Results 61 to 70 of about 868,638 (260)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Study on the calculation method of electrical quantity for connection line open-phase operation of wind farm connected to MMC-HVDC Considering negative sequence current suppression

International Journal of Electrical Power & Energy Systems
The open-phase operation of the AC connection line connecting the wind farm and MMC generates negative sequence current in the system, which cause the overcurrent, overvoltage, power fluctuation and other problems.
Botong Li, Yuejin Dong, Xinru Jiao, Xiaolong Chen, Bin Li, Liang Ji   +5 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Hybrid current regulation of photovoltaic power integrated in railway traction power supply system

机车电传动, 2022
With the sustainable development of low-carbon transportation, it is imperative to develop and utilize the solar energy resources along the railway.
ZHANG Weiqiu, CHENG Peng, ZHANG Jingyan, HOU Dazhi, SUN Shijie, MA Jing   +5 more
doaj  

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Investigation on Stator Winding Inter-turns Short Circuit Fault Diagnosis

Journal of Harbin University of Science and Technology, 2018
On the basis of negative sequence current generation mechanism analysis of synchronous generator stator winding inter-turns short circuit，the method of detecting and diagnosing synchronous generator stator winding inter-turns short circuit is proposed ...
ZHAO Hong-sen, GE Bao-jun, TAO Da-jun, YANG Kun, XING Guang   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Control Method for Unbalanced Current in Grid Type Energy Storage Based on Negative Sequence Virtual Impedance

IEEE Open Journal of Circuits and Systems
Grid type energy storage has inertia support capability, and unbalanced grid voltage will cause grid type energy storage current fluctuation and active power fluctuation.
Li You, Liangli Xiong, Gang Han, Sheng Zhang, Zhijian Fang   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source