Decreased neoblast progeny and increased cell death during starvation-induced planarian degrowth [PDF]
The International Journal of Developmental Biology, 2012 The development of a complex multicellular organism requires a careful coordination of growth, cell division, cell differentiation and cell death. All these processes must be under intricate and coordinated control, as they have to be integrated across all tissues.
Cristina González‐Estévez +3 more
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Open Biology, 2023 Adult planarians can regenerate the gut, eyes and even a functional brain. Proper identity and patterning of the newly formed structures require signals that guide and commit their adult stem cells.
M. Dolores Molina +4 more
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Identification of neoblast- and regeneration-specific miRNAs in the planarian Schmidtea mediterranea [PDF]
RNA, 2013 In recent years, the planarian Schmidtea mediterranea has emerged as a tractable model system to study stem cell biology and regeneration. MicroRNAs are small RNA species that control gene expression by modulating translational repression and mRNA stability and have been implicated in the regulation of various cellular processes.
Vidyanand Sasidharan +8 more
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Regeneration of Planarian Auricles and Reestablishment of Chemotactic Ability
Frontiers in Cell and Developmental Biology, 2021 Detection of chemical stimuli is crucial for living systems and also contributes to quality of life in humans. Since loss of olfaction becomes more prevalent with aging, longer life expectancies have fueled interest in understanding the molecular ...
Eugene Matthew P. Almazan +3 more
doaj +1 more source
Melt-enhanced strain localization and phase mixing in a large-scale mantle shear zone (Ronda peridotite, Spain) [PDF]
Solid Earth, 2023 Strain localization in upper-mantle shear zones by grain size reduction and the activation of grain-size-sensitive deformation mechanisms is closely linked to phase mixing.
S. Tholen +3 more
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A lineage CLOUD for neoblasts [PDF]
Seminars in Cell & Developmental Biology, 2019 In planarians, pluripotency can be studied in vivo in the adult animal, making these animals a unique model system where pluripotency-based regeneration (PBR)-and its therapeutic potential-can be investigated. This review focuses on recent findings to build a cloud model of fate restriction likelihood for planarian stem and progenitor cells.
Thao Anh, Tran, Luca, Gentile
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Role of neoblasts in the patterned postembryonic growth of the platyhelminth Macrostomum lignano [PDF]
Neurogenesis, 2018 Neoblasts are motile pluripotent stem cells unique to the flatworm phyla Platyhelminthes and Acoela. The role of neoblasts in tissue regeneration has received much attention in recent studies. Here we review data pertinent to the structure and embryonic origin of these stem cells, and their participation in normal cell turnover.
Maria Del Mar De Miguel-Bonet +2 more
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Egf Signaling Directs Neoblast Repopulation by Regulating Asymmetric Cell Division in Planarians [PDF]
Developmental Cell, 2016 A large population of proliferative stem cells (neoblasts) is required for physiological tissue homeostasis and post-injury regeneration in planarians. Recent studies indicate that survival of a few neoblasts after sublethal irradiation results in the clonal expansion of the surviving stem cells and the eventual restoration of tissue homeostasis and ...
Kai Lei +8 more
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Prospectively Isolated Tetraspanin+ Neoblasts Are Adult Pluripotent Stem Cells Underlying Planaria Regeneration [PDF]
Cell, 2018 Proliferating cells known as neoblasts include pluripotent stem cells (PSCs) that sustain tissue homeostasis and regeneration of lost body parts in planarians. However, the lack of markers to prospectively identify and isolate these adult PSCs has significantly hampered their characterization.
An Zeng +18 more
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The exceptional stem cell system of Macrostomum lignano : screening for gene expression and studying cell proliferation by hydroxyurea treatment and irradiation [PDF]
, 2007 BackgroundFlatworms are characterized by an outstanding stem cell system. These stem cells (neoblasts) can give rise to all cell types including germ cells and power the exceptional regenerative capacity of many flatworm species.
Pfister, Daniela +8 more
core +2 more sources