Results 51 to 60 of about 1,704 (212)

Clonogenic Neoblasts Are Pluripotent Adult Stem Cells That Underlie Planarian Regeneration [PDF]

Science, 2011
A pluripotent adult stem cell underlies flatworms’ amazing regenerative ability.
Daniel E. Wagner, Irving E. Wang, Peter W. Reddien   +2 more
  +8 more sources

Tissue absence initiates regeneration through Follistatin-mediated inhibition of Activin signaling [PDF]

, 2013
Regeneration is widespread, but mechanisms that activate regeneration remain mysterious. Planarians are capable of whole-body regeneration and mount distinct molecular responses to wounds that result in tissue absence and those that do not.
Castresana, Eisenhoffer, Gaviño, Gurley, Hayashi, Hemmati-Brivanlou, Higgins, Ho, Huelsenbeck, Hübner, Jaźwińska, Kogure, Kojima, Lapan, Liu, Lévesque, Molina, Molina, Morgan, Mustoe, Nakamura, Newmark, Orii, Pearson, Pellettieri, Petersen, Reddien, Reddien, Reddien, Reddien, Roberts-Galbraith, Romero-Gallo, Ronquist, Russell, Sakami, Sandmann, Scimone, Sulyok, Sánchez Alvarado, Thompson, Wagner, Wenemoser, Wenemoser, Zhu   +43 more
core   +4 more sources

Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the host liver

BMC Genomics, 2021
Background The major pathogenesis associated with Fasciola hepatica infection results from the extensive tissue damage caused by the tunnelling and feeding activity of immature flukes during their migration, growth and development in the liver.
Krystyna Cwiklinski, Mark W. Robinson, Sheila Donnelly, John P. Dalton   +3 more
doaj   +1 more source

Transcriptional signatures of somatic neoblasts and germline cells in Macrostomum lignano [PDF]

, 2009
The regeneration-capable flatworm Macrostomum lignano is a powerful model organism to study the biology of stem cells in vivo. As a flatworm amenable to transgenesis, it complements the historically used planarian flatworm models, such as Schmidtea ...
Grudniewska, M., Mouton, S., Simanov, D., Beltman, F., Grelling, M., De Mulder, K., Arindrarto, W., Weissert, P.M., van der Elst, S., Berezikov, E.   +9 more
core   +1 more source

Genome and transcriptome of the regeneration-competent flatworm, Macrostomum lignano. [PDF]

, 2015
The free-living flatworm, Macrostomum lignano has an impressive regenerative capacity. Following injury, it can regenerate almost an entirely new organism because of the presence of an abundant somatic stem cell population, the neoblasts.
Battistoni, Giorgia, Delás, M Joaquina, El Demerdash, Osama, Falciatori, Ilaria, Gurtowski, James, Hannon, Gregory J, Ladurner, Peter, McCombie, W Richard, Ramos, Olivia Mendivil, Schatz, Michael, Schärer, Lukas, Smith, Andrew D, Vizoso, Dita B, Wasik, Kaja, Zhou, Xin   +14 more
core   +2 more sources

Neoblast-like stem cells of Fasciola hepatica

PLOS Pathogens, 2023
The common liver fluke (Fasciola hepatica) causes the disease fasciolosis, which results in considerable losses within the global agri-food industry. There is a shortfall in the drugs that are effective against both the adult and juvenile life stages within the mammalian host, such that new drug targets are needed.
Paul McCusker, Nathan Clarke, Erica Gardiner, Rebecca Armstrong, Erin McCammick, Paul McVeigh, Emily Robb, Duncan Wells, Madelyn Nowak-Roddy, Abdullah Albaqami, Angela Mousley, Jonathan A. Coulter, John Harrington, Nikki J. Marks, Aaron G. Maule   +14 more
openalex   +5 more sources

The pioneer factor Smed-gata456-1 is required for gut cell differentiation and maintenance in planarians [PDF]

, 2018
How adult stem cells differentiate into different cell types remains one of the most intriguing questions in regenerative medicine. Pioneer factors are transcription factors that can bind to and open chromatin, and are among the first elements involved ...
Adell i Creixell, Teresa, González Sastre, Alejandro, Saló i Boix, Emili, Sousa, Nidia De   +3 more
core   +1 more source

On the trail of a tropical disease

eLife, 2013
Learning more about the cells that enable parasitic worms called schistosomes to reproduce inside snails could lead to new treatments that prevent these parasites from being transmitted to humans.
Alejandro Sánchez Alvarado
doaj   +1 more source

Outstanding intraindividual genetic diversity in fissiparous planarians (Dugesia, Platyhelminthes) with facultative sex.

, 2019
Predicted genetic consequences of asexuality include high intraindividual genetic diversity (i.e., the Meselson effect) and accumulation of deleterious mutations (i.e., Muller’s Ratchet), among others.
Leria, L., Riutort, M., Solà, E., Vila Farre, M.   +3 more
core   +1 more source

Canonical and early lineage-specific stem cell types identified in planarian SirNeoblasts

Cell Regeneration, 2021
Background The pluripotent stem cells in planarians, a model for tissue and cellular regeneration, remain further identification. We recently developed a method to enrich piwi-1+ cells in Schmidtea mediterranea, by staining cells with SiR-DNA and Cell ...
Kaimeng Niu, Hao Xu, Yuanyi Zhou Xiong, Yun Zhao, Chong Gao, Chris W. Seidel, Xue Pan, Yuqing Ying, Kai Lei   +8 more
doaj   +1 more source