Results 101 to 110 of about 1,297,038 (311)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
The problem of child neglect and homelessness in Russia
RUDN Journal of Public Administration, 2018 The article discusses and identifies the causes of child neglect and neglect in Russia. Also the necessary complex approach allowing to counteract this negative phenomenon which affects public authorities, the legislation, change of the General social and ...
A. M. Baturo
doaj +1 more source
Aysha King - medical treatment and the notion of 'neglect' [PDF]
, 2014 This article discusses the legal questions relating to parental rights to remove their child from hospital, and the international ...
Ressel, James
core
Gaia 1 cannot be a Thick Disk Galactic cluster
, 2018 In this note I show how the recently suggested membership of the open cluster Gaia 1 to the Galactic thick disk is based on incorrect assumptions about the structure of the disk itself, and neglect well-known observational evidences on the disk warp and ...
Carraro, Giovanni
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Religiously-Motivated Medical Neglect: A Response to Professors Levin, Jacobs, and Arora [PDF]
, 2016 This Response to Professors Levin, Jacobs, and Arora’s article To Accommodate or Not to Accommodate: (When) Should the State Regulate Religion to Protect the Rights of Children and Third Parties?
Coleman, Doriane Lambelet
core +2 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Process Evaluation of Georgia's Integrated Family Support Demonstration Project: Findings from First Year Implementation Efforts [PDF]
, 2008 This report summarizes findings from first year implementation efforts of the Georgia Department of Human Resources' Family Support Demonstration Project. The goal of the project was to reduce child abuse and neglect and improve child health by providing
Amanda Phillips Martinez +4 more
core