Results 1 to 10 of about 4,732,777 (361)

Neoadjuvant therapy

Journal of the Chinese Medical Association, 2023
effect ...
Peng-Hui, Wang, Szu-Ting, Yang, Chia-Hao, Liu   +2 more
openaire   +3 more sources

Neoadjuvant therapy

memo - Magazine of European Medical Oncology
Summary Neoadjuvant therapy (NAT) for early breast cancer was first introduced in the 1980s to downstage large, inoperable tumors, and thereby enable less extensive surgical resections. Beyond its surgical benefits, NAT offers the unique advantage of assessing treatment response in vivo, informing subsequent adjuvant strategies, and ...
Vanessa Castagnaviz, Simon Peter Gampenrieder   +1 more
semanticscholar   +4 more sources

Neoadjuvant therapy with immune checkpoint blockade, antiangiogenesis, and chemotherapy for locally advanced gastric cancer

Nature Communications, 2023
Immune checkpoint inhibitors and antiangiogenic agents have shown some activity in patients with late-stage gastric cancer. Here the authors report the results of a phase II trial of neoadjuvant anti-PD1 (camrelizumab), antiangiogenic agent (apatinib ...
Song Li, Wenbin Yu, Fei Xie, Haitao Luo, Zhimin Liu, Weiwei Lv, Duan-Bo Shi, Dexin Yu, P. Gao, Cheng Chen, Meng Wei, Wenhao Zhou, Jiaqian Wang, Zhikun Zhao, Xin Dai, Qian Xu, Xue Zhang, Miao Huang, Kai Huang, Jian Wang, Jisheng Li, Lei Sheng, Lian Liu   +22 more
semanticscholar   +1 more source

Association between pathologic response and survival after neoadjuvant therapy in lung cancer

Nature Medicine, 2023
Analysis of the phase 3 CheckMate 816 trial shows that the depth of pathologic response as assessed by percent residual viable tumor is correlated with event-free survival following neoadjuvant immunotherapy plus chemotherapy, supporting pathologic ...
J. Deutsch, A. Cimino-Mathews, Elizabeth Thompson, Mariano Provencio, P. Forde, Jonathan D Spicer, N. Girard, Daphne Wang, Robert A Anders, Edward Gabrielson, Peter B Illei, Jaroslaw Jedrych, Ludmila Danilova, J. Sunshine, Keith M Kerr, Mia Tran, J. Bushong, Junliang Cai, V. Devas, J. Neely, D. Balli, T. Cottrell, Alexander S. Baras, Janis M. Taube   +23 more
semanticscholar   +1 more source

Total neoadjuvant therapy for rectal cancer: a guide for surgeons

Canadian journal of surgery. Journal canadien de chirurgie, 2023
Summary The modern management of rectal cancers continues to evolve. With the release of data from new landmark randomized controlled trials (RAPIDO, PRODIGE-23), total neoadjuvant therapy (TNT) has moved to the forefront of locally advanced rectal ...
Garrett Johnson, Jason Park, R. Helewa, B. Goldenberg, M. Nashed, E. Hyun   +5 more
semanticscholar   +1 more source

Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Patients With Locally Advanced Rectal Cancer: Long-term Results of the CAO/ARO/AIO-12 Randomized Clinical Trial.

JAMA Oncology, 2021
Importance Total neoadjuvant therapy has been increasingly adopted for multimodal rectal cancer treatment. The optimal sequence of chemoradiotherapy (CRT) and chemotherapy needs to be established.
E. Fokas, A. Schlenska-Lange, B. Polat, G. Klautke, G. Grabenbauer, R. Fietkau, T. Kuhnt, L. Staib, T. Brunner, A. Grosu, S. Kirste, L. Jacobasch, M. Allgäuer, M. Flentje, Christoph‐Thomas Germer, R. Grützmann, G. Hildebrandt, M. Schwarzbach, W. Bechstein, H. Sülberg, T. Friede, J. Gaedcke, M. Ghadimi, R. Hofheinz, C. Rödel   +24 more
semanticscholar   +1 more source

Comprehensive landscape of resistance mechanisms for neoadjuvant therapy in esophageal squamous cell carcinoma by single-cell transcriptomics

Signal Transduction and Targeted Therapy, 2023
Dear Editor , Preoperative neoadjuvant therapy combined with surgical resection is the standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC). However, more than half of patients having a partial response to neoadjuvant therapy,
Yushang Yang, Yanguo Li, Hao-Peng Yu, Z. Ding, Longqi Chen, Xiaoxi Zeng, Shunmin He, Q. Liao, Yi Zhao, Yong Yuan   +9 more
semanticscholar   +1 more source

Total neoadjuvant therapy (TNT) versus standard neoadjuvant chemoradiotherapy for locally advanced rectal cancer: a systematic review and meta-analysis.

The Oncologist, 2021
OBJECTIVE & BACKGROUND Total neoadjuvant therapy (TNT) is a novel approach for locally advanced rectal cancer (LARC), which attempts to deliver both systemic chemotherapy and neoadjuvant chemoradiotherapy prior to surgery.
Shuang Liu, Ting Jiang, Lin Xiao, Shanfei Yang, Qing Liu, Yuan-hong Gao, Gong Chen, W. Xiao   +7 more
semanticscholar   +1 more source

Neoadjuvant Chemotherapy, Endocrine Therapy, and Targeted Therapy for Breast Cancer: ASCO Guideline

Journal of Clinical Oncology, 2021
PURPOSE To develop guideline recommendations concerning optimal neoadjuvant therapy for breast cancer. METHODS ASCO convened an Expert Panel to conduct a systematic review of the literature on neoadjuvant therapy for breast cancer and provide recommended
L. Korde, M. Somerfield, L. Carey, J. Crews, N. Denduluri, E. Hwang, S. Khan, S. Loibl, E. Morris, Alejandra T. Perez, M. Regan, P. Spears, Preeti K. Sudheendra, W. Symmans, R. Yung, Brittany E. Harvey, D. Hershman   +16 more
semanticscholar   +1 more source

Use of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: Initial Results From the Pembrolizumab Arm of a Phase 2 Randomized Clinical Trial.

JAMA Oncology, 2021
Importance Total neoadjuvant therapy (TNT) is often used to downstage locally advanced rectal cancer (LARC) and decrease locoregional relapse; however, more than one-third of patients develop recurrent metastatic disease.
O. Rahma, G. Yothers, T. Hong, M. Russell, Y. You, W. Parker, S. Jacobs, L. Colangelo, P. C. Lucas, M. Gollub, W. Hall, L. Kachnic, Namrata Vijayvergia, M. O'Rourke, B. Faller, R. Valicenti, T. Schefter, K. Moxley, R. Kainthla, P. Stella, E. Sigurdson, N. Wolmark, T. George   +22 more
semanticscholar   +1 more source