Results 21 to 30 of about 448,542 (245)

Mechanisms of Direct and Indirect Presentation of Self-Antigens in the Thymus

Frontiers in Immunology, 2022
The inevitability of evolution of the adaptive immune system with its mechanism of randomly rearranging segments of the T cell receptor (TCR) gene is the generation of self-reactive clones. For the sake of prevention of autoimmunity, these clones must be
Jiří Březina, Matouš Vobořil, Dominik Filipp   +2 more
doaj   +1 more source

Post-Aire Medullary Thymic Epithelial Cells and Hassall’s Corpuscles as Inducers of Tonic Pro-Inflammatory Microenvironment

Frontiers in Immunology, 2021
While there is convincing evidence on the role of Aire-positive medullary thymic epithelial cells (mTEC) in the induction of central tolerance, the nature and function of post-Aire mTECs and Hassall’s corpuscles have remained enigmatic. Here we summarize
Martti Laan, Ahto Salumets, Ahto Salumets, Annabel Klein, Kerli Reintamm, Rudolf Bichele, Hedi Peterson, Pärt Peterson   +7 more
doaj   +1 more source

Thymic Epithelial Cell Alterations and Defective Thymopoiesis Lead to Central and Peripheral Tolerance Perturbation in MHCII Deficiency

Frontiers in Immunology, 2021
Major Histocompatibility Complex (MHC) class II (MHCII) deficiency (MHCII-D), also known as Bare Lymphocyte Syndrome (BLS), is a rare combined immunodeficiency due to mutations in genes regulating expression of MHCII molecules.
Francesca Ferrua, Francesca Ferrua, Francesca Ferrua, Ileana Bortolomai, Elena Fontana, Elena Fontana, Dario Di Silvestre, Rosita Rigoni, Rosita Rigoni, Genni Enza Marcovecchio, Elena Draghici, Francesca Brambilla, Maria Carmina Castiello, Maria Carmina Castiello, Gloria Delfanti, Despina Moshous, Despina Moshous, Capucine Picard, Capucine Picard, Capucine Picard, Tom Taghon, Victoria Bordon, Ansgar S. Schulz, Catharina Schuetz, Catharina Schuetz, Silvia Giliani, Annarosa Soresina, Andrew R. Gennery, Andrew R. Gennery, Sara Signa, Sara Signa, Blachy J. Dávila Saldaña, Ottavia M. Delmonte, Luigi D. Notarangelo, Chaim M. Roifman, Pietro Luigi Poliani, Paolo Uva, Pier Luigi Mauri, Anna Villa, Anna Villa, Marita Bosticardo, Marita Bosticardo   +41 more
doaj   +1 more source

Alloactivation of Naïve CD4+CD8−CD25+T Regulatory Cells: Expression of CD8α Identifies Potent Suppressor Cells That Can Promote Transplant Tolerance Induction

Frontiers in Immunology, 2019
Therapy with alloantigen-specific CD4+CD25+ T regulatory cells (Treg) for induction of transplant tolerance is desirable, as naïve thymic Treg (tTreg) are not alloantigen-specific and are weak suppressor cells.
Nirupama D. Verma, Catherine M. Robinson, Nicole Carter, Paul Wilcox, Giang T. Tran, Chaunmin Wang, Alexandra Sharland, Masaru Nomura, Karren M. Plain, G. Alexander Bishop, Suzanne J. Hodgkinson, Bruce M. Hall   +11 more
doaj   +1 more source

MHC Class II Presentation in Autoimmunity

Cells, 2023
Antigen presentation by major histocompatibility complex class II (MHC-II) molecules is crucial for eliciting an efficient immune response by CD4+ T cells and maintaining self-antigen tolerance.
Irina A. Ishina, Maria Y. Zakharova, Inna N. Kurbatskaia, Azad E. Mamedov, Alexey A. Belogurov, Alexander G. Gabibov   +5 more
doaj   +1 more source

Thymic central tolerance takes centre stage in autoimmune disease [PDF]

The Lancet Regional Health. Western Pacific
Smaila Mulic-Al Bunni, Adam E. Handel
doaj   +2 more sources

CCR7 Modulates the Generation of Thymic Regulatory T Cells by Altering the Composition of the Thymic Dendritic Cell Compartment

Cell Reports, 2017
Upon recognition of auto-antigens, thymocytes are negatively selected or diverted to a regulatory T cell (Treg) fate. CCR7 is required for negative selection of auto-reactive thymocytes in the thymic medulla.
Zicheng Hu, Yu Li, Annemarie Van Nieuwenhuijze, Hilary J. Selden, Angela M. Jarrett, Anna G. Sorace, Thomas E. Yankeelov, Adrian Liston, Lauren I.R. Ehrlich   +8 more
doaj   +1 more source

Is T Cell Negative Selection a Learning Algorithm?

Cells, 2020
Our immune system can destroy most cells in our body, an ability that needs to be tightly controlled. To prevent autoimmunity, the thymic medulla exposes developing T cells to normal “self” peptides and prevents any responders from entering ...
Inge M. N. Wortel, Can Keşmir, Rob J. de Boer, Judith N. Mandl, Johannes Textor   +4 more
doaj   +1 more source

The Role of Viral Infections in the Onset of Autoimmune Diseases

Viruses, 2023
Autoimmune diseases (AIDs) are the consequence of a breach in immune tolerance, leading to the inability to sufficiently differentiate between self and non-self.
Bhargavi Sundaresan, Fatemeh Shirafkan, Kevin Ripperger, Kristin Rattay   +3 more
doaj   +1 more source

The Multifaceted Roles of B Cells in the Thymus: From Immune Tolerance to Autoimmunity

Frontiers in Immunology, 2021
The thymus is home to a significant number of resident B cells which possess several unique characteristics regarding their origin, phenotype and function.
Justine Castañeda, Yessia Hidalgo, Daniela Sauma, Mario Rosemblatt, Mario Rosemblatt, Mario Rosemblatt, María Rosa Bono, Sarah Núñez   +7 more
doaj   +1 more source