Results 61 to 70 of about 209,106 (262)
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, EarlyView.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
Breast cancer heterogeneity within the neoadjuvant window [PDF]
, 2019 Breast cancer affects ~55,000 women in the UK annually. Key to the reliable management of the disease is robust characterisation of an individual’s tumour, to best determine the most appropriate treatment and likely prognosis.
Pearce, Dominic
core +3 more sources
Tumor regression grading of gastrointestinal cancers after neoadjuvant therapy. [PDF]
, 2017 Neoadjuvant therapy has been successfully introduced in the treatment of locally advanced gastrointestinal malignancies, particularly esophageal, gastric, and rectal cancers.
Rupert Langer +3 more
core +2 more sources
Advanced Science, EarlyView.Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin +20 more
wiley +1 more source
Longitudinal Morphomolecular Monitoring of Head and Neck Carcinogenesis
Advanced Science, EarlyView.A miniaturized endoscopic probe that integrates Raman spectroscopy and optical coherence tomography, enabling simultaneous molecular and structural imaging of living tissue, was developed. Applied longitudinally in a mouse model of head and neck cancer, the system tracks disease progression from precancerous lesions to invasive cancer.
Jianrong Qiu +7 more
wiley +1 more source
European Journal of Breast Health, 2014 Objective:The reliability of traditional methods such as physical examination, ultrasonography (US) and mammography is limited in determining the type of treatment response in patients with neoadjuvant chemotherapy (NAC) application for locally advanced ...
Naciye Sinem Gezer +5 more
doaj +1 more source
Advanced Science, EarlyView.Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger +8 more
wiley +1 more source
Prognostic Model of D2 Radical Gastrectomy Combined with Neoadjuvant Chemotherapy for Gastric Cancer
, 2023 Guangjun Wang,1,* Yinghua Tan,2,* Yongjie Jiang,1 Jia Liu,1 Yuanhui Su,3 Zhengang Sun,4 Bo Liu3,5 1Department of General Surgery, Qingdao West Coast New Area Central Hospital, Qingdao, Shandong, People’s Republic of China; 2Department of ...
Jiang Y +6 more
core
Advanced Science, EarlyView.Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang +9 more
wiley +1 more source
Predictive factors of neoadjuvant immune checkpoint blockade in melanoma
Human Vaccines & Immunotherapeutics, 2022 This review describes the current body of literature and ongoing clinical trials examining neoadjuvant immune checkpoint inhibitors (ICI) for patients with resectable stage III and IV melanoma.
Melissa Sarver +4 more
doaj +1 more source