Results 41 to 50 of about 195,715 (304)
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Reasoning about commitments in multiple concurrent negotiations
Automated negotiation by software agents is a key enabling technology for agent mediated e-commerce. To this end, this paper considers an important class of such negotiations - namely those in which an agent engages in multiple concurrent bilateral ...
Thuc Duong Nguyen +5 more
core +2 more sources
UK-Japan Strategic Partnership in Light of Brexit [PDF]
The paper considers the UK policy towards Japan defined as its key ally in Asia. In light of upcoming Brexit, Great Britain tends to intensify the political dialogue with Tokyo in order to demonstrate alliances with «natural partners» all over the world.
Kira Godovanyuk
doaj +1 more source
Negotiating Effectively: Justice in International Environmental Negotiations [PDF]
Are negotiators who rely on justice principles in the process of bargaining and drafting agreements more—or rather less—effective than others? This article examines whether adherence to principles of procedural and distributive justice in negotiations contributes to more effective results, with a focus on international environmental negotiations ...
Albin, Cecilia, Druckman, Daniel
openaire +5 more sources
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Argentina and Germany: trade and trade policy
I will focus my presentation by highlighting and commenting on thefollowing topics: bilateral relations between Argentina, Germany and the EU, the ongoing EU-MERCOSUR negotiations and some other trade related and economic aspects.
Hans Jürgen Froese
doaj
Multifaceted nature of military negotiations
Research objectives and hypothesis/research questions The aim of the article is to emphasize the uniqueness and multidimensionality of military negotiations, to indicate potential opportunities in the area of development, to develop a specialized ...
Krzysztof Paweł Kałucki
doaj +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Culture and Workplace Mediation
The analysis of conflict and mediation in the field of organizations is an area of great theoretical and applied interest. In organizations with a high demographic diversity, it is necessary to analyse these processes using a cultural aproach.
Francisco J. Medina +2 more
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