Results 101 to 110 of about 473,837 (287)

Transcriptomic profiling of thymic dysregulation and viral tropism after neonatal roseolovirus infection

Frontiers in Immunology
IntroductionHerpesviruses, including the roseoloviruses, have been linked to autoimmune disease. The ubiquitous and chronic nature of these infections have made it difficult to establish a causal relationship between acute infection and subsequent ...
Andrei Belean, Eden Xue, Benjamin Cisneros, Elisha D. O. Roberson, Elisha D. O. Roberson, Elisha D. O. Roberson, Michael A. Paley, Michael A. Paley, Tarin M. Bigley, Tarin M. Bigley, Tarin M. Bigley   +10 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Transposable elements regulate thymus development and function

eLife
Transposable elements (TEs) are repetitive sequences representing ~45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTECs).
Jean-David Larouche, Céline M Laumont, Assya Trofimov, Krystel Vincent, Leslie Hesnard, Sylvie Brochu, Caroline Côté, Juliette F Humeau, Éric Bonneil, Joel Lanoix, Chantal Durette, Patrick Gendron, Jean-Philippe Laverdure, Ellen R Richie, Sébastien Lemieux, Pierre Thibault, Claude Perreault   +16 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The comparative ecology of Minuartia verna (L.) Hiern and Thlaspi alpestre L. in the southern pennines, with special reference to heavy metal tolerance. [PDF]

, 1987
Minuartia verna (L.) Hiern and Thiaspi alpestre L. are recognized as relict elements of a preglacial montane flora in the British Isles and, as such, display a markedly disjunct distribution pattern.
Hajar, Abdulrahman Said Muhammad
core  

TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance [PDF]

, 2023
Central B cell tolerance is believed to be regulated by B cell receptor signaling induced by the recognition of self-antigens in immature B cells. Using humanized mice with defective MyD88, TLR7, or TLR9 expression, we demonstrate that TLR9/MYD88 are ...
Meffre, Eric, Hoischen, Alexander, Schickel, Jean Nicolas, Hayward, Anthony, Oliver, David, Moody, Krishna L., Kioon, Marie Dominique Ah, van der Made, Caspar I., Herzog, Erica L., Garcia-Carmona, Yolanda, Cunningham-Rundles, Charlotte, Yang, Chao, Nündel, Kerstin, Çakan, Elif, Yamakawa, Natsuko, Staudt, Louis M., Loza, Andrea Vega, Du, Yong, Boeckers, Joshua M., Barrat, Franck J., Rossato, Marzia, Glauzy, Salomé, Baldo, Alessia, Ivashkiv, Lionel B., Ryu, Changwan, Marshak-Rothstein, Ann, Young, Ryan M., Radstake, Timothy R.D.J.   +27 more
core  

Systemic TLR2 tolerance enhances central nervous system remyelination

Journal of Neuroinflammation, 2019
Background Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by both inflammatory demyelination and impaired remyelination.
Nicholas J. Wasko, Meghan Horne Kulak, Debayon Paul, Alexandra M. Nicaise, Stephen T. Yeung, Frank C. Nichols, Kamal M. Khanna, Stephen Crocker, Joel S. Pachter, Robert B. Clark   +9 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source