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The Thymus and Central Tolerance [PDF]
Clinical Immunology, 2000 T–cell differentiation in the thymus generates a peripheral repertoire of mature T cells that mounts strong responses to foreign antigens but is largely unresponsive to self–antigens. This state of specific immunological tolerance to self–components involves both central and peripheral mechanisms.
Hidehiro Kishimoto
exaly +5 more sources
Porcine Circovirus Type 2 Pathogenicity Alters Host’s Central Tolerance for Propagation [PDF]
Pathogens, 2020 Porcine circovirus type 2 (PCV2) infections and resulting diseases are a worldwide threat to pig production. PCV2 bears a uniqueness that allows for us to understand more about chronic infections and the immune system in general.
Xaver Sidler +4 more
doaj +2 more sources
Normothermic central hypovolemia tolerance reflects hyperthermic tolerance [PDF]
Clinical Autonomic Research, 2014 To test the hypothesis that those who are highly tolerant to lower body negative pressure (LBNP) while normothermic are also highly tolerant to this challenge while hyperthermic.Sixty pairs of normothermic and hyperthermic LBNP tests to pre-syncope were evaluated.
Zachary J, Schlader, Craig G, Crandall
openaire +5 more sources
On central max-point-tolerance graphs [PDF]
AKCE International Journal of Graphs and Combinatorics, 2020 Max-point-tolerance graphs (MPTG) were studied by Catanzaro et al. in 2017 and the same class of graphs were introduced in the name of p-BOX(1) graphs by Soto and Caro in 2015.
Sanchita Paul
doaj +2 more sources
The Role of Dendritic Cells in Central Tolerance [PDF]
Immune Network, 2015 Dendritic cells (DCs) play a significant role in establishing self-tolerance through their ability to present self-antigens to developing T cells in the thymus. DCs are predominantly localized in the medullary region of thymus and present a broad range of self-antigens, which include tissue-restricted antigens expressed and transferred from medullary ...
Oh, Jaehak, Shin, Jeoung-Sook
openaire +3 more sources
Central Tolerance or Central Adaptation? [PDF]
Scandinavian Journal of ImmunologyManjili MH.
openaire +4 more sources
Mediators of central tolerance [PDF]
Nature Reviews Immunology, 2015 Leavy Olive
exaly +2 more sources
Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance [PDF]
Immunological ReviewsLauren Ehrlich
exaly +2 more sources
A model of preferential pairing between epithelial and dendritic cells in thymic antigen transfer
eLife, 2022 Medullary thymic epithelial cells (mTECs), which produce and present self-antigens, are essential for the establishment of central tolerance. Since mTEC numbers are limited, their function is complemented by thymic dendritic cells (DCs), which transfer ...
Matouš Vobořil +8 more
doaj +1 more source
RANK Signaling in the Differentiation and Regeneration of Thymic Epithelial Cells
Frontiers in Immunology, 2021 Thymic epithelial cells (TECs) provide essential clues for the proliferation, survival, migration, and differentiation of thymocytes. Recent advances in mouse and human have revealed that TECs constitute a highly heterogeneous cell population with ...
Magali Irla
doaj +1 more source