Results 91 to 100 of about 2,507,641 (307)
Advanced Science, EarlyView.This study develops a multi‐dimensional vision Transformer‐based model, GAVR, to accurately distinguish gastric cancer T4a/b stages preoperatively. Validated across multi‐center cohorts, it achieves excellent performance and significantly improves radiologists’ diagnostic accuracy, offering a promising tool for clinical decision‐making.
Guoliang Zheng +20 more
wiley +1 more source
, 2022 (1) Background: Neoadjuvant therapy is the main therapeutic strategy for human epidermal growth factor receptor 2 (HER2)-positive breast cancer patients, and the combination of trastuzumab and pertuzumab (HP) has become a routine treatment.
Jingming Ye +10 more
core +1 more source
“To Anticipate”: Neoadjuvant Therapy in Melanoma with a Focus on Predictive Biomarkers [PDF]
, 2020 Despite surgical resection and adjuvant therapies, stage III melanomas still have a substantial risk of relapse. Neoadjuvant therapy is an emerging strategy that might offer superior efficacy compared to adjuvant therapy.
Ernesto Rossi +23 more
core +1 more source
Advanced Science, EarlyView.Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao +11 more
wiley +1 more source
Advanced Science, EarlyView.In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen +8 more
wiley +1 more source
NEOADJUVANT ENDOCRINE THERAPY FOR PATIENTS WITH ESTROGEN-RECEPTOR-POSITIVE BREAST CANCER
Сибирский онкологический журнал, 2018 More than 70 % of patients with breast cancer have estrogen-receptor-positive tumors (ER+) and are considered hormone- sensitive. That is why a vast majority of patients with early operable tumors receive adjuvant endocrine therapy.
V. F. Semiglazov +13 more
doaj +1 more source
Neoadjuvant Therapy in Colon Cancer [PDF]
Neoadjuvant therapy in colon cancer, traditionally reserved for rectal cancer, is gaining traction as a promising treatment strategy. This chapter offers a concise overview of neoadjuvant therapy in colon cancer, highlighting its evolving role, benefits,
Beets, Geerard L.
core +1 more source
Advanced Science, EarlyView.Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger +8 more
wiley +1 more source
World Journal of Surgical OncologyBackground For locally advanced gastric cancer (LAGC), neoadjuvant therapy prior to radical gastrectomy has been widely used. However, the treatment cycle and factors affecting the efficacy of neoadjuvant therapy are still unclear.
Zhihua Ren +6 more
doaj +1 more source
Advanced Science, EarlyView.Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang +9 more
wiley +1 more source