Results 31 to 40 of about 473,837 (287)

Redefining thymus medulla specialization for central tolerance [PDF]

Journal of Experimental Medicine, 2017
Alexei V Tumanov, Andrea White, Kieran D James   +2 more
exaly   +2 more sources

Editing T cell repertoire by thymic epithelial cell-directed gene transfer abrogates risk of type 1 diabetes development

Molecular Therapy: Methods & Clinical Development, 2022
Insulin is the primary autoantigen (Ag) targeted by T cells in type 1 diabetes (T1D). Although biomarkers precisely identifying subjects at high risk of T1D are available, successful prophylaxis is still an unmet need.
Fabio Russo, Eliana Ruggiero, Rosalia Curto, Laura Passeri, Francesca Sanvito, Ileana Bortolomai, Anna Villa, Silvia Gregori, Andrea Annoni   +8 more
doaj   +1 more source

Thymic central tolerance takes centre stage in autoimmune disease [PDF]

The Lancet Regional Health. Western Pacific
Smaila Mulic-Al Bunni, Adam E. Handel
doaj   +2 more sources

Exploring the Origin and Antigenic Specificity of Maternal Regulatory T Cells in Pregnancy

Frontiers in Immunology, 2020
Successful pregnancy outcome is partially determined by the suppression of reactive effector T cells by maternal regulatory T cells (TRegs) at the maternal-fetal interface.
Soo Hyun Ahn, Sean L. Nguyen, Sean L. Nguyen, Margaret G. Petroff, Margaret G. Petroff, Margaret G. Petroff   +5 more
doaj   +1 more source

Mechanisms of Direct and Indirect Presentation of Self-Antigens in the Thymus

Frontiers in Immunology, 2022
The inevitability of evolution of the adaptive immune system with its mechanism of randomly rearranging segments of the T cell receptor (TCR) gene is the generation of self-reactive clones. For the sake of prevention of autoimmunity, these clones must be
Jiří Březina, Matouš Vobořil, Dominik Filipp   +2 more
doaj   +1 more source

Post-Aire Medullary Thymic Epithelial Cells and Hassall’s Corpuscles as Inducers of Tonic Pro-Inflammatory Microenvironment

Frontiers in Immunology, 2021
While there is convincing evidence on the role of Aire-positive medullary thymic epithelial cells (mTEC) in the induction of central tolerance, the nature and function of post-Aire mTECs and Hassall’s corpuscles have remained enigmatic. Here we summarize
Martti Laan, Ahto Salumets, Ahto Salumets, Annabel Klein, Kerli Reintamm, Rudolf Bichele, Hedi Peterson, Pärt Peterson   +7 more
doaj   +1 more source

The genomic basis of copper tolerance in Drosophila is shaped by a complex interplay of regulatory and environmental factors [PDF]

, 2022
BACKGROUND: Escalation in industrialization and anthropogenic activity have resulted in an increase of pollutants released into the environment. Of these pollutants, heavy metals such as copper are particularly concerning due to their bio-accumulative ...
Salces-Ortiz, Judit, Rech, Gabriel E., Green, Llewellyn, Coronado, Marta, González, Josefa, González Pérez, Josefa, Radío, Santiago, Coronado-Zamora, Marta   +7 more
core   +1 more source

Thymic Epithelial Cell Alterations and Defective Thymopoiesis Lead to Central and Peripheral Tolerance Perturbation in MHCII Deficiency

Frontiers in Immunology, 2021
Major Histocompatibility Complex (MHC) class II (MHCII) deficiency (MHCII-D), also known as Bare Lymphocyte Syndrome (BLS), is a rare combined immunodeficiency due to mutations in genes regulating expression of MHCII molecules.
Francesca Ferrua, Francesca Ferrua, Francesca Ferrua, Ileana Bortolomai, Elena Fontana, Elena Fontana, Dario Di Silvestre, Rosita Rigoni, Rosita Rigoni, Genni Enza Marcovecchio, Elena Draghici, Francesca Brambilla, Maria Carmina Castiello, Maria Carmina Castiello, Gloria Delfanti, Despina Moshous, Despina Moshous, Capucine Picard, Capucine Picard, Capucine Picard, Tom Taghon, Victoria Bordon, Ansgar S. Schulz, Catharina Schuetz, Catharina Schuetz, Silvia Giliani, Annarosa Soresina, Andrew R. Gennery, Andrew R. Gennery, Sara Signa, Sara Signa, Blachy J. Dávila Saldaña, Ottavia M. Delmonte, Luigi D. Notarangelo, Chaim M. Roifman, Pietro Luigi Poliani, Paolo Uva, Pier Luigi Mauri, Anna Villa, Anna Villa, Marita Bosticardo, Marita Bosticardo   +41 more
doaj   +1 more source

Alloactivation of Naïve CD4+CD8−CD25+T Regulatory Cells: Expression of CD8α Identifies Potent Suppressor Cells That Can Promote Transplant Tolerance Induction

Frontiers in Immunology, 2019
Therapy with alloantigen-specific CD4+CD25+ T regulatory cells (Treg) for induction of transplant tolerance is desirable, as naïve thymic Treg (tTreg) are not alloantigen-specific and are weak suppressor cells.
Nirupama D. Verma, Catherine M. Robinson, Nicole Carter, Paul Wilcox, Giang T. Tran, Chaunmin Wang, Alexandra Sharland, Masaru Nomura, Karren M. Plain, G. Alexander Bishop, Suzanne J. Hodgkinson, Bruce M. Hall   +11 more
doaj   +1 more source

MHC Class II Presentation in Autoimmunity

Cells, 2023
Antigen presentation by major histocompatibility complex class II (MHC-II) molecules is crucial for eliciting an efficient immune response by CD4+ T cells and maintaining self-antigen tolerance.
Irina A. Ishina, Maria Y. Zakharova, Inna N. Kurbatskaia, Azad E. Mamedov, Alexey A. Belogurov, Alexander G. Gabibov   +5 more
doaj   +1 more source