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Adoptive cell therapy for cancer treatment [PDF]

Exploration, 2023
Adoptive cell therapy (ACT) is a rapidly growing anti‐cancer strategy that has shown promise in treating various cancer types. The concept of ACT involves activating patients’ own immune cells ex vivo and then transferring them back to the patients to ...
Shi Du, Jingyue Yan, Yonger Xue, Yichen Zhong, Yizhou Dong   +4 more
doaj   +4 more sources

Adoptive T cell therapy: Addressing challenges in cancer immunotherapy [PDF]

Journal of Translational Medicine, 2005
Adoptive T cell therapy involves the ex vivo selection and expansion of effector cells for the treatment of patients with cancer. In this review, the advantages and limitations of using antigen-specific T cells are discussed in counterpoint to vaccine ...
Yee Cassian
doaj   +3 more sources

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer [PDF]

Journal of Translational Medicine, 2012
A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly.
Stroncek David F, Berger Carolina, Cheever Martin A, Childs Richard W, Dudley Mark E, Flynn Peter, Gattinoni Luca, Heath James R, Kalos Michael, Marincola Francesco M, Miller Jeffrey S, Mostoslavsky Gustavo, Powell Daniel J, Rao Mahendra, Restifo Nicholas P, Rosenberg Steven A, O'Shea John, Melief Cornelis JM   +17 more
doaj   +6 more sources

Adoptive Cell Therapy for T-Cell Malignancies. [PDF]

Cancers (Basel), 2022
T-cell malignancies are often aggressive and associated with poor prognoses. Adoptive cell therapy has recently shown promise as a new line of therapy for patients with hematological malignancies. However, there are currently challenges in applying adoptive cell therapy to T-cell malignancies.
Fang KK, Lee JB, Zhang L.
europepmc   +3 more sources

ADOPTIVE CELL THERAPY: CURRENT ADVANCES

Южно-Российский онкологический журнал, 2020
The immune system plays an important role in the development and treatment of many cancer types. This fact determined the emergence of numerous immunotherapeutic approaches, including that of adoptive cell therapy (ACT).
T. V. Shamova, A. O. Sitkovskaya, L. N. Vashchenko, E. E. Kechedzhieva   +3 more
doaj   +3 more sources

Challenges and new technologies in adoptive cell therapy [PDF]

Journal of Hematology & Oncology, 2023
Adoptive cell therapies (ACTs) have existed for decades. From the initial infusion of tumor-infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and chimeric antigen receptor (CAR)-T cell therapies, many novel strategies ...
Pengchao Zhang, Guizhong Zhang, Xiaochun Wan   +2 more
doaj   +2 more sources

Adoptive Cell Therapy for Patients with Melanoma [PDF]

Journal of Cancer, 2011
Adoptive cell therapy can be an effective treatment for some patients with advanced cancer. This report summarizes clinical trial results from the Surgery Branch, NCI, investigating tumor infiltrating lymphocytes (TIL) and gene engineered peripheral ...
Mark E. Dudley
doaj   +3 more sources

Application of adoptive cell therapy in malignant melanoma [PDF]

Journal of Translational Medicine
Cutaneous melanoma is one of the most aggressive skin cancers originating from skin pigment cells. Patients with advanced melanoma suffer a poor prognosis and generally cannot benefit well from surgical resection and chemo/target therapy due to ...
Qianrong Hu, Jiangying Xuan, Lu Wang, Kangjie Shen, Zixu Gao, Yuhong Zhou, Chuanyuan Wei, Jianying Gu   +7 more
doaj   +2 more sources

Adoptive T-cell therapy for malignant disorders

Haematologica, 2008
Adoptive cell transfer (ACT) using ex vivo manipulated T lymphocytes has emerged as an important advance in cancer immunotherapy, allowing for re-education and re-setting of the host immune system. Recent technological advances, particularly the development of artificial antigen presenting cells (
Daniel J. Powell, Bruce L. Levine
doaj   +3 more sources

Adoptive immune cell therapy for colorectal cancer

Frontiers in Immunology
Colorectal cancer (CRC) is a major cause of cancer-related morbidity and mortality worldwide, with limited options for patients at advanced stages. Immunotherapy, particularly immune cell-based therapies, has gained significant attention as an innovative
Chenxiao Liu, Nan Liu, Nan Liu, Tongcun Zhang, Tongcun Zhang, Yanyang Tu, Yanyang Tu   +6 more
doaj   +3 more sources