Tseng M, Handel A, Kelly M, Zhao M, Bancroft J, Bashford-Rogers R, Pluvinage JV, Dandekar R, Alvarenga BD, Dustin L, Rinaldi S, Owens R, Anthony D, Bennett DL, Waters P, Davis SJ, Wilson MR, O’Connor KC, Soltys J, Carvalho AL, Irani SR.   +41 more
europepmc   +1 more source

The Thymic Orchestration Involving Aire, miRNAs, and Cell-Cell Interactions during the Induction of Central Tolerance. [PDF]

Front Immunol, 2015
Passos GA, Mendes-da-Cruz DA, Oliveira EH.   +2 more
europepmc   +1 more source

Thymus-homing dendritic cells in central tolerance. [PDF]

Eur J Immunol, 2013
Hadeiba H, Butcher EC.
europepmc   +1 more source

Correction: The role of B cells in the pathogenesis of type 1 diabetes. [PDF]

Front Immunol
Wang YN, Li R, Huang Y, Chen H, Nie H, Liu L, Zou X, Zhong J, Zheng B, Gong Q.   +9 more
europepmc   +1 more source

Editorial for the Special Issue "Metabolic Analysis of Plant Development and Defense Responses". [PDF]

Plants (Basel)
Amin A.
europepmc   +1 more source

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Central Tolerance of T Cells

International Reviews of Immunology, 1995
The immune system is constructed to tolerate self antigens but give vigorous responses to foreign antigens. How this state of self/nonself discrimination is maintained is controversial. In the case of T cells, many self antigens are transported to the thymus via the bloodstream and induce tolerance (clonal deletion) of self-reactive thymocytes in situ.
exaly   +3 more sources

A CENTRAL ROLE FOR CENTRAL TOLERANCE

Annual Review of Immunology, 2006
Recent elucidation of the role of central tolerance in preventing organ-specific autoimmunity has changed our concepts of self/nonself discrimination. This paradigmatic shift is largely attributable to the discovery of promiscuous expression of tissue-restricted self-antigens (TRAs) by medullary thymic epithelial cells (mTECs).
Bruno, Kyewski, Ludger, Klein
openaire   +2 more sources