Results 111 to 120 of about 1,691,473 (292)

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

A Comparison of Methamphetamine-Induced Psychosis and Schizophrenia: A Review of Positive, Negative, and Cognitive Symptomatology

Frontiers in Psychiatry, 2018
Methamphetamine is a potent psychostimulant that can induce psychosis among recreational and chronic users, with some users developing a persistent psychotic syndrome that shows similarities to schizophrenia. This review provides a comprehensive critique
Travis A. Wearne, Travis A. Wearne, Jennifer L. Cornish   +2 more
doaj   +1 more source

Negative symptoms and negative schizophrenia.

Indian journal of psychiatry, 2011
This study determines the frequency distribution of prominent negative symptoms in a group of chronic, hospitalised schizophrenics. Thirty chronic Schizophrenic (D.S.M. III) patients were rated on the scale for Assessment of Negative Symptoms (SANS) and the prominent negative symptoms were correlated with age, sex and certain illness variables ...
S K, Chaturvedi, P S, Gopinath, P J, Mathai, A, Michael   +3 more
openaire   +1 more source

Cognitive behavioural therapy versus supportive therapy for persistent positive symptoms in psychotic disorders: the POSITIVE Study, a multicenter, prospective, single-blind, randomised controlled clinical trial [PDF]

, 2010
Background: It has been demonstrated that cognitive behavioural therapy (CBT) has a moderate effect on symptom reduction and on general well being of patients suffering from psychosis.
Andreas Bechdolf, Wölwer, Wolfgang, Buchkremer Gerhard, Klingberg, Stefan, Tilo Kircher, Bernhard W Müller, Engel Corinna, Bechdolf Andreas, Klingberg Stefan, Wagner Michael, Engel, Corinna, Buchkremer, Gerhard, Corinna Engel, Wittorf, Andreas, Meisner Christoph, Christoph Meisner, Sartory, Gudrun, Wiedemann, Georg, Michael Wagner, Müller, Bernhard W., Sartory Gudrun, Wagner, Michael, Meisner, Christoph, Stefan Klingberg, Georg Wiedemann, Wiedemann Georg, Herrlich Jutta, Wittorf Andreas, Jutta Herrlich, König Hans-Helmut, Herrlich, Jutta, Andreas Wittorf, Wolfgang Wölwer, König, Hans-Helmut, Bechdolf, Andreas, Kircher Tilo, Wölwer Wolfgang, Kircher, Tilo, Hans-Helmut König, Gerhard Buchkremer, Gudrun Sartory, Müller Bernhard W   +41 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Evaluation of Typical Antipsychotic Augmentation with Citalopram in Reduction of Negative Symptoms in Inpatient Schizophrenia in Ahvaz Golestan Hospital

Majalah-i ̒ilmī pizishkī-i jundī/shapūr, 2012
Background and Objective: The aim of this study was to evaluate the efficacy of citalopram added to typical antipsychotic for the treatment of negative symptoms of inpatients with schizophrenia disorder in Ahvaz Golestan hospital.
Masome Nazari Nasab, Nilofar Khajeddin, Abdol Amin Shanesaz Abbas Pezeshki   +2 more
doaj  

Persistent negative symptoms in schizophrenia: an overview [PDF]

, 2007
Persistent negative symptoms represent an alternative ap-proach for assessing negative symptoms in the context of clinical trials. Persistent negative symptoms are designed to capture those symptoms that lead to functional impair-ment but are currently ...
Robert W. Buchanan, Robert W Buchanan
core  

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

A validation of a new measure of activity in psychosis [PDF]

, 2006
Despite demonstrated relationships between activity and clinical change, we lack effective measures of time use in psychosis. Existing time budget measures of activity are demanding to complete, and thus unsuited to routine clinical use as measures of ...
Garety, PA, Dunn, Graham, Bebbington, P E, Freeman, D, Dunn, G., Dunn, G, Bebbington, PE, Jolley, S., Bebbington, P.E., Garety, P A; id_orcid, Ellett, L, Kuipers, E; id_orcid, Kuipers, Elizabeth, Fowler, DG, Garety, Philippa A., Fowler, G., Fowler, D G, Kuipers, E, Garety, P.A., Fowler, David G., Bebbington, Paul E., Freeman, D., Freeman, Daniel, Jolley, Suzanne, Jolley, S, Ellett, Lyn, Kuipers, E.   +26 more
core   +1 more source