Results 91 to 100 of about 1,812,268 (301)

Pediatric and Neonatal Surgery

, 2017
Neonatal and Pediatric Surgery is a broad field with many challenges. The aim of this short book is to provide the reader with several informative chapters in the field of neonatal and pediatric surgery.

core   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Association Between Perioperative Inflammatory Trajectories and Postoperative Hirschsprung-Associated Enterocolitis: Insights from Group-Based Trajectory Modeling

Journal of Inflammation Research
Zhengxing Jiang, Wei Feng, Hongtao Hu, Xiaoping Wei, Yinuo Jiang, Jinping Hou, Yi Wang Department of General and Neonatal Surgery, Children’s Hospital of Chongqing Medical University; National Clinical Research Center for Child Health and Disorders ...
Jiang Z, Feng W, Hu H, Wei X, Jiang Y, Hou J, Wang Y   +6 more
doaj  

Transumbilical Laparoscopic-Assisted (TULA) Surgery for Treating Abdominal Pathologies in Newborns: A Retrospective Single-Center Experience

Children
Background: Transumbilical laparoscopic-assisted (TULA) surgery is a minimally invasive technique that combines laparoscopic exploration with extracorporeal surgical management, offering potential advantages in neonatal abdominal surgery.
Giada Loria, Roberta Aurora Aversa, Alessandra Fichera, Agnese Bartolone, Vincenzo Di Benedetto, Maria Grazia Scuderi   +5 more
doaj   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Laparoscopic treatment of patent omphalomesenteric duct: a new surgical approach

World Journal of Pediatric Surgery, 2023
Bo Li, Ming Li, Yong Feng, Chanjuan Zou, Yong Xiao, Guang Xu, Renpeng Xia, Chonggao Zhou   +7 more
doaj   +1 more source

Prenatal MRI Detection of Fetal Small Intestinal Volvulus: The Black‐and‐White and Coffee‐Bean Signs

Clinical Case Reports
A rare case of fetal small intestinal volvulus was diagnosed prenatally using MRI, with characteristic black‐and‐white and coffee‐bean signs. Early diagnosis led to timely surgical intervention and a favorable outcome.
Miyu Nakamura, Hiroshi Sato, Kazuyo Kakui   +2 more
doaj   +1 more source

Retrospective Analysis of Neonatal Surgery at Tottori University over the Past Ten Years. [PDF]

Yonago Acta Med, 2023
Hasegawa T, Takano S, Masuda K, Fujiwara Y, Miyahara A, Miura M.   +5 more
europepmc   +1 more source