Neoblast Specialization in Regeneration of the Planarian Schmidtea mediterranea [PDF]
Stem Cell Reports, 2014 Planarians can regenerate any missing body part in a process requiring dividing cells called neoblasts. Historically, neoblasts have largely been considered a homogeneous stem cell population.
M. Lucila Scimone +3 more
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Regeneration in the absence of canonical neoblasts in an early branching flatworm [PDF]
Nature CommunicationsThe remarkable regenerative abilities of flatworms are closely linked to neoblasts – adult pluripotent stem cells that are the only division-competent cell type outside of the reproductive system.
Ludwik Gąsiorowski +7 more
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Protein Core Fucosylation Regulates Planarian Head Regeneration via Neoblast Proliferation [PDF]
Frontiers in Cell and Developmental Biology, 2021 Protein glycosylation is an important posttranslational modification that plays a crucial role in cellular function. However, its biological roles in tissue regeneration remain interesting and primarily ambiguous.
Wenjun Wang +14 more
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Extracellular Vesicles Derived From Regenerating Tissue Promote Stem Cell Proliferation in the Planarian Schmidtea mediterranea [PDF]
Journal of Extracellular BiologyExtracellular vesicles (EVs) are secreted nanoparticles composed of a lipid bilayer that carry lipid, protein, and nucleic acid cargo between cells as a mode of intercellular communication.
Priscilla N. Avalos Najera +2 more
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Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians [PDF]
HeliyonRegeneration is the ability to accurately regrow missing body parts. The unparalleled regenerative capacity and incredible tissue plasticity of planarians, both resulting from the presence of abundant adult stem cells referred to as neoblasts, offer a ...
Xuhui Chen
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Stimulating Neoblast-Like Cell Proliferation in Juvenile Fasciola hepatica Supports Growth and Progression towards the Adult Phenotype In Vitro. [PDF]
PLoS Neglected Tropical Diseases, 2016 Fascioliasis (or fasciolosis) is a socioeconomically important parasitic disease caused by liver flukes of the genus Fasciola. Flukicide resistance has exposed the need for new drugs and/or a vaccine for liver fluke control.
Paul McCusker +11 more
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What role do annelid neoblasts play? A comparison of the regeneration patterns in a neoblast-bearing and a neoblast-lacking enchytraeid oligochaete. [PDF]
PLoS ONE, 2012 The term 'neoblast' was originally coined for a particular type of cell that had been observed during annelid regeneration, but is now used to describe the pluripotent/totipotent stem cells that are indispensable for planarian regeneration.
Maroko Myohara
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Neoblast-enriched zinc finger protein FIR1 triggers local proliferation during planarian regeneration [PDF]
Protein & Cell, 2018 Regeneration, relying mainly on resident adult stem cells, is widespread. However, the mechanism by which stem cells initiate proliferation during this process in vivo is unclear.
Xiao-Shuai Han +6 more
doaj +4 more sources
Transcriptional signatures of somatic neoblasts and germline cells in Macrostomum lignano
eLife, 2016 The regeneration-capable flatworm Macrostomum lignano is a powerful model organism to study the biology of stem cells in vivo. As a flatworm amenable to transgenesis, it complements the historically used planarian flatworm models, such as Schmidtea ...
Magda Grudniewska +9 more
doaj +6 more sources
Stochastic cell-intrinsic stem cell decisions control colony growth in planarians [PDF]
eLifeStem cells contribute to organismal homeostasis by balancing division, self-renewal, and differentiation. Elucidating the strategies by which stem cells achieve this balance is critical for understanding homeostasis and for addressing pathogenesis ...
Tamar Frankovits +4 more
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