Results 11 to 20 of about 56,610 (260)
Adoptive Cell Therapy for Patients with Melanoma [PDF]
Journal of Cancer, 2011 Adoptive cell therapy can be an effective treatment for some patients with advanced cancer. This report summarizes clinical trial results from the Surgery Branch, NCI, investigating tumor infiltrating lymphocytes (TIL) and gene engineered peripheral ...
Mark E. Dudley
doaj +3 more sources
Adoptive Cell Transfer Therapy [PDF]
Seminars in Oncology, 2007 Adoptive cell transfer therapy has developed into a potent and effective treatment for patients with metastatic melanoma. Current application of this therapy relies on the ex vivo generation of highly active, highly avid tumor-reactive lymphocyte cultures from endogenous tumor infiltrating lymphocytes or on the genetic engineering of cells using ...
Mark E, Dudley, Steven A, Rosenberg
openaire +2 more sources
Adoptive Cell Therapy for Sarcoma [PDF]
Immunotherapy, 2015 Current therapy for sarcomas, though effective in treating local disease, is often ineffective for patients with recurrent or metastatic disease. To improve outcomes, novel approaches are needed and cell therapy has the potential to meet this need since it does not rely on the cytotoxic mechanisms of conventional therapies.
Melinda, Mata, Stephen, Gottschalk
openaire +2 more sources
Adoptive Cell Therapies for Glioblastoma [PDF]
Frontiers in Oncology, 2013 Glioblastoma (GBM) is the most common and most aggressive primary brain malignancy and, as it stands, is virtually incurable. With the current standard of care, maximum feasible surgical resection followed by radical radiotherapy and adjuvant temozolomide, survival rates are at a median of 14.6 months from diagnosis in molecularly unselected patients ...
Kevin James Bielamowicz +8 more
openaire +3 more sources
Adoptive Cell Therapy for T-Cell Malignancies
Cancers, 2022 T-cell malignancies are often aggressive and associated with poor prognoses. Adoptive cell therapy has recently shown promise as a new line of therapy for patients with hematological malignancies. However, there are currently challenges in applying adoptive cell therapy to T-cell malignancies.
Fang, Karen Kai-Lin +2 more
openaire +2 more sources
Adoptive T cell therapy of cancer [PDF]
Current Opinion in Immunology, 2010 Adoptive transfer of T cells specific for antigens expressed on tumor cells is an attractive strategy for producing targeted and long-lived anti-tumor activity. T cell therapies have shown activity in selected clinical applications but broader application is limited by inadequate persistence of transferred T cells and by tumor-evasion strategies ...
Malcolm K, Brenner, Helen E, Heslop
openaire +2 more sources
Safety switches for adoptive cell therapy
Current Opinion in Immunology, 2022 Adoptive transfer of allogeneic and genetically modified T cells, such as CAR-T and TCR-T cells, can induce profound immune reactivity against cancer tissue. At the same time, these therapies are associated with severe off-target and on-target toxicities.
Ali Can Sahillioglu, Ton N Schumacher
openaire +2 more sources
Adoptive T-cell therapy of cancer. [PDF]
Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 2009 Adoptive immunotherapy is determined as "the isolation of antigen-specific cells, their ex vivo expansion and activation, and subsequent autologous administration" and is a promising approach to inducing antitumour immune responses. Identification of tumour antigens and monitoring the persistence and transport of transferred cells has provided our ...
Ton N M, Schumacher, Nicholas P, Restifo
openaire +6 more sources
Adoptive T-cell therapy for Leukemia [PDF]
Molecular and Cellular Therapies, 2014 Allogeneic stem cell transplantation (alloSCT) is the most robust form of adoptive cellular therapy (ACT) and has been tremendously effective in the treatment of leukemia. It is one of the original forms of cancer immunotherapy and illustrates that lymphocytes can specifically recognize and eliminate aberrant, malignant cells.
Garber, Haven R +3 more
openaire +2 more sources
New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer
Journal of Translational Medicine, 2012 A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly.
Stroncek David F +17 more
doaj +1 more source