Results 171 to 180 of about 30,793 (265)

Targeting splicing-derived neoantigens for precision cancer immunotherapy. [PDF]

Front Immunol
Tang M, Grimes HL, Salomonis N.
europepmc   +1 more source

Atherosclerosis: From Pathogenesis to Therapeutic Interventions

MedComm, Volume 7, Issue 11, November 2026.
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou, Chenxi Zhan, Yuting Li, Yi Zeng, Renfei Luo, Xin Ouyang, Shixing Liu, Renqiang Yang, Nianlong Yan, Long Jiang   +9 more
wiley   +1 more source

Harnessing Tumor-Specific Transcript Diversity Uncovers a Shared Neoantigen Reservoir for Pancreatic Ductal Adenocarcinoma. [PDF]

MedComm (2020)
Zhao J, Li Q, Lin P, Yang Y, Yu H, Wen Y, Yu W, He H, Tao S, Zhang F, Li Y, Hu Z, Xie J, Chen Z, Huang S.   +14 more
europepmc   +1 more source

Dedifferentiation in endometrial cancer is associated with HLA‐I silencing that may be restored by IFN‐γ

The Journal of Pathology, Volume 270, Issue 3, Page 317-327, November 2026.
Abstract Dedifferentiated endometrial carcinoma occurs when a prognostically favorable low‐grade endometrial carcinoma transforms into a highly aggressive undifferentiated carcinoma following genomic inactivation of core SWItch/Sucrose Non‐Fermentable (SWI/SNF) complex protein(s).
Antonio De Leo, Madison Wickenberg, Marco Grillini, Camelia Alexandra Coadǎ, Pooja Praveen Kumar, Annie Tong, James Key, Hannah Kim, Felix Kommoss, Mark Carey, Yangxin Fu, Claudio Ceccarelli, Giovanni Tallini, Paul LaPointe, Martin Köbel, Cheng‐Han Lee   +15 more
wiley   +1 more source

The Central Role of HLA Class II-Restricted Helper Neoantigen Vaccines in Cancer Immunotherapy. [PDF]

Cancers (Basel)
Morisaki T, Morisaki T.
europepmc   +1 more source

Integrating Machine Learning to Identify Prognostic Subtypes and the Cisplatin Resistance Gene RRM2 in Lung Adenocarcinoma

Thoracic Cancer, Volume 17, Issue 21, November 2026.
Integrative multi‐omics clustering identified two molecular subtypes of lung adenocarcinoma (LUAD), and a 19‐gene consensus machine learning‐derived signature (CMLS) stratified patients by prognosis and immunotherapy response. Low‐CMLS tumors showed favorable survival, enhanced CD4 + T‐cell infiltration, higher TMB/TNB, and an immune‐hot phenotype ...
Huirong Huang, Ting Tao, Zhenqing Li, Kerong Zhai, Baiqiang Cui, Haiming Feng, Peiqiang Li, Bin Li   +7 more
wiley   +1 more source

Beyond Canonical Neoantigens: Emerging Technologies for Identification of Noncanonical Antigens and Implications for Personalized Cancer Vaccines. [PDF]

Cancers (Basel)
Yang Y, Kane T, Abdelzaher AT, Goedegebuure SP, Gillanders WE.   +4 more
europepmc   +1 more source

Nonlinear Aging of the Human TCR Repertoire Is Influenced by Sex, CMV, and Cancer

Aging Cell, Volume 25, Issue 11, November 2026.
Aging is associated with a nonlinear decline in peripheral blood TCR repertoire diversity, with an accelerated decline after ~50 years, while sex, CMV infection, and cancer further shape TCR diversity. The age‐associated decrease in diversity was accompanied by shifts in clonal and T cell subtype composition.
Naja Lange, Asbjørn K. Attermann, Randi Istrup Juul, Laura Andersen, Iver Nordentoft, Leon Eyrich Jessen, Nicholas McGranahan, Hugo J. W. L. Aerts, Lars Dyrskjøt, Nicolai J. Birkbak   +9 more
wiley   +1 more source

AI-driven genotype-phenotype modeling: a framework integrating multi-modal single-cell genomics and reverse vaccinology for <i>de novo</i> design of multi-epitope cancer vaccines. [PDF]

Front Genet
Mallik M, Mollick SA.
europepmc   +1 more source

Extracellular Vesicles in Dermatology: Where Are We and What Lies Ahead?

Experimental Dermatology, Volume 35, Issue 11, November 2026.
ABSTRACT Extracellular vesicles (EVs) have emerged as key players in skin biology, mediating intercellular communication across diverse physiological and pathological contexts. In this review, we critically assess the current understanding of EVs in dermatology, highlighting their roles in skin homeostasis, ageing, inflammation, wound healing and ...
Ines Martic, Alessandro Paolini, Stefania Paola Bruno, Andrea Gallego, Dorottya Ádám, Sedat Odabas, Şebnem Erçelen Ceylan, Emanuela Camera, Paloma Pérez, Attila Oláh, Andrea Masotti, Mirjana Nacka‐Aleksić, Danuta Gutowska‐Owsiak, Nsrein Ali, Maria Cavinato   +14 more
wiley   +1 more source