Results 11 to 20 of about 7,389,456 (292)

Adoptive Cell Therapy for Patients with Melanoma [PDF]

Journal of Cancer, 2011
Adoptive cell therapy can be an effective treatment for some patients with advanced cancer. This report summarizes clinical trial results from the Surgery Branch, NCI, investigating tumor infiltrating lymphocytes (TIL) and gene engineered peripheral ...
Mark E. Dudley
doaj   +4 more sources

Adoptive Cell Therapy for T-Cell Malignancies [PDF]

Cancers, 2022
T-cell malignancies are often aggressive and associated with poor prognoses. Adoptive cell therapy has recently shown promise as a new line of therapy for patients with hematological malignancies. However, there are currently challenges in applying adoptive cell therapy to T-cell malignancies.
Fang, Karen Kai-Lin, Lee, Jong Bok, Zhang, Li   +2 more
openaire   +3 more sources

Adoptive T-cell therapy of cancer. [PDF]

Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 2009
Adoptive immunotherapy is determined as "the isolation of antigen-specific cells, their ex vivo expansion and activation, and subsequent autologous administration" and is a promising approach to inducing antitumour immune responses. Identification of tumour antigens and monitoring the persistence and transport of transferred cells has provided our ...
Ton N M, Schumacher, Nicholas P, Restifo
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Adoptive B cell therapy for chronic viral infection [PDF]

Frontiers in Immunology, 2022
T cell-based therapies have been widely explored for the treatment of cancer and chronic infection, but B cell-based therapies have remained largely unexplored.
Young Rock Chung, Tanushree Dangi, Nicole Palacio, Sarah Sanchez, Pablo Penaloza-MacMaster   +4 more
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Remolding the tumor microenvironment by bacteria augments adoptive T cell therapy in advanced-stage solid tumors

Signal Transduction and Targeted Therapy
The intricate tumor microenvironment presents formidable obstacles to the efficacy of adoptive T cell therapy in the management of solid tumors by limiting the infiltration and inducing exhaustion of the transferred T cells.
Chaojie Zhu, Chao Liu, Qing Wu, Tao Sheng, Ruyi Zhou, En Ren, Ruizhe Zhang, Zhengjie Zhao, Jiaqi Shi, Xinyuan Shen, Zhongquan Sun, Zhengwei Mao, Kaixin He, Lingxiao Zhang, Yuan Ding, Zhen Gu, Weilin Wang, Hongjun Li   +17 more
doaj   +2 more sources

Enhanced cellular therapy: revolutionizing adoptive cellular therapy

Experimental Hematology & Oncology
Enhanced cellular therapy has emerged as a novel concept following the basis of cellular therapy. This treatment modality applied drugs or biotechnology to directly enhance or genetically modify cells to enhance the efficacy of adoptive cellular therapy (
Meng-Yao Xu, Na Zeng, Chen-Qian Liu, Jian-Xuan Sun, Ye An, Si-Han Zhang, Jin-Zhou Xu, Xing-Yu Zhong, Si-Yang Ma, Hao-Dong He, Jia Hu, Qi-Dong Xia, Shao-Gang Wang   +12 more
doaj   +2 more sources

Advances in Adoptive T-cell Therapy for Metastatic Melanoma

, 2023
Adoptive T cell therapy (ACT) is a fast developing, niche area of immunotherapy (IO), which is revolutionising the therapeutic landscape of solid tumour oncology, especially metastatic melanoma (MM). Identifying tumour antigens (TAs) as potential targets,
Elisabet Sanchez, Rassy, Elie, Elie Rassy, Stergios Boussios, Sanchez, Elisabet, Aruni Ghose, Das, Aparimita, Chargari, Cyrus, Cyrus Chargari, Aparimita Das, Ghose, Aruni, Naicker, Kevin, Kevin Naicker, Boussios, Stergios, Boussios, S.   +14 more
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Adoptive Cell Therapies for Glioblastoma [PDF]

Frontiers in Oncology, 2013
Glioblastoma (GBM) is the most common and most aggressive primary brain malignancy and, as it stands, is virtually incurable. With the current standard of care, maximum feasible surgical resection followed by radical radiotherapy and adjuvant temozolomide, survival rates are at a median of 14.6 months from diagnosis in molecularly unselected patients ...
Kevin James Bielamowicz, Kevin James Bielamowicz, Kevin James Bielamowicz, Kevin James Bielamowicz, Shumaila eKhawja, Nabil eAhmed, Nabil eAhmed, Nabil eAhmed, Nabil eAhmed   +8 more
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Adoptive Cell Transfer Therapy [PDF]

Seminars in Oncology, 2007
Adoptive cell transfer therapy has developed into a potent and effective treatment for patients with metastatic melanoma. Current application of this therapy relies on the ex vivo generation of highly active, highly avid tumor-reactive lymphocyte cultures from endogenous tumor infiltrating lymphocytes or on the genetic engineering of cells using ...
Mark E, Dudley, Steven A, Rosenberg
openaire   +2 more sources

Adoptive Cell Therapy for Sarcoma [PDF]

Immunotherapy, 2015
Current therapy for sarcomas, though effective in treating local disease, is often ineffective for patients with recurrent or metastatic disease. To improve outcomes, novel approaches are needed and cell therapy has the potential to meet this need since it does not rely on the cytotoxic mechanisms of conventional therapies.
Melinda, Mata, Stephen, Gottschalk
openaire   +2 more sources