Results 1 to 10 of about 58,854 (115)

Adoptive cell therapy for cancer treatment [PDF]

Exploration, 2023
Adoptive cell therapy (ACT) is a rapidly growing anti‐cancer strategy that has shown promise in treating various cancer types. The concept of ACT involves activating patients’ own immune cells ex vivo and then transferring them back to the patients to ...
Shi Du, Jingyue Yan, Yonger Xue, Yichen Zhong, Yizhou Dong   +4 more
doaj   +3 more sources

Advances in adoptive cell therapy for ovarian cancer [PDF]

Frontiers in Immunology
Ovarian cancer remains the most lethal gynecological malignancy worldwide, with late-stage diagnosis, high recurrence rates, and chemoresistance posing persistent clinical challenges.
Na Zhao, Yujiao An, Yujiao An, Shanwei Guo, Zhen Xu, Hongtang Shi, Zhentao Zhang   +6 more
doaj   +2 more sources

Cell-Type-Tailored Hydrogels for Adoptive Cell Therapy in Cancer [PDF]

Gels
Hydrogel-enabled adoptive cell therapy (ACT) offers a localized and controllable strategy for improving cellular immunotherapy in solid tumors.
Jin Hak Shin, Yeonju Song, Jeehun Park
doaj   +2 more sources

Application of adoptive cell therapy in malignant melanoma [PDF]

Journal of Translational Medicine
Cutaneous melanoma is one of the most aggressive skin cancers originating from skin pigment cells. Patients with advanced melanoma suffer a poor prognosis and generally cannot benefit well from surgical resection and chemo/target therapy due to ...
Qianrong Hu, Jiangying Xuan, Lu Wang, Kangjie Shen, Zixu Gao, Yuhong Zhou, Chuanyuan Wei, Jianying Gu   +7 more
doaj   +2 more sources

Genetically Modified T Cells for Esophageal Cancer Therapy: A Promising Clinical Application

Frontiers in Oncology, 2021
Esophageal cancer is an exceedingly aggressive and malignant cancer that imposes a substantial burden on patients and their families. It is usually treated with surgery, chemotherapy, radiotherapy, and molecular-targeted therapy. Immunotherapy is a novel
Yu-Ge Zhu, Bu-Fan Xiao, Jing-Tao Zhang, Xin-Run Cui, Zhe-Ming Lu, Nan Wu   +5 more
doaj   +1 more source

ADOPTIVE CELL THERAPY: CURRENT ADVANCES

Южно-Российский онкологический журнал, 2020
The immune system plays an important role in the development and treatment of many cancer types. This fact determined the emergence of numerous immunotherapeutic approaches, including that of adoptive cell therapy (ACT).
T. V. Shamova, A. O. Sitkovskaya, L. N. Vashchenko, E. E. Kechedzhieva   +3 more
doaj   +1 more source

Esophageal cancer responsive to the combination of immune cell therapy and low-dose nivolumab: two case reports

Journal of Medical Case Reports, 2021
Background Blocking the programmed death 1 pathway by immune checkpoint inhibitors induces dramatic antitumor activity in patients with malignant tumors. However, the clinical response to immune checkpoint inhibitors remains limited owing to the patients’
Rishu Takimoto, Takashi Kamigaki, Takuji Gotoda, Toshimi Takahashi, Sachiko Okada, Hiroshi Ibe, Eri Oguma, Shigenori Goto   +7 more
doaj   +1 more source

Optimization of culture media for ex vivo T-cell expansion for adoptive T-cell therapy

Advanced Biomedical Research, 2022
Background: Adoptive T-cell therapy is a promising treatment strategy for cancer immunotherapy. The ability of immunotherapy based on the adoptive cell transfer of genetically modified T cells to generate powerful clinical responses has been highlighted ...
Ilnaz Rahimmanesh, Mehrsa Tavangar, Seyedeh Noushin Zahedi, Yadollah Azizi, Hossein Khanahmad Shahreza   +4 more
doaj   +1 more source

Adoptive T cell therapy: Addressing challenges in cancer immunotherapy

Journal of Translational Medicine, 2005
Adoptive T cell therapy involves the ex vivo selection and expansion of effector cells for the treatment of patients with cancer. In this review, the advantages and limitations of using antigen-specific T cells are discussed in counterpoint to vaccine ...
Yee Cassian
doaj   +1 more source

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer

Journal of Translational Medicine, 2012
A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly.
Stroncek David F, Berger Carolina, Cheever Martin A, Childs Richard W, Dudley Mark E, Flynn Peter, Gattinoni Luca, Heath James R, Kalos Michael, Marincola Francesco M, Miller Jeffrey S, Mostoslavsky Gustavo, Powell Daniel J, Rao Mahendra, Restifo Nicholas P, Rosenberg Steven A, O'Shea John, Melief Cornelis JM   +17 more
doaj   +1 more source