Results 81 to 90 of about 308,656 (184)

Metformin Inhibits Trophoblast Ferroptosis by Suppressing ATF2 and Activating the PI3K/Akt/Nrf2 Pathway to Improve Gestational Diabetes Mellitus

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Metformin suppresses ATF2 expression, activating the PI3K/Akt pathway and promoting Nrf2 nuclear translocation. This upregulates GPX4, inhibiting ferroptosis in trophoblast cells. Erastin blocks system Xc−, depleting GSH and promoting ferroptosis. LY294002 and ML385 inhibit the pathway, validating the mechanism.
Dandan Xia, Yuhui Zhang, Wenjie Liu, Siyu Li, Chenying Zhang, Guangtong She, Huiyan Wang   +6 more
wiley   +1 more source

UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 2986-3001, September 2026.
Abstract Irinotecan, a topoisomerase I inhibitor, is available as both non‐pegylated and pegylated formulations. The non‐pegylated formulation is licensed for use in advanced colorectal cancer either in combination with other agents or as monotherapy.
Dharmisha Chauhan, Cinzia Dello Russo, Jack Thompson, Dyfrig A. Hughes, Katherine Payne, Maria Tsakiroglou, Paul Ross, Rena Chauhan, Simon Jenkinson, Jessica Keen, Sophie Harding, Eleanor Lau, Michael Braun, Roshan Agarwal, Richard Adams, Elisabeth Rolf, Farah Al‐Sheikhli, Sarah Mitchell, Ruth Hammond, Rosie Roberts, Lorna Cairns, Shirley Heggarty, Janet Graham, Justin Mencel, Munir Pirmohamed   +24 more
wiley   +1 more source

FREQUENCY OF NEONATAL HYPERBILIRUBINEMIA AND ITS OUTCOME AFTER TREATMENT

, 2017
Objective: The objective of this study was to find out the prevalence and outcome after treatment of in neonatal hyperbilirubinemia. Material & Methods: This descriptive study was conducted in the department of LUMH.
Dr. Abdul Rehman Siyal, Dr. Khalid Yousuf Memon, Dr. Hemandas, Munawar Ali Kalhoro
core   +1 more source

G6PD genetic variations in neonatal Hyperbilirubinemia in Indonesian Deutromalay population [PDF]

, 2019
Background: Neonatal jaundice is a common finding in newborns in Asia, including Indonesia. In some cases, the serum total bilirubin levels exceeds the 95th percentile for hours of life (neonatal hyperbilirubinemia).
Porsch, R.M. (Robert M.), Asni, E.K. (Eni K.), Wisnumurti, D.A. (Dewi A.), IJcken, W.F.J. (Wilfred) van, Achmad, T.H. (Tri H.), Rahayuningsih, S.E. (Sri E.), Sleutels, F. (Frank), Sribudiani, Y. (Yunia), Maskoen, A.M. (Ani M.), Sukadi, A. (Abdurachman)   +9 more
core   +1 more source

Effects of variation status and enzyme activity for UDP-glucuronosyltransferase 1A1 gene on neonatal hyperbilirubinemia

Pediatrics and Neonatology, 2020
Background: We found that Taiwanese adults carrying genotypes of UDP-glucuronosyltransferase (UGT) 1A1 with enzyme activity ≤40% of normal were at high risk for developing Gilbert's syndrome. However, the relationship between UGT1A1 activity and neonatal
May-Jen Huang, Yu-Cheng Lin, Kevin Liu, Pi-Feng Chang, Ching-Shan Huang   +4 more
doaj   +1 more source

Incidence and causes of neonatal hyperbilirubinemia in a center of Catania

, 2009
Marco Sciuto1, Gaetano Bertino2, Mariangela Zocco3, Ignazio Vecchio4, Rocco Raffaele4, Rosario R Trifiletti5, Piero Pavone3,61Neonatal Care Section, Valsalva Hospital, Catania, Italy; 2Department of Internal Medicine, Hospital S Marta University of ...
Gaetano Bertino, Ignazio Vecchio, Mariangela Zocco, et al., Marco Sciuto   +4 more
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Oxidative stress and antioxidant status in neonatal hyperbilirubinemia

, 2008
Conclusions: In this sample, infants with significant hyperbilirubinemia had elevated oxidative stress and disturbed antioxidant enzyme activity.
Ergul B. Kurutas, Mesut Garipardic, Mehmet Davutoglu, Ekerbiçer, Hasan Çetin, Hamza Karabiber, Ekrem Guler, Seref Olgar   +6 more
core   +1 more source

Systematic Review and Meta-analysis of Neonatal Hyperbilirubinemia in Ethiopia

Neonatal hyperbilirubinemia is a common neonatal disorder worldwide and represents an important contributor to newborn morbidity, especially in low- and middle-income countries such as Ethiopia. Although multiple primary studies have
Shambel Negese, Gada Edea, Bacha Chuko, Fikru Assefa, Nebiyu Taye, Girma Teferi, Zufela Sime, Derara Kebata   +7 more
core   +1 more source

Profile of infants admitted for significant neonatal hyperbilirubinemia.

, 2016
Profile of infants admitted for significant neonatal hyperbilirubinemia.
Bolajoko O. Olusanya (692132), Zainab O. Imam (2579551), Abieyuwa A. Emokpae (2579557), Cecilia A. Mabogunje (2579554)   +3 more
core   +1 more source

Genetic factors in neonatal hyperbilirubinemia and kernicterus [PDF]

, 2007
Although the relationship between hyperbilirubinemia and genetic factors has long been questioned, the role of genetic factors in the development of severe hyperbilirubinemia and kernicterus has been investigated in detail in the last decade with the ...
Mehmet Saldir, S Umit Sarici
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