Results 31 to 40 of about 4,593,278 (410)
Real-world analysis of leuprorelin acetate microspheres-based neoadjuvant therapy for patients with high-risk prostate cancer. [PDF]
Front OncolObjectiveBoennuokang® leuprorelin acetate microspheres show a certain efficacy in patients with prostate cancer, but its utilization as neoadjuvant therapy in patients with high-risk prostate cancer remains unclear.
Fu C +5 more
europepmc +2 more sources
Frontiers in Immunology, 2023 ObjectivesRecent clinical studies have demonstrated that immunotherapy-based neoadjuvant therapy have promising effectiveness for patients with resectable non-small cell lung cancer (NSCLC) in terms of pathologic response.
Jie Shen +5 more
doaj +1 more source
JAMA Oncology, 2021 Importance Total neoadjuvant therapy (TNT) is often used to downstage locally advanced rectal cancer (LARC) and decrease locoregional relapse; however, more than one-third of patients develop recurrent metastatic disease.
O. Rahma +22 more
semanticscholar +1 more source
Therapeutic Advances in Medical Oncology, 2020 Objective: Neoadjuvant chemotherapy has increased the survival benefit of non-small cell lung cancer (NSCLC) patients. The effects of different neoadjuvant therapies are still controversial. We carried out the study to evaluate the efficacy and safety of
Yijiu Ren +6 more
doaj +1 more source
Design of phase III trials with long-term survival outcomes based on short-term binary results [PDF]
Statistics in Medicine, 2021, 2020 Pathologic complete response (pCR) is a common primary endpoint for a phase II trial or even accelerated approval of neoadjuvant cancer therapy. If granted, a two-arm confirmatory trial is often required to demonstrate the efficacy with a time-to-event outcome such as overall survival.
arxiv +1 more source
Frontiers in Pharmacology, 2022 Background: Significant survival benefit of adjuvant imatinib therapy has been observed in gastrointestinal stromal tumor (GIST). However, the impact of neoadjuvant imatinib on prognosis of GIST remains unclear.
Zhen Liu +8 more
doaj +1 more source
Management of inoperable endometrial cancer [PDF]
Obstetrics & Gynecology Science, 2022 Some endometrial cancer (EMC) patients are not good candidates for primary surgery. The three major types of treatment for inoperable EMC are radiation therapy, chemotherapy, or their combination as neoadjuvant treatment before surgery. Radiation therapy
Supakorn Pitakkarnkul +2 more
doaj +1 more source
Neoadjuvant therapy alters the immune microenvironment in pancreatic cancer
Frontiers in Immunology, 2022 Pancreatic cancer has an exclusive inhibitory tumor microenvironment characterized by a dense mechanical barrier, profound infiltration of immunosuppressive cells, and a lack of penetration of effector T cells, which constitute an important cause for ...
Huiru Zhang +4 more
semanticscholar +1 more source
A study on the impact of neoadjuvant therapy on molecular subtype conversion in breast cancer. [PDF]
World J Surg OncolPurpose The aim of this study was to examine molecular subtype conversions in patients who received neoadjuvant therapy. Methods and materials A retrospective analysis was performed on 316 patients who underwent neoadjuvant therapy at Zhongnan Hospital ...
Zhang RZ +6 more
europepmc +2 more sources
Neoadjuvant therapy induces a potent immune response to sarcoma, dominated by myeloid and B cells.
Clinical Cancer Research, 2022 PURPOSE To characterize changes in the soft tissue sarcoma tumor immune microenvironment induced by standard neoadjuvant therapy with the goal of informing neoadjuvant immunotherapy trial design.
P. Goff +28 more
semanticscholar +1 more source