Results 71 to 80 of about 2,703,409 (308)

Neoadjuvant therapy for pancreatic cancer

British Journal of Surgery, 2007
No good evidence of benefit—trials ...
J, Kleeff, H, Friess, M W, Büchler
openaire   +2 more sources

Neoadjuvant versus Concurrent Androgen Deprivation Therapy in Localized Prostate Cancer Treated with Radiotherapy: A Systematic Review of the Literature

, 2023
Background: There is an ongoing debate on the optimal sequencing of androgen deprivation therapy (ADT) and radiotherapy (RT) in patients with localized prostate cancer (PCa). Recent data favors concurrent ADT and RT over the neoadjuvant approach. Methods:
Rodrigo Cartes, Boris Bahoric, Tamim Niazi, Steven Tisseverasinghe, Victor McPherson, Muneeb Uddin Karim, Stephan Probst, Alexis Rompré-Brodeur, Maurice Anidjar, Marwan Tolba   +9 more
core   +1 more source

Multitask Deep Learning Model for Predicting Lymph Node Metastasis and Disease‐Free Survival From Cytology Images in Bladder Cancer: A Multicenter Study With Pan‐Cytology Validation

Advanced Science, EarlyView.
Through self‐supervised pretraining and supervised fine‐tuning on large‐scale cytology image datasets, CytoNet predicts lymph node metastasis and survival. Across independent cohorts, this multitask framework demonstrates robust performance, improves risk stratification beyond radiological assessment, and provides interpretable evidence to support ...
Guibin Hong, Fan Jiang, Ye Xie, Xiaowei Huang, Runnan Shen, Yun Wang, Mengyi Zhu, Haoxuan Wang, Hongkun Yang, Yanxiao Nie, Zhen Lin, Rui Chen, Nengtai Ouyang, Tianxin Lin, Shaoxu Wu   +14 more
wiley   +1 more source

Neoadjuvant Therapy [PDF]

Advances in Surgery, 2020
Kristin N. Kelly, Francisco I. Macedo, Nipun B. Merchant   +2 more
openaire   +2 more sources

Advances for achieving a pathological complete response for rectal cancer after neoadjuvant therapy

Chronic Diseases and Translational Medicine, 2016
Neoadjuvant therapy has become the standard of care for locally advanced mid-low rectal cancer. Pathological complete response (pCR) can be achieved in 12%–38% of patients. Patients with pCR have the most favorable long-term outcomes.
Jian Cui, Hui Fang, Lin Zhang, Yun-Long Wu, Hai-Zeng Zhang   +4 more
doaj   +1 more source

Percentage methylation frequency and neoadjuvant therapy.

, 2012
The % methylation in tumors with neoadjuvant therapy (n = 9−2 luminal; 4 basal-like and 3 triple-negative cases) and without (n = 53; Mann-Whitney). There were 3 cases for which neoadjuvant therapy data was not available.
Bernard Kwabi-Addo (45546), Atsushi Terunuma (160968), Tiffany H. Dorsey (160966), Songping Wang (160963), Rick A. Kittles (160971), Stefan Ambs (37080)   +5 more
core   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Role for Neoadjuvant Systemic Therapy for Potentially Resectable Pancreatic Cancer

, 2023
Despite aggressive adjuvant management, a high percentage of patients who undergo appropriate surgical resection for pancreatic cancer will see their cancer recur and thus will not be cured. An important paradigm shift to achieve better outcomes has been
Brandon G. Smaglo
core   +1 more source

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source