Results 101 to 110 of about 12,015,384 (327)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Control strategy for microgrid under three-phase unbalance condition

Journal of Modern Power Systems and Clean Energy, 2016
Microgrid (MG) is generally developed at utility terminal which contains lots of unbalanced loads and distributed generations (DGs). The interaction between MG and the unbalance loads or DGs will degrades the control performance of interfaced inverter in
Hongtao Shi, Fang Zhuo, Hao Yi, Zhiqing Geng   +3 more
doaj   +1 more source

Transformations of matricial α-Stieltjes non-negative definite sequences

Linear Algebra and its Applications, 2013
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Fritzsche, Bernd, Kirstein, Bernd, Mädler, Conrad   +2 more
openaire   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Positive and Negative Sequence Control Strategies to Maximize the Voltage Support in Resistive–Inductive Grids During Grid Faults

IEEE transactions on power electronics, 2018
Grid faults are one of the most severe perturbations in power systems. During these extreme disturbances, the reliability of the grid is compromised and the risk of a power outage is increased.
Antonio Camacho, M. Castilla, J. Miret, L. de Vicuna, Ramón Guzmán   +4 more
semanticscholar   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Improvement of the transient negative-sequence rating formula for large generators based on the negative-sequence current component

International Transactions on Electrical Energy Systems, 2015
Summary This paper proposes an improved transient negative-sequence calculation formula for a large-capacity nuclear power generator system under unbalanced network conditions. Because of the disadvantages of traditional transient negative-sequence ratings, I2*2 t is concluded to be inadequate for rating the generator imbalance capability.
Bao-jun Ge, Wu Guo, Jian Guo, Yun-peng Gao, Ming-ze Li   +4 more
openaire   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Genome Sequences of Nine Gram-Negative Vaginal Bacterial Isolates

Genome Announcements, 2016
ABSTRACT The vagina is home to a wide variety of bacteria that have great potential to impact human health. Here, we announce reference strains (now available through BEI Resources) and draft genome sequences for 9 Gram-negative vaginal isolates from the taxa Citrobacter, Klebsiella, Fusobacterium, Proteus
Deitzler, Grace E, Ruiz, Maria J, Lu, Wendy, Weimer, Cory, Park, SoEun, Robinson, Lloyd S., Hallsworth-Pepin, Kymberlie, Wollam, Aye, Mitreva, Makedonka, Lewis, Warren G, Lewis, Amanda L   +10 more
openaire   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source