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The Thymus and Central Tolerance [PDF]
Clinical Immunology, 2000 T–cell differentiation in the thymus generates a peripheral repertoire of mature T cells that mounts strong responses to foreign antigens but is largely unresponsive to self–antigens. This state of specific immunological tolerance to self–components involves both central and peripheral mechanisms.
J, Sprent, H, Kishimoto
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RANK Signaling in the Differentiation and Regeneration of Thymic Epithelial Cells
Frontiers in Immunology, 2021 Thymic epithelial cells (TECs) provide essential clues for the proliferation, survival, migration, and differentiation of thymocytes. Recent advances in mouse and human have revealed that TECs constitute a highly heterogeneous cell population with ...
Magali Irla
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Molecular Therapy: Methods & Clinical Development, 2022 Insulin is the primary autoantigen (Ag) targeted by T cells in type 1 diabetes (T1D). Although biomarkers precisely identifying subjects at high risk of T1D are available, successful prophylaxis is still an unmet need.
Fabio Russo +8 more
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Back to Central Tolerance [PDF]
Immunity, 2004 The establishment and maintenance of immunological tolerance entails both central and peripheral mechanisms. The latter have been highlighted in the past several years, mostly because of great interest in the activities of regulatory T cells. However, an important role for central tolerance mechanisms has been reemphasized by recent results on human ...
Mathis, Diane, Benoist, Christophe
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Exploring the Origin and Antigenic Specificity of Maternal Regulatory T Cells in Pregnancy
Frontiers in Immunology, 2020 Successful pregnancy outcome is partially determined by the suppression of reactive effector T cells by maternal regulatory T cells (TRegs) at the maternal-fetal interface.
Soo Hyun Ahn +5 more
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Mechanisms of Direct and Indirect Presentation of Self-Antigens in the Thymus
Frontiers in Immunology, 2022 The inevitability of evolution of the adaptive immune system with its mechanism of randomly rearranging segments of the T cell receptor (TCR) gene is the generation of self-reactive clones. For the sake of prevention of autoimmunity, these clones must be
Jiří Březina +2 more
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Central Tolerance Matters [PDF]
Immunity, 2005 In this issue of Immunity, Anderson et al. provide another clue to the riddle that is Aire--why do human beings and mice lacking Aire develop diffuse and pathogenic autoimmunity? They find that Aire influences central tolerance not only by promoting the expression of peripheral self-proteins in thymic medullary epithelial cells (MECs) but also by ...
Goldrath, Ananda W., Hedrick, Stephen M.
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Frontiers in Immunology, 2021 While there is convincing evidence on the role of Aire-positive medullary thymic epithelial cells (mTEC) in the induction of central tolerance, the nature and function of post-Aire mTECs and Hassall’s corpuscles have remained enigmatic. Here we summarize
Martti Laan +7 more
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Thymic central tolerance takes centre stage in autoimmune disease [PDF]
The Lancet Regional Health. Western PacificSmaila Mulic-Al Bunni, Adam E. Handel
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