Results 81 to 90 of about 1,812,268 (301)

Neonatal Perforated Appendicitis Masquerading as Necrotizing Enterocolitis

, 2017
A preterm neonate underwent emergent laparotomy for presumed necrotizing enterocolitis (NEC). Intra-operatively, neonatal perforated appendicitis (NPA) was encountered. This may represent a form of NEC localized to the appendix.
Chotai, Pranit N, James W Eubanks III, Tumen, Andrew, Jie Zhang, Ramesh Krishnan, Adrianne Myers-Webb, Williams, John Matthew, Eubanks Iii, James W, Andrew Tumen, Myers-Webb, Adrianne, Krishnan, Ramesh, Zhang, Jie, Pranit N Chotai, John Matthew Williams   +13 more
core   +1 more source

Sequential Patterning of Photoresponsive Hydrogels Directs Crypt Fission and Reveals the Role of Epithelial Curvature on Fission Symmetry

Advanced Science, EarlyView.
Deterministic crypt fission is achieved in intestinal organoids using photopatternable hydrogels with spatiotemporal control. Daughter‐crypt symmetry is shown to depend on parent‐crypt geometry and epithelial curvature, while myosin‐dependent mechanosensing links tissue shape to regenerative outcomes.
Delaney L. McNally, Kaustav Bera, Nolan R. Petrich, Alex Khang, Marilyne Coulombe, David Castillo‐Azofeifa, Ophir D. Klein, Peter J. Dempsey, Kristi S. Anseth   +8 more
wiley   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Gastroschisis: diagnosis, prognosis and treatment options

Frontiers in Pediatrics
Gastroschisis is a rare congenital anomaly characterized by extrusion of abdominal organs through a defect in the anterior abdominal wall, typically to the right of the umbilical cord.
Dastan Rustemov, Zhenis Sakuov, Zhuldyz Kucherbayeva, Sherkhan Shayakhmetov, Ruslan Bilal   +4 more
doaj   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Is performing the Kasai portoenterostomy in the neonatal period associated with a better prognosis? A single-center, retrospective cohort study from China

BMC Pediatrics
Background/Purpose This study aimed to evaluate discrepancies in prognosis after the Kasai portoenterostomy (KPE) procedure between neonatal and non-neonatal periods among patients undergoing the KPE procedure less than 60 days after birth (≤ 60 days ...
Chuanping Xie, Peize Wang, Dingding Wang, Yuyan Jin, Shuangshuang Li, Yong Zhao, Junmin Liao, Yanan Zhang, Kaiyun Hua, Yichao Gu, Jingbin Du, Yongwei Chen, Dayan Sun, Guojun Zhang, Jinshi Huang   +14 more
doaj   +1 more source

Lung Transplantation for Late-Onset Pulmonary Hypertension in a Patient with Congenital Diaphragmatic Hernia

European Journal of Pediatric Surgery Reports, 2018
Lung hypoplasia and pulmonary hypertension (PH) in association with congenital diaphragmatic hernia (CDH) may cause fatal respiratory failure. Lung transplantation (Ltx) may represent an option for CDH-related end-stage pulmonary failure. The aim of this
Chiara Iacusso, Francesco Morini, Irma Capolupo, Andrea Dotta, Stefania Sgrò, Francesco Parisi, Adriano Carotti, Pietro Bagolan   +7 more
doaj   +1 more source

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

Advanced Science, EarlyView.
Targeted chimeric degraders engage extracellular or membrane proteins and endocytosable cell‐surface receptors, forming ternary complexes that induce receptor‐mediated internalization. Following endocytosis, post‐endocytic sorting—not internalization alone—determines target fate.
Ke Liu, Xiyan Wang, Xiaozhen Liu, Chaoqi He, Da Qian, Xuli Meng, Liquan Zhu   +6 more
wiley   +1 more source

Development of a prediction nomogram for 1-month mortality in neonates with congenital diaphragmatic hernia

BMC Surgery
Objectives Although many prognostic factors in neonates with congenital diaphragmatic hernia (CDH) have been described, no consensus thus far has been reached on which and how many factors are involved. The aim of this study is to analyze the association
Zhong Feng, Yandong Wei, Ying Wang, Chao Liu, Dong Qu, Jingna Li, Lishuang Ma, Wenquan Niu   +7 more
doaj   +1 more source

From colostomy creation to full enteral feeding in neonates with an anorectal malformation: evaluating the role of central venous access

Frontiers in Surgery
PurposeAfter creating a colostomy in newborns with anorectal malformations (ARMs), reaching full enteral feeding may take longer than expected, resulting in an unanticipated period of starvation.
D. Huijgen, I. K. Schokker-van Linschoten, H. P. Versteegh, C. E. J. Sloots   +3 more
doaj   +1 more source