Results 171 to 180 of about 25,910 (264)

Dedifferentiation in endometrial cancer is associated with HLA‐I silencing that may be restored by IFN‐γ

The Journal of Pathology, Volume 270, Issue 3, Page 317-327, November 2026.
Abstract Dedifferentiated endometrial carcinoma occurs when a prognostically favorable low‐grade endometrial carcinoma transforms into a highly aggressive undifferentiated carcinoma following genomic inactivation of core SWItch/Sucrose Non‐Fermentable (SWI/SNF) complex protein(s).
Antonio De Leo, Madison Wickenberg, Marco Grillini, Camelia Alexandra Coadǎ, Pooja Praveen Kumar, Annie Tong, James Key, Hannah Kim, Felix Kommoss, Mark Carey, Yangxin Fu, Claudio Ceccarelli, Giovanni Tallini, Paul LaPointe, Martin Köbel, Cheng‐Han Lee   +15 more
wiley   +1 more source

Engineering T cell-engaging bispecific antibodies targeting KRAS G12V neoantigen across HLA-A*11:01 and HLA-A*03:01. [PDF]

J Immunother Cancer
Wu X, Effenberger C, Matsushita Y, Tanaka H, Ishii Y, Re S, Matsumoto S, Nagayama S, Nakamura Y, Kiyotani K.   +9 more
europepmc   +1 more source

Integrating Machine Learning to Identify Prognostic Subtypes and the Cisplatin Resistance Gene RRM2 in Lung Adenocarcinoma

Thoracic Cancer, Volume 17, Issue 21, November 2026.
Integrative multi‐omics clustering identified two molecular subtypes of lung adenocarcinoma (LUAD), and a 19‐gene consensus machine learning‐derived signature (CMLS) stratified patients by prognosis and immunotherapy response. Low‐CMLS tumors showed favorable survival, enhanced CD4 + T‐cell infiltration, higher TMB/TNB, and an immune‐hot phenotype ...
Huirong Huang, Ting Tao, Zhenqing Li, Kerong Zhai, Baiqiang Cui, Haiming Feng, Peiqiang Li, Bin Li   +7 more
wiley   +1 more source

AI-driven genotype-phenotype modeling: a framework integrating multi-modal single-cell genomics and reverse vaccinology for <i>de novo</i> design of multi-epitope cancer vaccines. [PDF]

Front Genet
Mallik M, Mollick SA.
europepmc   +1 more source

Nonlinear Aging of the Human TCR Repertoire Is Influenced by Sex, CMV, and Cancer

Aging Cell, Volume 25, Issue 11, November 2026.
Aging is associated with a nonlinear decline in peripheral blood TCR repertoire diversity, with an accelerated decline after ~50 years, while sex, CMV infection, and cancer further shape TCR diversity. The age‐associated decrease in diversity was accompanied by shifts in clonal and T cell subtype composition.
Naja Lange, Asbjørn K. Attermann, Randi Istrup Juul, Laura Andersen, Iver Nordentoft, Leon Eyrich Jessen, Nicholas McGranahan, Hugo J. W. L. Aerts, Lars Dyrskjøt, Nicolai J. Birkbak   +9 more
wiley   +1 more source

Developing neoantigen cancer vaccines: where are we now? [PDF]

Nat Commun
Markosyan N, Vonderheide RH.
europepmc   +1 more source

Extracellular Vesicles in Dermatology: Where Are We and What Lies Ahead?

Experimental Dermatology, Volume 35, Issue 11, November 2026.
ABSTRACT Extracellular vesicles (EVs) have emerged as key players in skin biology, mediating intercellular communication across diverse physiological and pathological contexts. In this review, we critically assess the current understanding of EVs in dermatology, highlighting their roles in skin homeostasis, ageing, inflammation, wound healing and ...
Ines Martic, Alessandro Paolini, Stefania Paola Bruno, Andrea Gallego, Dorottya Ádám, Sedat Odabas, Şebnem Erçelen Ceylan, Emanuela Camera, Paloma Pérez, Attila Oláh, Andrea Masotti, Mirjana Nacka‐Aleksić, Danuta Gutowska‐Owsiak, Nsrein Ali, Maria Cavinato   +14 more
wiley   +1 more source

Neoantigen Peptide [PDF]

, 2020
openaire   +1 more source

An Australian Narrative Review of Adoptive Cellular Therapies in Malignancy: Expanding Indications, Referral Pathways and Safety Beyond Specialist Centres

Medical Journal of Australia, Volume 224, Issue 11, November 2026.
ABSTRACT Adoptive cellular therapies (ACT), including tumour‐infiltrating lymphocyte (TIL), T‐cell receptor‐engineered T (TCR‐T) cell and chimeric antigen receptor T‐cell (CAR‐T) therapies, represent an evolving class of immunotherapies with established efficacy in selected haematological malignancies and emerging applications in solid tumours ...
Sarah Childs, David Ma, Anthony Rodrigues, Jennifer Massey, Rasha Cosman, Venessa Chin, Laila Girgis, James Lynam, Peter Lau, Barbara Withers, Anthony M. Joshua, Ben Tran, Jayesh Desai, Simon J. Harrison, John Moore, Jia Liu   +15 more
wiley   +1 more source

Autoimmunity: the neoantigen hypothesis

Frontiers in Immunology
Tomas Mustelin, Felipe Andrade
openaire   +3 more sources