Results 101 to 110 of about 1,691,473 (292)

Correspondence between negative symptoms and potential sources of secondary negative symptoms over time. [PDF]

, 2017
There has been a debate in the literature about the distinction between primary and secondary negative symptoms of schizophrenia. Our aim was to study the associations between negative symptoms and potential sources of secondary negative symptoms over ...
Farreny, A, Farreny, Aida, Aida Farreny, Mark Savill, Savill, M, Priebe, S, Savill, Mark, Stefan Priebe, Priebe, Stefan   +8 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Negative Symptom Therapeutics [PDF]

Schizophrenia Bulletin, 2017
William T, Carpenter, Robert W, Buchanan
openaire   +2 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

The role of positive and negative childhood events in the risk of developing personality disorders [PDF]

, 2015
Existing research has predominantly focused on a limited range of childhood events and personality disorders, such as childhood maltreatment and borderline personality disorder.
Chua, M
core  

A cognitive model of the positive symptoms of psychosis [PDF]

, 2001
In the last 10 years a consensus has developed that the symptoms of psychosis may be better understood by linking the steps between the phenomenological experiences and social, psychological and neurobiological levels of explanation.
Garety, PA, Freeman, D, Fowler, D, Kuipers, E, Freeman, D., Bebbington, PE, Bebbington, P. E., Freeman, Daniel, Fowler, D. G., Bebbington, P, Garety, P; id_orcid, Garety, P. A., Kuipers, E; id_orcid, Kuipers, E.   +13 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Serum levels of S100B in patients with chronic schizophrenia during treatment augmentation with sarcosine: results of the double-blind, randomized, placebo-controlled PULSAR study

Frontiers in Pharmacology
IntroductionSarcosine (N-methylglycine) normalizes glutamatergic neurotransmission in schizophrenia and ameliorates primary negative symptoms. This amino acid may also directly or indirectly influence glial function and therefore levels of S100B, calcium-
Agnieszka Pawlak, Adam Wysokiński, Dominik Strzelecki   +2 more
doaj   +1 more source

Does emotion dysregulation mediate the relationship between behavioural inhibition and psychopathological symptoms? [PDF]

, 2011
Failure to address poor mental health during childhood and adolescence results in higher risk of suicide, substance misuse, self-harm, and lower achievement in education and employment (Richards et al., 2009).
Willie, Anne
core  

Effects of depressive symptoms on antecedents of lapses during a smoking cessation attempt: An ecological momentary assessment study [PDF]

, 2014
AIMS: To investigate pathways through which momentary negative affect and depressive symptoms affect risk of lapse during smoking cessation attempts. DESIGN: Ecological Momentary Assessment was carried out during two weeks after an unassisted smoking ...
Jeannette Brodbeck, Monica S. Bachmann, Hans Joerg Znoj, Brodbeck, Jeannette, Bachmann, Monica S., Znoj, Hans Joerg, Anna Brown, Brown, Anna, Znoj, Hans Jörg   +8 more
core   +1 more source