Results 81 to 90 of about 12,304,496 (201)

A Prospective Study of Etiology of Childhood Acute Bacterial Meningitis, Turkey

Emerging Infectious Diseases, 2008
Determination of the etiology of bacterial meningitis and estimating cost of disease are important in guiding vaccination policies. To determine the incidence and etiology of meningitis in Turkey, cerebrospinal fluid (CSF) samples were obtained ...
Mehmet Ceyhan, Inci Yildirim, Paul Balmer, Ray Borrow, Bunyamin Dikici, Mehmet Turgut, Nese Kurt, Aysel Aydogan, Cigdem Ecevit, Yasar Anlar, Ozlem Gulumser, Gonul Tanir, Nuran Salman, Nezahat Gurler, Nevin Hatipoglu, Mustafa Hacimustafaoglu, Solmaz Celebi, Yavuz Coskun, Emre Alhan, Umit Celik, Yildiz Camcioglu, Gulten Secmeer, Deniz Gur, Steve J. Gray   +23 more
doaj   +1 more source

Application of Causal Inference to Establish Assay Effect in the Absence of a Bridging Study: A Case Study of MenACWY‐CRM Conjugate Vaccine Data

Pharmaceutical Statistics, Volume 25, Issue 2, March/April 2026.
ABSTRACT During a vaccine development program, if the assay used to measure immunological endpoints is changed, ideally, a bridging study is performed to establish the relationship between results obtained with the new and previous assay. However, this is not always feasible, and when bridging study data are absent, this can limit the ability to use ...
Meike Adani, Silvia Noirjean, Andrea Callegaro, Pavitra Keshavan, Marco Costantini   +4 more
wiley   +1 more source

Review and Recommendations of the Neisseria meningitidis Serogroup B Vaccine

General Medicine: Open Access, 2015
Background: Meningococcal disease (MD) has high incidence in children less than four years followed by teenagers and Young adults, with high mortality and comorbidities. Objectives: To review the recommendations of Neisseria meningitidis Serogroup B Vaccine around the world.
openaire   +1 more source

Extensive Genetic Diversity and Epidemiological Patterns of Factor H-Binding Protein Variants among Neisseria meningitidis in China

Microorganisms
Factor H-binding protein (fHbp) is a virulence factor expressed by Neisseria meningitidis (N. meningitidis), the primary causative agent of invasive meningococcal disease (IMD) in humans.
Zhizhou Tan, Juan Xu, Jie Che, Li Xu, Dongshan Yan, Maojun Zhang, Zhujun Shao   +6 more
doaj   +1 more source

Meningococcal Serogroup Y Meningitis Reveals Inborn Factor B Deficiency

European Journal of Immunology, Volume 56, Issue 2, February 2026.
We report a novel case of complete complement Factor B deficiency revealed by invasive meningococcal disease. Using combined functional and genetic analyses, we demonstrate that loss of Factor B abolishes alternative pathway activity despite detectable protein levels. These findings provide a mechanistic framework relevant to complement diagnostics and
Camille Bougeard, Eléonore Eskander, Paula Vieira Martins, Joan Bitan, Julia Roquigny, Christèle Kyheng, Tamazoust Guiddir, Véronique Frémeaux‐Bacchi, Cécile Gonnin, Carine ElSissy   +9 more
wiley   +1 more source

Complete Genome Sequence of Neisseria meningitidis Serogroup B Strain MC58

Science, 2000
The 2,272,351–base pair genome of Neisseria meningitidis strain MC58 (serogroup B), a causative agent of meningitis and septicemia, contains 2158 predicted coding regions, 1158 (53.7%) of which were assigned a biological role. Three major islands of horizontal DNA transfer were identified; two of these contain genes
Tettelin H., Saunders N. J., Heidelberg J., Jeffries A. C., Nelson K. E., Eisen J. A., Ketchum K. A., Hood D. W., Peden J. F., Dodson R. J., Nelson W. C., Gwinn M. L., DeBoy R., Peterson J. D., Hickey E. K., Haft D. H., Salzberg S. L., White O., Fleischmann R. D., Dougherty B. A., Mason T., Ciecko A., Parksey D. S., Blair E., Cittone H., Clark E. B., Cotton M. D., Utterback T. R., Khouri H., Qin H., Vamathevan J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H. O., Fraser C. M., Moxon E. R., Rappuoli R., Craig Venter J.   +41 more
openaire   +3 more sources

Molecular Diagnosis of Bacterial Meningitis in Ethiopia: A Narrative Review of Current Evidence and Implementation Gaps

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Background Bacterial meningitis (BM) remains a significant public health concern in Ethiopia, particularly due to diagnostic challenges posed by limited laboratory infrastructure, late patient presentation, and technical skills required for cerebrospinal fluid (CSF) sampling.
Lema Ayele Tenkolu, Fikadu Balcha, Shweta Negi   +2 more
wiley   +1 more source

Microarray genomotyping of key experimental strains of Neisseria gonorrhoeae reveals gene complement diversity and five new neisserial genes associated with Minimal Mobile Elements [PDF]

, 2004
This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL - © 2004 Snyder et al; licensee BioMed Central Ltd ...
Snyder, Lori A S, John K Davies, Snyder, LAS, Saunders, Nigel, Lori AS Snyder, Davies, John K, Saunders, NJ, Saunders, Nigel J., Davies John K, Snyder, Lori A. S., Snyder, LA, Davies, JK, Saunders Nigel J, Nigel J Saunders, Saunders, Nigel J, Snyder Lori AS   +15 more
core   +1 more source

Development and characterization of murine monoclonal antibody specific for the P1.4 PorA proteins from strain B:4:P1.(7b).4. of Neisseria meningitidis

VacciMonitor, 2011
Neisseria meningitidis isolates are conventionally classified by serosubtyping that characterizes the reactivities of the PorA outer membrane protein variable-region epitopes with monoclonal antibodies.
María Elena Pérez, Ramón Barberá, Francisco Domínguez , Oscar Otero, Mercedes Gutiérrez, Gustavo Falero, Grethel Reyes, Franklin Sotolongo, Gustavo Sierra   +8 more
doaj  

Expression of class 5 antigens by meningococcal strains obtained from patients in Brazil and evaluation of two new monoclonal antibodies

Brazilian Journal of Infectious Diseases
Determining the profile of antigen expression among meningococci is important for epidemiologic surveillance and vaccine development. To this end, two new mouse monoclonal antibodies (MAbs) have been derived against Neisseria meningitidis proteins (class
Elizabeth N. De Gaspari, Wendell D. Zollinger   +1 more
doaj   +1 more source