Microbiota Medicine Research, EarlyView.ABSTRACT The growing recognition of the microbiome's role in human health has propelled the emergence of microbiota medicine—a new discipline integrating microbiology, multi‐omics, and clinical science. Advances in sequencing, data integration, and interventions such as fecal microbiota transplantation (FMT) have transitioned the field from ...
Min Dai +6 more
wiley +1 more source
Cost-Effectiveness of Perioperative Immune Checkpoint Therapy for NSCLC in Japan, the United States, and Brazil. [PDF]
JTO Clin Res RepFujioka M +8 more
europepmc +1 more source
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objective Artificial intelligence (AI) has advanced to simultaneously process visual, auditory, and textual inputs, providing users with “multimodal” AI. Given the clinical integration potential of these tools, otolaryngologists must stay informed. This study reviews current literature on applications of multimodal AI in otolaryngology.
Ying Jie Li +5 more
wiley +1 more source
Toward organ preservation in thoracic malignancies: why interpretable multimodal radiopathomics matters in the neoadjuvant immunotherapy era. [PDF]
J Immunother CancerJiang W, Fan Y, Zhao J, Zeng J, Wu L.
europepmc +1 more source
Topological analysis of the human lymph node reticular network predicts outcome in breast cancer
The Journal of Pathology, EarlyView.Abstract Axillary LNs (ALNs) initiate immune responses in breast cancer (BC) but how and when ALNs become dysfunctional, facilitating metastasis, is unclear. The fibroblastic reticular cell (FRC) network within ALNs provides structural support and mediates immune homeostasis, but we have yet to elucidate whether this network changes during BC ...
Amy M Llewellyn +7 more
wiley +1 more source
Differential Survival Outcomes of Satisfactory Tumour Response (ypStage I) Following Neoadjuvant Chemoradiotherapy Versus Neoadjuvant Immunochemotherapy of Oesophageal Squamous Cell Cancer. [PDF]
Eur J Cardiothorac SurgHuang Y +9 more
europepmc +1 more source
Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives
Precision Medical Sciences, EarlyView.Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley +1 more source
FDA Approval Summary: Durvalumab for the Treatment of Adult Patients with Muscle-Invasive Bladder Cancer. [PDF]
Clin Cancer ResMirkheshti N +8 more
europepmc +1 more source
Precision Radiation Oncology, EarlyView.The combination of immune checkpoint inhibitors (ICIs) and radiotherapy synergistically enhances efficacy through an “antigen release‐immune activation” closed‐loop mechanism, significantly improving outcomes in solid tumors (e.g., lung cancer, melanoma).
Guiling Song +5 more
wiley +1 more source
Locoregional control of downstaged breast-conserving surgery after neoadjuvant chemotherapy: A propensity-matched study in Chinese patients. [PDF]
BreastZhang D +5 more
europepmc +1 more source