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Local immunotherapy for the treatment of cancer: scientific advances and clinical potential. [PDF]
Kaufman HL, de Gruijl TD.
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Risk factors for distant recurrence in patients with rectal cancer supporting selection for total neoadjuvant therapy. [PDF]
Slipsager AB +10 more
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Neoadjuvant Therapy for Melanoma
Surgical Oncology Clinics of North America, 2020With the universal adoption of immune checkpoint blockade and agents targeting BRAF-mutated melanomas in the metastatic setting, numerous clinical trials have evaluated these agents in the neoadjuvant setting. These smaller trials have shown promising results with high pathologic response rates and acceptable safety.
Michael C, Lowe, Ragini R, Kudchadkar
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Neoadjuvant Chemoradiotherapy and Neoadjuvant Chemotherapy
2017Rectal cancer is a challenging disease to treat, and its optimal management requires a multidisciplinary approach with involvement of surgical, medical, and radiation oncologists.
Mohamed E. Salem, John L. Marshall
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Neoadjuvant Aortic Endografting
Annals of Vascular Surgery, 2009The advent and success of endovascular repair of abdominal aneurysms led to the development of catheter-based techniques to treat thoracic aortic pathology. Such diseases, including thoracic aortic aneurysms, acute and chronic type B dissections, penetrating aortic ulcers, and traumatic aortic transection, challenge surgeons to perform complex open ...
G, Roche-Nagle +4 more
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Neoadjuvant Chemoimmunotherapy
Thoracic Surgery ClinicsNeoadjuvant treatment strategies for early-stage resectable non-small cell lung cancer (NSCLC) are evolving with the introduction of immune checkpoint inhibitors. While traditional neoadjuvant chemotherapy has offered modest survival benefit, recent trials show that combining chemotherapy with immunotherapy significantly increases pathologic complete ...
Gökce, Yavuz, Jonathan D, Spicer
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Neoadjuvant Chemotherapy for Osteosarcoma of the Extremity
Clinical Orthopaedics and Related Research, 1987Eighty-five patients with nonmetastatic, high-grade osteosarcoma of an extremity received intravenous methotrexate and intraarterial cisplatinum and then a definitive surgical resection. The preliminary results suggest that preoperative chemotherapy with a delayed surgical resection is as safe as immediate surgery. More patients are candidates for limb
BACCI G +8 more
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Biomarkers in Neoadjuvant Trials
2008Neoadjuvant chemotherapy trials have consistently reported lower response rates in patients with hormone receptor-positive (HR+) breast cancers when compared with hormone receptor-negative (HR ) tumors. There are now many pharmacologic agents on the market for both the treatment and the prevention of breast cancer, while even more agents are being ...
Regina M, Fearmonti +2 more
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