Results 51 to 60 of about 473,837 (287)

The Multifaceted Roles of B Cells in the Thymus: From Immune Tolerance to Autoimmunity

Frontiers in Immunology, 2021
The thymus is home to a significant number of resident B cells which possess several unique characteristics regarding their origin, phenotype and function.
Justine Castañeda, Yessia Hidalgo, Daniela Sauma, Mario Rosemblatt, Mario Rosemblatt, Mario Rosemblatt, María Rosa Bono, Sarah Núñez   +7 more
doaj   +1 more source

Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion [PDF]

, 2008
B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity.
Müller, Werner, Frommer, Friederike, Heinen, Tobias J. A. J., Buch, Thorsten, Heinen, Tobias J A J, Anderton, Stephen M, Bettelli, Estelle, Waisman, Ari, Wunderlich, F Thomas, Mueller, Werner, Wunderlich, F. Thomas, Roers, Axel, Müller, Werner; id_orcid, Yogev, Nir, Anderton, Stephen M.   +14 more
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Interleukin-5 (IL-5) Therapy Prevents Allograft Rejection by Promoting CD4+CD25+ Ts2 Regulatory Cells That Are Antigen-Specific and Express IL-5 Receptor

Frontiers in Immunology, 2021
CD4+CD25+Foxp3+T cell population is heterogenous and contains three major sub-groups. First, thymus derived T regulatory cells (tTreg) that are naïve/resting. Second, activated/memory Treg that are produced by activation of tTreg by antigen and cytokines.
Bruce M. Hall, Bruce M. Hall, Rachael M. Hall, Rachael M. Hall, Giang T. Tran, Giang T. Tran, Catherine M. Robinson, Catherine M. Robinson, Paul L. Wilcox, Paul L. Wilcox, Prateek K. Rakesh, Prateek K. Rakesh, Chuanmin Wang, Alexandra F. Sharland, Nirupama D. Verma, Nirupama D. Verma, Suzanne J. Hodgkinson, Suzanne J. Hodgkinson   +17 more
doaj   +1 more source

Breeding drought tolerant cowpea: constraints, accomplishments, and future prospects [PDF]

, 2009
This review presents an overview of accomplishments on different aspects of cowpea breeding for drought tolerance. Furthermore it provides options to enhance the genetic potential of the crop by minimizing yield loss due to drought stress. Recent efforts
Visser, R.G.F., Muranaka, S., Agbicodo, A.C.M.E., Linden, C.G., van der, Fatokun, C.A.   +4 more
core   +1 more source

A role for phagocytosis in inducing cell death during thymocyte negative selection

eLife, 2019
Autoreactive thymocytes are eliminated during negative selection in the thymus, a process important for establishing self-tolerance. Thymic phagocytes serve to remove dead thymocytes, but whether they play additional roles during negative selection ...
Nadia S Kurd, Lydia K Lutes, Jaewon Yoon, Shiao Wei Chan, Ivan L Dzhagalov, Ashley R Hoover, Ellen A Robey   +6 more
doaj   +1 more source

The SNF1-type serine-threonine protein kinase SAPK4 regulates stress-responsive gene expression in rice [PDF]

, 2008
Diedhiou CJ, Popova OV, Dietz K-J, Golldack D. The SNF1-type serine-threonine protein kinase SAPK4 regulates stress-responsive gene expression in rice. BMC PLANT BIOLOGY.
Popova Olga V, Dietz, Karl-Josef, Diédhiou Calliste J, Golldack Dortje, Golldack, Dortje, Dietz Karl-Josef, Diedhiou, Calliste J., Popova, Olga V.   +7 more
core   +2 more sources

Control of central and peripheral tolerance by Aire [PDF]

Immunological Reviews, 2011
Summary:  The negative selection of self‐reactive thymocytes depends on the expression of tissue‐specific antigens by medullary thymic epithelial cells. The autoimmune regulator (Aire) protein plays an important role in turning on these antigens, and the absence of even one Aire‐induced tissue‐specific antigen in the thymus can lead to autoimmunity in ...
Todd C, Metzger, Mark S, Anderson
openaire   +2 more sources

T-Cell Tolerance: Central and Peripheral [PDF]

Cold Spring Harbor Perspectives in Biology, 2012
Somatic recombination of TCR genes in immature thymocytes results in some cells with useful TCR specificities, but also many with useless or potentially self-reactive specificities. Thus thymic selection mechanisms operate to shape the T-cell repertoire. Thymocytes that have a TCR with low affinity for self-peptide-MHC complexes are positively selected
Yan, Xing, Kristin A, Hogquist
openaire   +2 more sources

Guidelines for Pediatric Radiotherapy Simulation: A Report From the Children's Oncology Group Radiation Oncology Discipline

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei, Stephen Mihalcik, Sujith Baliga, Young Kwok, Dana Casey, Eric Ehler, Christiane Burton, John C. Breneman, Daphne A. Haas‐Kogan, Suzanne L. Wolden, Arnold C. Paulino, Nadia N. Laack, Natia Esiashvili, Sarah Milgrom, Christine Hill‐Kayser, Thomas J. Fitzgerald, John A. Kalapurakal, Chia‐Ho Hua   +17 more
wiley   +1 more source

Zero tolerance policing: new authoritarianism or new liberalism? [PDF]

, 2002
The notion of “zero tolerance” policing has been widely discussed in the media in recent years and has received considerable support from politicians right across the political spectrum both in the USA and the UK. Proponents of this apparently “get-tough”
Hopkins Burke, RD
core