Results 51 to 60 of about 432,494 (360)

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Neurobehavior of term neonates with neonatal hyperbilirubinemia

Journal of Pediatric Neurosciences, 2013
To find the effect of neonatal hyperbilirubinemia on neurobehavior of term infants.This study was undertaken in the neonatal unit of our tertiary care hospital. Term neonates who developed jaundice with serum bilirubin value of above 15 mg/dl within 1(st) week of life were enrolled in the study.
Noyal Mariya Joseph, Thirunavukkarasu Arun Babu, B Vishnu Bhat   +2 more
openaire   +4 more sources

Ohio Conservation Plan, Revised 2019, for the Plains Gartersnake, Thamnophis radix [PDF]

, 2019
This plan outlines strategies and methods used in an ongoing study initiated in 1999 to restore a self- sustaining population of the Plains Gartersnake (Thamnophis radix) in Ohio.
Reichenbach, Norman
core   +1 more source

In Vitro Consequences of Electronic-Cigarette Flavoring Exposure on the Immature Lung. [PDF]

, 2019
Background: The developing lung is uniquely susceptible and may be at increased risk of injury with exposure to e-cigarette constituents. We hypothesize that cellular toxicity and airway and vascular responses with exposure to flavored refill solutions ...
Berkelhamer, Sara, Goniewicz, Maciej, Gugino, Sylvia, Helman, Justin, Lakshminrusimha, Satyanarayana, Leigh, Noel   +5 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Fetal Alcohol Syndrome: a complex case of teratogenic effects of maternal alcohol consumption and clinical managment

Quality in Sport
Introduction and purpose    Maternal alcohol consumption during pregnancy is a well-documented risk factor for adverse fetal outcomes, encompassing a spectrum of disorders known as Fetal Alcohol Spectrum Disorders (FASD).
Sylwia Koziej, Emilia Kowalczyk, Joanna Borkowska, Julia Bajorek   +3 more
doaj   +1 more source

A Case of Misdiagnosed Cesarean Scar Pregnancy with a Viable Birth at 28 Weeks

Case Reports in Obstetrics and Gynecology, 2014
We report our experience with a case of presumptive cesarean scar pregnancy, based on detection of a gestational sac (GS) in early pregnancy at the site of a previous cesarean scar. The GS grew into the uterine cavity as the pregnancy progressed, showing
Sakiko Nukaga, Shigeru Aoki, Kentaro Kurasawa, Tsuneo Takahashi, Fumiki Hirahara   +4 more
doaj   +1 more source

The COVID-19 pandemic impact on the Polish medical personnel work: a survey and in-depth interviews study

Frontiers in Public Health, 2023
ObjectiveThe objective of the study was to examine the impact of the COVID-19 pandemic on the work of medical personnel in terms of: task scope, preparation to perform medical tasks related to the pandemic, team collaboration, involvement in tasks ...
Paweł Przyłęcki, Magdalena Wieczorkowska, Agnieszka Pawlak-Kałuzińska, Wioletta Cedrowska-Adamus, Ewa Gulczyńska   +4 more
doaj   +1 more source

Treatments for women with gestational diabetes mellitus: an overview of Cochrane systematic reviews [PDF]

, 2018
Background Successful treatments for gestational diabetes mellitus (GDM) have the potential to improve health outcomes for women with GDM and their babies. Objectives To provide a comprehensive synthesis of evidence from Cochrane systematic reviews of
Alsweiler, Jane, Brown, Julie, Crowther, Caroline A, Downie, Michelle R, Martis, Ruth, Shepherd, Emily   +5 more
core   +1 more source