Results 51 to 60 of about 1,365,539 (250)
Clinical Insights Into Hypercalcemia of Malignancy in Childhood
Pediatric Blood &Cancer, EarlyView.ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley +1 more source
MOLECULAR AND CELLULAR MECHANISMS MEDIATED BY DENDRITIC CELLS INVOLVED IN THE INDUCTION OF TOLERANCE
Медицинская иммунология, 2017 Autoimmune diseases and complications after transplantation operations are major public health problem, as they often lead to deterioration in the quality of life, reduce work capacity and disability in the population.
S. V. Sennikov +3 more
doaj +1 more source
Murine liver allograft transplantation: Tolerance and donor cell chimerism [PDF]
, 1994 Nonarterialized orthotopic liver transplantation with no immunosuppression was performed in 13 mouse‐strain combinations. Two strain combinations with major histocompatibility complex class I and class II and minor histocompatibility complex disparity ...
Arnold +45 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács +8 more
wiley +1 more source
II. THE SYSTEM OF AUTOTOLERANCE AND ITS FUNCTIONING IN ALLOGENIC ORGAN TRANSPLANTATION
Вестник трансплантологии и искусственных органов, 2010 It was ascertained, that induction of transplantation tolerance are bound with the using of regulatory possibilities of donor’s bone marrow cells.
S. D. Artamonov +6 more
doaj +1 more source
Zero tolerance policing: new authoritarianism or new liberalism? [PDF]
, 2002 The notion of “zero tolerance” policing has been widely discussed in the media in recent years and has received considerable support from politicians right across the political spectrum both in the USA and the UK. Proponents of this apparently “get-tough”
Hopkins Burke, RD
core
The RANKL-RANK Axis: A Bone to Thymus Round Trip
Frontiers in Immunology, 2019 The identification of Receptor activator of nuclear factor kappa B ligand (RANKL) and its cognate receptor Receptor activator of nuclear factor kappa B (RANK) during a search for novel tumor necrosis factor receptor (TNFR) superfamily members has ...
Cristina Sobacchi +5 more
doaj +1 more source
Breach of tolerance: primary biliary cirrhosis. [PDF]
, 2014 In primary biliary cirrhosis (PBC), the breach of tolerance that leads to active disease involves a disruption in several layers of control, including central tolerance, peripheral anergy, a liver tolerance effect, and the action of T regulatory cells ...
Chang, Christopher +3 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson +3 more
wiley +1 more source
On the Role of Peripheral Sensory and Gut Mu Opioid Receptors: Peripheral Analgesia and Tolerance
Molecules, 2020 There is growing evidence on the role of peripheral µ-opioid receptors (MORs) in analgesia and analgesic tolerance. Opioid analgesics are the mainstay in the management of moderate to severe pain, and their efficacy in the alleviation of pain is well ...
Susanna Fürst +16 more
doaj +1 more source