Results 271 to 280 of about 144,610 (311)

Neoadjuvant Therapy in Esophageal Cancer

Thoracic Surgery Clinics, 2022
Locally advanced esophageal cancer has a dismal prognosis. Surgery remains the cornerstone treatment with 5-year survival rates of approximately 12-39%. Rates of local failure and distant metastases are high following surgical resection of locally advanced tumors.
Shirley, Lewis, Jelena, Lukovic
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Neoadjuvant therapy in cancer treatment

Cancer, 1993
Neoadjuvant therapy has come to play an increasingly prominent role in the treatment of cancer. Originally defined as systemic therapy given before local treatment, the concept has been extended to include radiation therapy given before surgery. Potential advantages include improved local and distant control, direct evaluation, and organ-sparing ...
E L, Trimble, R S, Ungerleider, J A, Abrams, R S, Kaplan, E G, Feigal, M A, Smith, C L, Carter, M A, Friedman   +7 more
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Neoadjuvant Endocrine Therapy Models

2006
Neoadjuvant therapy is therapy administered before surgical intervention and while the tumor remains in the breast. It may be given to treat large, locally advanced tumors, with the aim of shrinking them and thus making their surgical excision either simply possible or less radical.
Juliette, Murray, William R, Miller, J Michael, Dixon   +2 more
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Neoadjuvant Therapy for Gastric Cancer

Advances in Surgery, 2008
Complete surgical resection remains the primary curative treatment option for patients with early stage gastric adenocarcinoma appropriately staged with an adequate lymphadenectomy. Unfortunately, only 40% patients who undergo curative resection at the authors' institution will have early stage (i.e., stage IA or T2N0M0) disease; thus, the majority of ...
Michael G, House, Murray F, Brennan
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Neoadjuvant Therapy in Pancreatic Cancer

Cancer Investigation, 2007
Pancreatic cancer is the fourth leading cause of cancer deaths in the United States. Surgical resection offers the only hope of cure, though the addition of chemoradiation in the adjuvant setting has been shown to improve survival over surgery alone. Many patients are unable to receive adjuvant therapy due to prolonged postoperative recovery.
Roderick M, Quiros, Kimberly M, Brown, John P, Hoffman   +2 more
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Neoadjuvant Therapy of Esophageal Cancer

Surgical Oncology Clinics of North America, 1997
Locally advanced esophageal cancer, potentially curable with surgery or radiotherapy-based treatment, has a poor prognosis because of the eventual development of systemic metastatic disease in the majority of patients. Local recurrence of disease after local treatment modalities is equally problematic.
D H, Ilson, M, Bains, R J, Ginsberg, D P, Kelsen   +3 more
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Neoadjuvant Therapy in Rectal Cancer

Diseases of the Colon & Rectum, 2011
The optimal type of neoadjuvant therapy regimen in rectal cancer is contentious.This study aimed to review the impact of neoadjuvant therapy on oncological outcomes and complications (short and long term) in patients undergoing total mesorectal excision for rectal cancer.An electronic search of MEDLINE, PubMed, EMBASE, and the Cochrane Database of ...
Fergal J, Fleming, Lars, Påhlman, John R T, Monson   +2 more
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Neoadjuvant therapy for resectable melanoma

Clinical & Experimental Metastasis
The standard of care for patients with resectable stage III/IV melanoma classically included upfront resection with adjuvant therapy. However, in more recent years, the amount of systemic therapies available for neoadjuvant use for these patients has increased.
Cimarron E. Sharon, Giorgos C. Karakousis   +1 more
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Neoadjuvant Therapy Versus Adjuvant Therapy

2012
This chapter describes an aspect of study design for oncology clinical trials (and in daily oncology clinical practice), namely, the choice of neoadjuvant therapy, which occurs before surgery, and adjuvant therapy, which occurs after therapy. Neoadjuvant therapy and adjuvant therapy each have specific advantages.
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NEOADJUVANT THERAPY OF ESOPHAGEAL CARCINOMA

Chest Surgery Clinics of North America, 1994
To quote Steiger, the "multimodality treatment of esophageal cancer brings creativity and imagination to a field of medicine plagued with failure." However, acceptance of neoadjuvant chemotherapy or chemoradiotherapy as routine must await the results of large phase III studies. Even with a positive response, many questions will remain.
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