Results 71 to 80 of about 1,812,268 (301)

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

Experience in the treatment of type C congenital esophageal atresia using a staged approach

BMC Surgery
Background In select patients with type C esophageal atresia, primary anastomosis is not appropriate and a staged approach is required. We aim to summarize our experience in the management of type C EA using a staged approach.
Yong Zhao, Shihui Tan, An Wang, Shuangshuang Li, Junmin Liao, Dingding Wang, Kaiyun Hua, Yichao Gu, Yanan Zhang, Jinshi Huang   +9 more
doaj   +1 more source

Increasing adoption of minimally invasive surgery for congenital lung malformations in young infants: a single-center experience

Frontiers in Pediatrics
ObjectivesCongenital lung malformations (CLM) encompass a heterogeneous group of conditions increasingly diagnosed prenatally. While surgical resection is widely adopted, the surgical approach is progressively shifting toward minimally invasive ...
Rebecca Pulvirenti, Laura Valfrè, Martina Capitani, Federico Beati, Federico Scorletti, Chiara Iacusso, Barbara Daniela Iacobelli, Fabio Fusaro, Pietro Bagolan, Andrea Conforti   +9 more
doaj   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

The gut microbiota-bile acid axis in cholestatic liver disease

Molecular Medicine
Cholestatic liver diseases (CLD) are characterized by impaired normal bile flow, culminating in excessive accumulation of toxic bile acids. The majority of patients with CLD ultimately progress to liver cirrhosis and hepatic failure, necessitating liver ...
Dayan sun, Chuanping Xie, Yong Zhao, Junmin Liao, Shuangshuang Li, Yanan Zhang, Dingding Wang, Kaiyun Hua, Yichao Gu, Jingbin Du, Guoxian Huang, Jinshi Huang   +11 more
doaj   +1 more source

Higher Programmatic Volume in Neonatal Heart Surgery Is Associated With Lower Early Mortality

, 2018
Background. The early results of congenital heart surgery in neonates remain a challenge. We sought to determine the nature of the association between annual center volume of neonatal cardiac surgery and operative mortality using a multicenter cohort ...
Tobota, Zdzislaw, Christine zu Eulenburg, Zu Eulenburg, C, Georgios Sarris, Tobota, Z, Tjark Ebels, Jacobs, Jeffrey P., Sarris, Georgios, Ebels, Tjark, Fragata, J, Maruszewski, Bohdan, Ebels, Tjark; id_orcid, Kansy, A, Bohdan Maruszewski, zu Eulenburg, Christine, Kansy, Andrzej, Eulenburg, Christine Zu, Zdzislaw Tobota, Ebels, T, Maruszewski, B, Jeffrey P. Jacobs, Fragata, Jose, Sarris, G, Andrzej Kansy, Jose Fragata, Jacobs, JP   +25 more
core   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

The intraoperative localization in recurrent tracheoesophageal fistula after esophageal atresia repair: a comparative study

BMC Pediatrics
Background Recurrent tracheoesophageal fistula (rTEF) is a rare complication following initial esophageal atresia (EA) surgical repair, posing challenges in localization the fistula during surgery due to severe thoracic adhesions and structural ambiguity
Kaiyun Hua, Junmin Liao, Dayan Sun, Dingding Wang, Yong Zhao, Yichao Gu, Shuangshuang Li, Peize Wang, Yanan Zhang, Jinshi Huang   +9 more
doaj   +1 more source

Maternal tetanus toxoid vaccination and neonatal mortality in rural North India [PDF]

, 2015
Objectives: Preventable neonatal mortality due to tetanus infection remains common. We aimed to examine antenatal vaccination impact in a context of continuing high neonatal mortality in rural northern India.
Singh, Abhishek, William Stones, Ogollah, Reuben, Stones, William, Reuben Ogollah, Pallikadavath, Saseendran, Saseendran Pallikadavath, Abhishek Singh   +7 more
core   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source