Results 151 to 160 of about 691,594 (323)

Continuous non-contact vital sign monitoring of neonates in intensive care units using RGB-D cameras [PDF]

open access: yesarXiv
Neonates in intensive care require continuous monitoring. Current measurement devices are limited for long-term use due to the fragility of newborn skin and the interference of wires with medical care and parental interactions. Camera-based vital sign monitoring has the potential to address these limitations and has become of considerable interest in ...
arxiv  

Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao   +7 more
wiley   +1 more source

The molecular genetics of RASopathies: An update on novel disease genes and new disorders

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 190, Issue 4, Page 425-439, December 2022., 2022
Abstract Enhanced signaling through RAS and the mitogen‐associated protein kinase (MAPK) cascade underlies the RASopathies, a family of clinically related disorders affecting development and growth. In RASopathies, increased RAS‐MAPK signaling can result from the upregulated activity of various RAS GTPases, enhanced function of proteins positively ...
Marco Tartaglia   +2 more
wiley   +1 more source

EchoSim4D: A Proof-of-Concept Gamified XR Echocardiography Training Simulator for Neonates using 4D Ultrasound Volume [PDF]

open access: yesarXiv
Neonatal echocardiography is vital for early detection of heart anomalies in newborns, enabling timely, non-invasive interventions where 4D ultrasound, adds the dimension of time to 3D imaging, enhances diagnostic capabilities by visualizing real-time heart dynamics.
arxiv  

LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

open access: yesAdvanced Science, EarlyView.
This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao   +15 more
wiley   +1 more source

Clinical overview on RASopathies

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 190, Issue 4, Page 414-424, December 2022., 2022
Abstract RASopathies comprise a group of clinically overlapping developmental disorders caused by genetic variations affecting components or modulators of the RAS‐MAPK signaling cascade, which lead to dysregulation of signal flow through this pathway.
Martin Zenker
wiley   +1 more source

Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
This study has unveiled significant new insights into the role of MS4A4A in Alzheimer's disease‐related epilepsy, highlighting its impact on microglial phagocytosis, mitochondrial metabolism, and cytoskeleton, and demonstrating its therapeutic potential in epilepsy management.
Meng Jiang   +10 more
wiley   +1 more source

Vision-language models for decoding provider attention during neonatal resuscitation [PDF]

open access: yesarXiv
Neonatal resuscitations demand an exceptional level of attentiveness from providers, who must process multiple streams of information simultaneously. Gaze strongly influences decision making; thus, understanding where a provider is looking during neonatal resuscitations could inform provider training, enhance real-time decision support, and improve the
arxiv  

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