Results 21 to 30 of about 7,389,456 (292)

Adoptive T cell therapy of cancer [PDF]

Current Opinion in Immunology, 2010
Adoptive transfer of T cells specific for antigens expressed on tumor cells is an attractive strategy for producing targeted and long-lived anti-tumor activity. T cell therapies have shown activity in selected clinical applications but broader application is limited by inadequate persistence of transferred T cells and by tumor-evasion strategies ...
Malcolm K, Brenner, Helen E, Heslop
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Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA–peptide tetramers [PDF]

, 2005
Stem cell transplantation is used widely in the management of a range of diseases of the hemopoietic system. Patients are immunosuppressed profoundly in the early posttransplant period, and reactivation of cytomegalovirus (CMV) remains a significant ...
Premini Mahendra, Craddock, Charles., McDonald, D, Billingham, Lucinda, Steward, Colin, Dorothy McDonald, Pourgheysari, Batoul, Eduardo Olavarria, Mahendra, Premini, Assenmacher, Mario., Olavarria, Eduardo, Tauro, Sudhir, Chakraverty, Ronjon., Goldman, John, Cobbold, Mark., Moss, Paul; id_orcid, Steward, Colin., McDonald, Dorothy, Pourgheysari Najafabadi, Batoul, John Goldman, Ronjon Chakraverty, Chakraverty, Ronjon, Crawley, Charles, Colin Steward, Billingham, Lucinda; id_orcid, Craddock, Charles; id_orcid, Assenmacher, Mario, Goldman, J, Pourgheysari, Batoul., Billingham, Lucinda., Tauro, S, Crawley, Charles., Charles Crawley, Osman, H, Batoul Pourgheysari, Naeem Khan, Mario Assenmacher, Osman, Husam, Assenmacher, M, Khan, Naeem, Goldman, John., Craddock, Charles, Mark Cobbold, Steward, C, McDonald, Dorothy., Olavarria, Eduardo., Olavarria, E, Husam Osman, Cobbold, Mark, Crawley, C, Osman, Husam., Mahendra, Premini., Sudhir Tauro, Tauro, Sudhir., Charles Craddock, Moss, Paul A. H., Moss, Paul A H, Khan, Naeem., Lucinda Billingham, Paul A.H. Moss, Moss, Paul A.H.   +60 more
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Advances in T Cell Receptor Design Strategies for Adoptive Cell Therapy

, 2022
Advances in T Cell Receptor Design Strategies for Adoptive Cell ...
Anthony J Bais (13285305)
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Safety switches for adoptive cell therapy

Current Opinion in Immunology, 2022
Adoptive transfer of allogeneic and genetically modified T cells, such as CAR-T and TCR-T cells, can induce profound immune reactivity against cancer tissue. At the same time, these therapies are associated with severe off-target and on-target toxicities.
Ali Can Sahillioglu, Ton N Schumacher
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Adoptive T-cell therapy for Leukemia [PDF]

Molecular and Cellular Therapies, 2014
Allogeneic stem cell transplantation (alloSCT) is the most robust form of adoptive cellular therapy (ACT) and has been tremendously effective in the treatment of leukemia. It is one of the original forms of cancer immunotherapy and illustrates that lymphocytes can specifically recognize and eliminate aberrant, malignant cells.
Garber, Haven R, Mirza, Asma, Mittendorf, Elizabeth A, Alatrash, Gheath   +3 more
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Local Irradiation Sensitized Tumors to Adoptive T Cell Therapy via Enhancing the Cross-Priming, Homing, and Cytotoxicity of Antigen-Specific CD8 T Cells

Frontiers in Immunology, 2019
The successful generation of T cell-mediated immunity for the treatment of cancer has been a major focal point of research. One of the critical strategies of cancer immunotherapy is to efficiently activate antigen-specific CD8 T cells in the ...
Jin-Zhi Lai, Jin-Zhi Lai, Yan-Yang Zhu, Mei Ruan, Ling Chen, Qiu-Yu Zhang   +5 more
doaj   +1 more source

Adoptive T-Cell Therapy for Cancer [PDF]

, 2016
Recent developments have demonstrated that immunotherapies are capable of achieving durable antitumor responses in patients with metastatic cancer. One modality that has been able to induce durable complete regressions in patients with melanoma has been adoptive cell therapy (ACT).
James C, Yang, Steven A, Rosenberg
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Immunodominance of lytic cycle antigens in Epstein-Barr virus-specific CD4+ T cell preparations for therapy. [PDF]

, 2007
Epstein-Barr virus (EBV) is associated with a number of human malignancies. EBV-positive post-transplant lymphoproliferative disease in solid organ and hematopoietic stem cell transplant recipients has been successfully treated by the adoptive transfer ...
Burdach, S., Witter, K., Boerschmann Heike, Boerschmann, H., Mautner, Josef, Georg W Bornkamm, Adhikary, D., Adhikary, Dinesh, Uta Behrends, Burdach Stefan, Bornkamm, G.W., Mautner, J., Georg W, Andrea Pfünder, Moosmann, A., Witter Klaus, Adhikary Dinesh, Pfünder, Andrea, Dinesh Adhikary, Klaus Witter, Pfünder Andrea, Josef Mautner, Behrends Uta, Stefan Burdach, Moosmann Andreas, Andreas Moosmann, Bornkamm Georg W., Behrends, Uta, Boerschmann, Heike, Burdach, Stefan, Bornkamm, Georg W., Pfünder, A., Witter, Klaus, Behrends, U., Mautner Josef, Moosmann, Andreas, Heike Boerschmann, Adhikary, D;Behrends, U;Boerschmann, H;Pfünder, A;Burdach, S;Moosmann, A;Witter, K;Bornkamm, GW;Mautner, J, Georg W. Bornkamm   +38 more
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Adoptive tumor infiltrating lymphocytes cell therapy for cervical cancer [PDF]

, 2022
Cervical cancer is one of the most common malignancies among females. As a virus-related cancer, cervical cancer has attracted a lot of attention to develop virus-targeted immune therapy, including vaccine and adoptive immune cell therapy (ACT). Adoptive
Wenjing Hu, Zhu, Yahui, Xie, Li, Liu, Baorui, Hu, Wenjing, Zhou, Jing, Lijing Zhu, Li Xie, Yahui Zhu, Zhu, Lijing, Baorui Liu, Jing Zhou   +11 more
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TCR-engineered adoptive cell therapy effectively treats intracranial murine glioblastoma [PDF]

, 2023
BACKGROUND: Adoptive cellular therapies with chimeric antigen receptor T cells have revolutionized the treatment of some malignancies but have shown limited efficacy in solid tumors such as glioblastoma and face a scarcity of safe therapeutic targets. As
Bowman-Kirigin, Jay A, White, Michael J, Schaettler, Maximilian O, Kobayashi, Dale K, Wang, Anthony Z, Bender, Diane E, Dunn, Gavin P, Livingstone, Alexandra J, Li, Mao, Liu, Connor J, Kranz, David M, Coxon, Andrew T, Desai, Rupen, Johanns, Tanner M, Michael J White, Mao Li, Tanner M Johanns, Alexandra J Livingstone, Dale K Kobayashi, David M Kranz, Rupen Desai, Jay A Bowman-Kirigin, Gavin P Dunn, Anthony Z Wang, Diane E Bender, Maximilian O Schaettler, Connor J Liu, Andrew T Coxon   +27 more
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