Results 61 to 70 of about 101,309 (212)

Immunoglobulin A nephropathy is characterized by anticommensal humoral immune responses

JCI Insight, 2022
IgA nephropathy (IgAN) is a leading cause of kidney failure, yet little is known about the immunopathogenesis of this disease. IgAN is characterized by deposition of IgA in the kidney glomeruli, but the source and stimulus for IgA production are not ...
Elissa G. Currie, Bryan Coburn, Elisa A. Porfilio, Ping Lam, Olga L. Rojas, Jan Novak, Stuart Yang, Raad B. Chowdhury, Lesley A. Ward, Pauline W. Wang, Khashayar Khaleghi, James An, Sarah Q. Crome, Michelle A. Hladunewich, Sean J. Barbour, Daniel C. Cattran, Rulan S. Parekh, Christoph Licht, Rohan John, Rupert Kaul, Kenneth Croitoru, Scott D. Gray-Owen, David S. Guttman, Jennifer L. Gommerman, Heather N. Reich   +24 more
doaj   +1 more source

Commensal Neisseria Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance

Pathogens, 2020
Antimicrobial resistance in pathogenic Neisseria parallels reduced antimicrobial susceptibility in commensal Neisseria in certain populations, like men who have sex with men (MSM).
Christophe Van Dijck, Jolein G. E. Laumen, Sheeba S. Manoharan-Basil, Chris Kenyon   +3 more
doaj   +1 more source

Tryptophan‐Derived Microbial Metabolite Indole‐3‐Acetic Acid Ameliorates Periodontitis Through AhR/CYP1A1‐Mediated Macrophage Polarisation

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To investigate the association between tryptophan‐derived microbial metabolites and periodontitis, and to assess whether the differential tryptophan metabolite indole‐3‐acetic acid (IAA) could ameliorate periodontitis and elucidate its potential mechanism.
Shuyu Cheng, Shiyuan Song, Wen Zhang, Dan Qiao, Min Wang, Zhifeng Wang, Jiajie Pu, Wenrong Yang, Fuhua Yan, Yangheng Zhang   +9 more
wiley   +1 more source

Sweet complexity: O-linked protein glycosylation in pathogenic Neisseria

Frontiers in Cellular and Infection Microbiology
The genus Neisseria, which colonizes mucosal surfaces, includes both commensal and pathogenic species that are exclusive to humans. The two pathogenic Neisseria species are closely related but cause quite different diseases, meningococcal sepsis and ...
Bente Børud, Michael Koomey
doaj   +1 more source

Oral‐Rinse‐Sourced Microbiota in Oral Health and Diseases in a Representative US Adult Population: Implications for Diagnostics

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aims To investigate the associations between oral‐rinse microbiota and distinct oral conditions, and further evaluate its potential ability to distinguish periodontitis severity. Methods Oral‐rinse‐sourced microbiota with 16S ribosomal RNA sequencing from 3770 adults in US National Health and Nutrition Examination Survey 2009–2012 were ...
Yu Xie, Alejandro Artacho, Xiaoyu Yu, Mengning Bi, Hairui Li, Yuan Li, Andrea Roccuzzo, Alex Mira, Bob T. Rosier, Maurizio S. Tonetti   +9 more
wiley   +1 more source

Sulphonamide resistant commensal Neisseria with alterations in the dihydropteroate synthase can be isolated from carriers not exposed to sulphonamides

BMC Microbiology, 2002
Background Development of sulphonamide resistance in Neisseria meningitidis has been suggested to involve horizontal DNA-transfer from a commensal Neisseria species.
Swedberg Göte, Qvarnström Yvonne
doaj   +1 more source

CRISPR‐Enhanced RAA‐SHERLOCK Assay for Point‐of‐Care Detection of Cyprinid Herpesvirus‐3: Development, Validation and Clinical Application

Journal of Fish Diseases, EarlyView.
ABSTRACT Koi herpesvirus disease (KHVD), caused by Cyprinid herpesvirus‐3 (CyHV‐3), poses a significant threat to global aquaculture due to its high mortality rates and economic impact. Current diagnostic methods, such as PCR, are limited by equipment dependency and procedural complexity, hindering point‐of‐care (POC) applications.
Hatem Soliman, Naveed Akram, Mona Saleh
wiley   +1 more source

Management and Outcomes of Paediatric Bone and Joint Infections in a Regional Australian Hospital: A 10‐Year Retrospective Study

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim To evaluate clinical features, management, and outcomes of paediatric bone and joint infection (BJI) in a regional Australian hospital and assess weight‐based oral antibiotic prescribing. Methods We conducted a retrospective study of 171 children aged 0–18 years admitted with septic arthritis and/or osteomyelitis between 2011 and 2021 ...
Niall Johnston, Rani Bhatia, Coen Butters   +2 more
wiley   +1 more source

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source

Multi‐Omics Signatures of Periodontitis and Periodontal Therapy on the Oral and Gut Microbiome

Journal of Periodontal Research, EarlyView.
This multi‐omics study integrates shotgun metagenomics and NMR metabolomics to reveal coordinated microbial and metabolic signatures of periodontitis across the oral–gut axis. Non‐surgical periodontal therapy partially restored ecological and functional balance, supporting oral health as a modifiable driver of systemic microbial homeostasis.
Giacomo Baima, Shareef Dabdoub, Vivek Thumbigere‐Math, Davide Giuseppe Ribaldone, Gian Paolo Caviglia, Leonardo Tenori, Linda Fantato, Alessia Vignoli, Mario Romandini, Ilario Ferrocino, Mario Aimetti   +10 more
wiley   +1 more source