Results 81 to 90 of about 181,944 (331)

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source

Ceftriaxone-Resistant Neisseria gonorrhoeae, Canada, 2017

Emerging Infectious Diseases, 2018
We identified a ceftriaxone-resistant Neisseria gonorrhoeae isolate in a patient in Canada. This isolate carried the penA-60 allele, which differs substantially from its closest relative, mosaic penA XXVII (80% nucleotide identity).
B. Lefebvre, I. Martin, W. Demczuk, L. Deshaies, S. Michaud, A. Labbé, Marie-Claude Beaudoin, J. Longtin   +7 more
semanticscholar   +1 more source

Structure of the PII signal transduction protein of Neisseria meningitidis at 1.85 Ȃ resolution [PDF]

, 2006
Copyright @ 2006 International Union of CrystallographyThe PII signal transduction proteins GlnB and GlnK are implicated in the regulation of nitrogen assimilation in Escherichia coli and other enteric bacteria.
Alderton, D, Berrow, NS, Nichols, CE, Owens, RJ, Sainsbury, S, Saunders, NJ, Stammers, DK   +6 more
core   +1 more source

A Novel nor@DHB Matrix for Direct Microbial Analysis in Lung Cancer Tissues

Advanced Science, EarlyView.
Integrated matrix‐assisted laser desorption/ionization mass spectrometry workflow quantifies intratumoral microbes in lung cancer through lipopolysaccharide/lipid A extraction from biopsies. The novel ionic matrix called norharmane conjugated to 2,5‐dihydroxybenzoic acid enhances lipid A ionization, enabling direct detection of bacterial genera ...
Liang Shan, Xin Xu, Lin Huang, Dan Li, Yiran Deng, Xiangfei Xue, Susu Guo, Yiman Huang, Xiao Zhang, Yongchun Yu, Lifang Ma, Kun Qian, Jiayi Wang   +12 more
wiley   +1 more source

Antimicrobial activity of compounds identified by artificial intelligence discovery engine targeting enzymes involved in Neisseria gonorrhoeae peptidoglycan metabolism

Biological Research
Background Neisseria gonorrhoeae (Ng) causes the sexually transmitted disease gonorrhoea. There are no vaccines and infections are treated principally with antibiotics.
Ravi Kant, Hannah Tilford, Camila S. Freitas, Dayana A. Santos Ferreira, James Ng, Gwennan Rucinski, Joshua Watkins, Ryan Pemberton, Tigran M. Abramyan, Stephanie C. Contreras, Alejandra Vera, Myron Christodoulides   +11 more
doaj   +1 more source

Both Neisseria gonorrhoeae and Neisseria sicca Induce Cytokine Secretion by Infected Human Cells, but Only Neisseria gonorrhoeae Upregulates the Expression of Long Non-Coding RNAs

Pathogens, 2022
Bacteria of the Neisseria genus are Gram-negative diplococci including both pathogenic and commensal species. We focused on pathogenic Neisseria gonorrhoeae and commensal Neisseria sicca. We have demonstrated that not only N.
Jagoda Płaczkiewicz, Monika Adamczyk-Popławska, Ewa Kozłowska, Agnieszka Kwiatek   +3 more
doaj   +1 more source

Identification of Internationally Disseminated Ceftriaxone-Resistant Neisseria gonorrhoeae Strain FC428, China

Emerging Infectious Diseases, 2019
In 2016, we identified a ceftriaxone-resistant Neisseria gonorrhoeae isolate in China. The strain genotype was identical to the resistant clone FC428 that originated in Japan.
Shao-Chun Chen, Yan Han, Liu-feng Yuan, Xiaoyu Zhu, Yueping Yin   +4 more
semanticscholar   +1 more source

Virulence genes and previously unexplored gene clusters in four commensal Neisseria spp. isolated from the human throat expand the neisserial gene repertoire

Microbial Genomics, 2020
Commensal non-pathogenic Neisseria spp. live within the human host alongside the pathogenic Neisseria meningitidis and Neisseria gonorrhoeae and due to natural competence, horizontal gene transfer within the genus is possible and has been observed.
A. Calder, C. Menkiti, Aylin Çağdaş, Jefferson Lisboa Santos, Ricarda Streich, A. Wong, Amir H Avini, E. Bojang, K. Yogamanoharan, N. Sivanesan, Besma Ali, M. Ashrafi, A. Issa, T. Kaur, A. Latif, Hani A Sheik Mohamed, A. Maqsood, L. Tamang, E. Swager, Alex Stringer, Lori A. S. Snyder   +20 more
semanticscholar   +1 more source

In vitro and in vivo modification of Neisseria gonorrhoeae lipooligosaccharide epitope structure by sialylation. [PDF]

, 1990
After growth of gonococci in the presence of cytidine monophospho-N-acetyl-neuraminic acid (CMP-NANA), their 4.5-kD lipooligosaccharide (LOS) component was increased by approximately 400 daltons, whereas the LOS of strains lacking the 4.5-kD component ...
Apicella, MA, Cole, JA, Griffiss, JM, Lesse, AJ, Mandrell, RE, Morse, SA, Parsons, NJ, Shero, M, Smith, H, Sugai, JV   +9 more
core   +1 more source

Association Between Moraxella catarrhalis and Nodular Lymphocyte‐Predominant Hodgkin Lymphoma

American Journal of Hematology, EarlyView.
ABSTRACT Nodular lymphocyte‐predominant Hodgkin Lymphoma (NLPHL) may be an antigen‐driven malignancy. Recent studies demonstrated that in NLPHL patients, lymphoma B‐cell receptor can bind proteins derived from Moraxella catarrhalis (MC) and Rothia mucilaginosa (RM). We examined whether MC and RM can be detected in NLPHL lymph nodes.
Izidore S. Lossos, Xiaoyu Jiang, Krishna Patel, Kamilia N. Moalem, Jordan Laser, Joo Y. Song, Anamarija M. Perry, Jennifer R. Chapman   +7 more
wiley   +1 more source