Results 31 to 40 of about 6,990,145 (285)

Thymic Epithelial Cell Alterations and Defective Thymopoiesis Lead to Central and Peripheral Tolerance Perturbation in MHCII Deficiency

Frontiers in Immunology, 2021
Major Histocompatibility Complex (MHC) class II (MHCII) deficiency (MHCII-D), also known as Bare Lymphocyte Syndrome (BLS), is a rare combined immunodeficiency due to mutations in genes regulating expression of MHCII molecules.
Francesca Ferrua, Francesca Ferrua, Francesca Ferrua, Ileana Bortolomai, Elena Fontana, Elena Fontana, Dario Di Silvestre, Rosita Rigoni, Rosita Rigoni, Genni Enza Marcovecchio, Elena Draghici, Francesca Brambilla, Maria Carmina Castiello, Maria Carmina Castiello, Gloria Delfanti, Despina Moshous, Despina Moshous, Capucine Picard, Capucine Picard, Capucine Picard, Tom Taghon, Victoria Bordon, Ansgar S. Schulz, Catharina Schuetz, Catharina Schuetz, Silvia Giliani, Annarosa Soresina, Andrew R. Gennery, Andrew R. Gennery, Sara Signa, Sara Signa, Blachy J. Dávila Saldaña, Ottavia M. Delmonte, Luigi D. Notarangelo, Chaim M. Roifman, Pietro Luigi Poliani, Paolo Uva, Pier Luigi Mauri, Anna Villa, Anna Villa, Marita Bosticardo, Marita Bosticardo   +41 more
doaj   +1 more source

Alloactivation of Naïve CD4+CD8−CD25+T Regulatory Cells: Expression of CD8α Identifies Potent Suppressor Cells That Can Promote Transplant Tolerance Induction

Frontiers in Immunology, 2019
Therapy with alloantigen-specific CD4+CD25+ T regulatory cells (Treg) for induction of transplant tolerance is desirable, as naïve thymic Treg (tTreg) are not alloantigen-specific and are weak suppressor cells.
Nirupama D. Verma, Catherine M. Robinson, Nicole Carter, Paul Wilcox, Giang T. Tran, Chaunmin Wang, Alexandra Sharland, Masaru Nomura, Karren M. Plain, G. Alexander Bishop, Suzanne J. Hodgkinson, Bruce M. Hall   +11 more
doaj   +1 more source

MHC Class II Presentation in Autoimmunity

Cells, 2023
Antigen presentation by major histocompatibility complex class II (MHC-II) molecules is crucial for eliciting an efficient immune response by CD4+ T cells and maintaining self-antigen tolerance.
Irina A. Ishina, Maria Y. Zakharova, Inna N. Kurbatskaia, Azad E. Mamedov, Alexey A. Belogurov, Alexander G. Gabibov   +5 more
doaj   +1 more source

Activity Based Tolerance Allocation (ABTA) – Driving tolerance synthesis by evaluating its global cost [PDF]

, 2009
This paper deals with tolerance allocation driven by an activity based approach. Its main objective is to rationally give a good indicator of the relevance of tolerances values fixed by designers.
MARTIN, Patrick, SIADAT, Ali, DANTAN, Jean-Yves, ETIENNE, Alain   +3 more
core   +1 more source

CCR4 promotes medullary entry and thymocyte–dendritic cell interactions required for central tolerance [PDF]

Journal of Experimental Medicine, 2015
Lauren Ehrlich, Jessica Lancaster
exaly   +2 more sources

The Contribution of Chemokines and Migration to the Induction of Central Tolerance in the Thymus [PDF]

Frontiers in Immunology, 2015
Lauren Ehrlich
exaly   +2 more sources

Tolerance analysis approach based on the classification of uncertainty (aleatory / epistemic) [PDF]

, 2012
Uncertainty is ubiquitous in tolerance analysis problem. This paper deals with tolerance analysis formulation, more particularly, with the uncertainty which is necessary to take into account into the foundation of this formulation.
Qureshi, A.J., LEMAIRE, Maurice, Etienne, A., DANTAN, Jean-Yves, Gayton, Nicolas, QURESHI, Ahmed Jawad, GAYTON, N., Lemaire, M., ETIENNE, Alain, Dantan, J.Y.   +9 more
core   +1 more source

CCR7 Modulates the Generation of Thymic Regulatory T Cells by Altering the Composition of the Thymic Dendritic Cell Compartment

Cell Reports, 2017
Upon recognition of auto-antigens, thymocytes are negatively selected or diverted to a regulatory T cell (Treg) fate. CCR7 is required for negative selection of auto-reactive thymocytes in the thymic medulla.
Zicheng Hu, Yu Li, Annemarie Van Nieuwenhuijze, Hilary J. Selden, Angela M. Jarrett, Anna G. Sorace, Thomas E. Yankeelov, Adrian Liston, Lauren I.R. Ehrlich   +8 more
doaj   +1 more source

Is T Cell Negative Selection a Learning Algorithm?

Cells, 2020
Our immune system can destroy most cells in our body, an ability that needs to be tightly controlled. To prevent autoimmunity, the thymic medulla exposes developing T cells to normal “self” peptides and prevents any responders from entering ...
Inge M. N. Wortel, Can Keşmir, Rob J. de Boer, Judith N. Mandl, Johannes Textor   +4 more
doaj   +1 more source

The Role of Viral Infections in the Onset of Autoimmune Diseases

Viruses, 2023
Autoimmune diseases (AIDs) are the consequence of a breach in immune tolerance, leading to the inability to sufficiently differentiate between self and non-self.
Bhargavi Sundaresan, Fatemeh Shirafkan, Kevin Ripperger, Kristin Rattay   +3 more
doaj   +1 more source