Results 261 to 270 of about 2,703,409 (308)

Neoadjuvant Therapy for Melanoma

Surgical Oncology Clinics of North America, 2020
With the universal adoption of immune checkpoint blockade and agents targeting BRAF-mutated melanomas in the metastatic setting, numerous clinical trials have evaluated these agents in the neoadjuvant setting. These smaller trials have shown promising results with high pathologic response rates and acceptable safety.
Michael C, Lowe, Ragini R, Kudchadkar
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Neoadjuvant Therapy for Rectal Cancer

Surgical Oncology Clinics of North America, 2022
The treatment of locally advanced rectal cancer is challenging and requires a multidisciplinary approach. Neoadjuvant treatment has improved local control by the combination of radiotherapy, surgery, and chemotherapy. However, neoadjuvant treatment has not yet been shown to improve overall survival and is associated with toxicities and late sequelae ...
Felipe F, Quezada-Diaz, J Joshua, Smith
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Neoadjuvant therapy for pancreatic cancer

Nature Reviews Clinical Oncology, 2023
Patients with localized pancreatic ductal adenocarcinoma (PDAC) are best treated with surgical resection of the primary tumour and systemic chemotherapy, which provides considerably longer overall survival (OS) durations than either modality alone. Regardless, most patients will have disease relapse owing to micrometastatic disease.
Christoph Springfeld, Cristina R. Ferrone, Matthew H. G. Katz, Philip A. Philip, Theodore S. Hong, Thilo Hackert, Markus W. Büchler, John Neoptolemos   +7 more
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The Role of Neoadjuvant Therapy in Melanoma

Current Oncology Reports, 2020
Neoadjuvant therapy in melanoma is an area of active investigation with numerous completed and ongoing trials studying a variety of therapeutic interventions utilizing diverse designs. Here, we review completed and ongoing neoadjuvant trials in melanoma, discuss endpoint assessment, and highlight biomarker development in this context.High-risk ...
Zahra R, Kelly, Vikram C, Gorantla, Diwakar, Davar   +2 more
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Neoadjuvant Therapy for Melanoma

Advances in Surgery
The advent of potent immune checkpoint inhibitor and other targeted therapies has transformed neoadjuvant therapy into a potentially more efficacious treatment strategy overall. Administering immunotherapy before surgery can enhance the immune system's ability to target melanoma cells, utilize neoantigens, and treat clinically occult and metastatic ...
Margaret H, O'Connor, Isabel, DeLaura, Georgia M, Beasley   +2 more
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Neoadjuvant therapy in cancer treatment

Cancer, 1993
Neoadjuvant therapy has come to play an increasingly prominent role in the treatment of cancer. Originally defined as systemic therapy given before local treatment, the concept has been extended to include radiation therapy given before surgery. Potential advantages include improved local and distant control, direct evaluation, and organ-sparing ...
E L, Trimble, R S, Ungerleider, J A, Abrams, R S, Kaplan, E G, Feigal, M A, Smith, C L, Carter, M A, Friedman   +7 more
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Neoadjuvant Endocrine Therapy Models

2006
Neoadjuvant therapy is therapy administered before surgical intervention and while the tumor remains in the breast. It may be given to treat large, locally advanced tumors, with the aim of shrinking them and thus making their surgical excision either simply possible or less radical.
Juliette, Murray, William R, Miller, J Michael, Dixon   +2 more
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Neoadjuvant Therapy for Gastric Cancer

Advances in Surgery, 2008
Complete surgical resection remains the primary curative treatment option for patients with early stage gastric adenocarcinoma appropriately staged with an adequate lymphadenectomy. Unfortunately, only 40% patients who undergo curative resection at the authors' institution will have early stage (i.e., stage IA or T2N0M0) disease; thus, the majority of ...
Michael G, House, Murray F, Brennan
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Neoadjuvant Therapy Versus Adjuvant Therapy

2012
This chapter describes an aspect of study design for oncology clinical trials (and in daily oncology clinical practice), namely, the choice of neoadjuvant therapy, which occurs before surgery, and adjuvant therapy, which occurs after therapy. Neoadjuvant therapy and adjuvant therapy each have specific advantages.
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Neoadjuvant Therapy in Pancreatic Cancer

Cancer Investigation, 2007
Pancreatic cancer is the fourth leading cause of cancer deaths in the United States. Surgical resection offers the only hope of cure, though the addition of chemoradiation in the adjuvant setting has been shown to improve survival over surgery alone. Many patients are unable to receive adjuvant therapy due to prolonged postoperative recovery.
Roderick M, Quiros, Kimberly M, Brown, John P, Hoffman   +2 more
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