Results 221 to 230 of about 30,793 (265)

Engineering editopes through programmable RNA editing toward tumor neoantigen generation. [PDF]

EMBO J
Pecori R, Casati B, Merdler-Rabinowicz R, Landesman N, Sanghvi K, Zens S, Bilgin E, Topouzi M, Kipfstuhl K, Pinamonti V, Arnold A, Abukhalaf M, Gomez-Zepeda D, Tenzer S, Lindner JM, Platten M, Offringa R, Carretero R, Ruppin E, Levanon EY, Papavasiliou FN.   +20 more
europepmc   +1 more source

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Cancer Neoantigens

Annual Review of Immunology, 2019
Malignant transformation of cells depends on accumulation of DNA damage. Over the past years we have learned that the T cell–based immune system frequently responds to the neoantigens that arise as a consequence of this DNA damage. Furthermore, recognition of neoantigens appears an important driver of the clinical activity of both T cell checkpoint ...
Pia Kvistborg, Ton Schumacher, Wouter Scheper   +2 more
exaly   +3 more sources

Clonal Neoantigens Elicit T Cell Immunoreactivity and Sensitivity to Immune Checkpoint Blockade [PDF]

Science, 2016
As tumors grow, they acquire mutations, some of which create neoantigens that influence the response of patients to immune checkpoint inhibitors. We explored the impact of neoantigen intratumor heterogeneity (ITH) on antitumor immunity.
Jedd D. Wolchok, Thomas B K Watkins, Vladimir Makarov   +2 more
exaly   +2 more sources

Antigen Presentation Profiling Reveals Recognition of Lymphoma Immunoglobulin Neoantigens [PDF]

Nature, 2017
Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. However, the personalized identification and validation of neoantigens remains a major challenge.
Lisa E Wagar, Michael Green, Mark M. Davis   +2 more
exaly   +2 more sources

Neoantigens in cancer immunotherapy

Science, 2015
The clinical relevance of T cells in the control of a diverse set of human cancers is now beyond doubt. However, the nature of the antigens that allow the immune system to distinguish cancer cells from noncancer cells has long remained obscure. Recent technological innovations have made it possible to dissect the immune response to patient-specific ...
Ton N, Schumacher, Robert D, Schreiber
openaire   +2 more sources

Neoantigens in osteoarthritic cartilage

Current Opinion in Rheumatology, 2004
Osteoarthritis has been considered a degenerative disease. However, recent evidence supports involvement of immunologic mechanisms in this pathophysiology: for example, inflammation of synovial tissue is observed in osteoarthritis. In osteoarthritis, the proinflammatory cytokine interleukin-1, which is produced by activated synoviocytes and mononuclear
Tomohiro, Kato, Yang, Xiang, Hiroshi, Nakamura, Kusuki, Nishioka   +3 more
openaire   +2 more sources

Neoantigens Associated with Halothane Hepatitis

Drug Metabolism Reviews, 1989
(1989). Neoantigens Associated with Halothane Hepatitis. Drug Metabolism Reviews: Vol. 20, No. 2-4, pp. 203-217.
L R, Pohl, J G, Kenna, H, Satoh, D, Christ, J L, Martin   +4 more
openaire   +2 more sources

Mechanism of neoantigen generation and advances in neoantigen-based immunotherapies in colorectal cancer

Medical Oncology
Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality worldwide. Conventional therapeutic modalities-such as surgery, chemotherapy, and radiotherapy-yield suboptimal outcomes in advanced or recurrent disease, while immune checkpoint inhibitors demonstrate durable clinical benefit almost exclusively in the microsatellite ...
Na, Wang, Yimeng, Xia, Ping, Wang, Yijia, He, Kun, Zhao, Zhe, Zhang   +5 more
openaire   +2 more sources