Results 21 to 30 of about 94,528 (347)

Safety switches for adoptive cell therapy

Current Opinion in Immunology, 2022
Adoptive transfer of allogeneic and genetically modified T cells, such as CAR-T and TCR-T cells, can induce profound immune reactivity against cancer tissue. At the same time, these therapies are associated with severe off-target and on-target toxicities.
Ali Can Sahillioglu, Ton N Schumacher
openaire   +2 more sources

T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells [PDF]

, 2013
Memory T cells are composed of effector, central, and memory stem cells. Previous studies have implicated that both T-bet and Eomes are involved in the generation of effector and central memory CD8 T cells.
A Banerjee, AC Mullen, AM Intlekofer, AM Intlekofer, AM Intlekofer, B Lu, Binfeng Lu, CS Hinrichs, EL Pearce, F Pages, F Sallusto, Gang Li, GM Lord, Hong-Rui Wang, HZ Qui, I Atreya, JT Chang, K Kato, L Gattinoni, L Gattinoni, LJ Chen, M Wiesel, MA Paley, ME Pipkin, Mehrdad Matloubian, N Takemoto, NP Restifo, NS Joshi, Qianting Yang, SJ Szabo, WW Overwijk, X Zhou, Xinchun Chen, Xueguang Zhang, Y Zhang, Y Zhu, Yibei Zhu   +36 more
core   +5 more sources

Adoptive T-cell therapy of cancer. [PDF]

Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 2009
Adoptive immunotherapy is determined as "the isolation of antigen-specific cells, their ex vivo expansion and activation, and subsequent autologous administration" and is a promising approach to inducing antitumour immune responses. Identification of tumour antigens and monitoring the persistence and transport of transferred cells has provided our ...
Ton N M, Schumacher, Nicholas P, Restifo
openaire   +6 more sources

Optimization of culture media for ex vivo T-cell expansion for adoptive T-cell therapy

Advanced Biomedical Research, 2022
Background: Adoptive T-cell therapy is a promising treatment strategy for cancer immunotherapy. The ability of immunotherapy based on the adoptive cell transfer of genetically modified T cells to generate powerful clinical responses has been highlighted ...
Ilnaz Rahimmanesh, Mehrsa Tavangar, Seyedeh Noushin Zahedi, Yadollah Azizi, Hossein Khanahmad Shahreza   +4 more
doaj   +1 more source

Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo [PDF]

, 2015
Objective: Gut homing of lymphocytes via adhesion molecules has recently emerged as new target for therapy in inflammatory bowel diseases. We aimed to analyze the in vivo homing of effector (Teff) and regulatory (Treg) T cells to the inflamed gut via ...
Agace, Alastair Watson, Anika Fischer, Atreya, Babyatsky, Baumgart, Canavan, Caroline Voskens, Christoph Becker, Clemens Neufert, Danese, Desreumaux, Dustin, Egawa, Fantini, Feagan, Fuss, Gerlach, Gerold Schuler, Ghosh, Haddad, Hamann, Hesterberg, Hoshino, Imke Atreya, Jovani, Kanai, Kempster, Kim, Ley, Li, Macdonald, Markus F Neurath, Matsuzaki, Maul, Neurath, Neurath, Nguyen, Nourshargh, Oki, Papadakis, Picarella, Podolsky, Pryde, Raja Atreya, Rocío López-Posadas, Rott, Rutgeerts, Sandborn, Sandborn, Sebastian Zundler, Shultz, Simon Hirschmann, Strober, Thomas, Tidswell, Timo Rath, Van Assche, Vermeire, Villablanca, Wang, Weninger, Wirtz, Wyant, Wyant   +64 more
core   +1 more source

Synthetic Antigen‐Presenting Cells for Adoptive T Cell Therapy [PDF]

Advanced Therapeutics, 2021
Abstract Adoptive T cell therapies are transforming the treatment of solid and liquid tumors, yet their widespread adoption is limited in part by the challenge of generating functional cells. T cell activation and expansion using conventional antigen‐presenting cells (APCs) is unreliable due to the variable quality of donor‐derived ...
Shreyas N. Dahotre, Anna M. Romanov, Fang-Yi Su, Gabriel A. Kwong   +3 more
openaire   +2 more sources

Immunotherapy of lung cancer: An update [PDF]

, 2006
In Germany lung cancer is the leading cause of cancer-associated death in men. Surgery, chemotherapy and radiation may enhance survival of patients suffering from lung cancer but the enhancement is typically transient and mostly absent with advanced ...
Aman MJ, Anthony HM, Atanackovic D, Bast RC, Bermers AJA, Carbone FR, Chan B, Cohen MH, Dickler M, Dranoff G, Dudley ME, Faradji A, Gotoh K, Grant SC, Kimura H, Kimura Y, Korkolopoulou P, Kradin RL, Krug LM, Krug LM, Liu M, Ma J, Marshall JL, Melioli G, Millar JW, Nemunaitis J, Nikitina E, O'Brien ME, Palmer M, Raez LE, Ratto GB, Salgia R, Smith A, Sterman D, Swisher S, Villalona-Calero MA, Yano T   +36 more
core   +1 more source

Adoptive T-cell therapy for Leukemia [PDF]

Molecular and Cellular Therapies, 2014
Allogeneic stem cell transplantation (alloSCT) is the most robust form of adoptive cellular therapy (ACT) and has been tremendously effective in the treatment of leukemia. It is one of the original forms of cancer immunotherapy and illustrates that lymphocytes can specifically recognize and eliminate aberrant, malignant cells.
Garber, Haven R, Mirza, Asma, Mittendorf, Elizabeth A, Alatrash, Gheath   +3 more
openaire   +2 more sources

Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity. [PDF]

, 2014
The majority of chimeric antigen receptor (CAR) T-cell research has focused on attacking cancer cells. Here, we show that targeting the tumor-promoting, nontransformed stromal cells using CAR T cells may offer several advantages.
Albelda, Steven M., Antzis, Michael, Cotner, Cody E., Durham, Amy C., Johnson, Laura A., June, Carl H., Kapoor, Veena, Lo, Albert, Majumdar, Rajrupa S., Puré, Ellen, Scholler, John, Solomides, MD, Charalambos C., Sun, Jing, Wang, Liang-Chuan S.   +13 more
core   +2 more sources

Biological therapy in the treatment of melanoma [PDF]

, 2018
Melanoma is one of the most aggressive tumors and its incidence is on the rise. The low rates of survival in metastatic melanoma has led to the development of new drugs for this type of patient, such as biological therapy which has shown remarkable ...
Benea, Vasile, Georgescu, Simona Roxana, Ghita, Ela, Ioghen, Mihaela Roxana, Ion, Alexandra-Florentina, Mitran, Cristina-Iulia, Mitran, Madalina-Irina, Sarbu, Maria Isabela, Tampa, Mircea   +8 more
core   +3 more sources