Results 151 to 160 of about 241,024 (313)

Bone-derived excess TGF-ß release is associated with cognitive dysfunction due to oxidation of RyR, Ca2+ leak and mitochondrial dysfunction

Journal of Bone Oncology
Lei Shi, Sukanya Suresh, Truc Kuo, Anand Singh, Jade Martinez, Trupti Trivedi, Gabriel M. Pagnotti, Leah D. Guerra, Xu Cao, Theresa A. Guise   +9 more
doaj   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Gut decisions based on the liver: prediction of colorectal neoplasia using AI-based liver analysis of routine CT scans. [PDF]

Front Oncol
Hinterberger A, Bohn J, Trofimova D, Knabe N, Dettling J, Norajitra T, Isensee F, Betge J, Schönberg SO, Nörenberg D, Grosu S, Loges S, Floca R, Kather JN, Maier-Hein K, Grawe F.   +15 more
europepmc   +1 more source

Author Correction: Metabolic factors are associated with a higher risk of conventional adenoma in males during surveillance colonoscopy: findings from a South Australian cohort. [PDF]

Sci Rep
Molla MD, Symonds EL, Winter JM, Cock C, Wassie MM.   +4 more
europepmc   +1 more source

DCLK1 immunoreactivity in colorectal neoplasia

, 2012
Giuseppe Gagliardi1, Monica Goswami1, Roberto Passera2, Charles F Bellows11Department of Surgery and Pathology, Tulane University, New Orleans, LA, USA; 2Division of Nuclear Medicine Azienda Ospedaliero-Universitaria San Giovanni Battista, Turin ...
Bellows CF, Gagliardi G, Passera R, Goswami M   +3 more
core  

Prevention of Myc‐Driven Prostate Cancer in Mice by Oral Administration of Sulforaphane

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention is desirable to reduce suffering and death from prostate cancer. However, a clinical‐grade intervention for the prevention of this malignancy is still lacking. This study was undertaken to determine the feasibility of prostate cancer prevention by broccoli constituent sulforaphane (SFN) because epidemiological studies have suggested
Krishna B. Singh, Eun‐Ryeong Hahm, Bruce L. Jacobs, Shivendra V. Singh   +3 more
wiley   +1 more source

#5. Activating RET mutations in medullary thyroid cancer cells promotes osteoblastic bone metastasis by inhibiting osteoclastogenesis and stimulating osteoblast activity

Journal of Bone Oncology
Rozita Bagheri-Yarmand, Gabriel M Pagnotti, Trupti Trivedi, Leah Guerra, Joseph L. Kidd, Jade A. Martinez, Jian H. Song, Sua-Hwa Lin, Theresa A. Guise   +8 more
doaj   +1 more source

Adenocarcinoma em junção esofagogástrica de um cão

Medicina Veterinária
Tumores esofágicos primários em cães e gatos são raros e os principais tipos nas espécies podem ser epiteliais (papiloma e carcinoma de células escamosas) ou mesenquimais (leiomioma, leiomiossarcoma, fibrossarcoma, osteossarcoma ou sarcomas ...
Maurício Franco Zanette, Juliana Aparecida Bombardelli, Ronaldo Gomes Gargano, Felipe Nunes Felippe, Claudia Kiyomi Minazaki, Alex Junior Souza de Souza   +5 more
doaj  

Development and validation of an artificial intelligence classifier for histologic grading of superficial non-ampullary duodenal epithelial tumors. [PDF]

Endosc Int Open
Yamamoto K, Goto A, Ito S, Hamabe K, Hashimoto S, Nishikawa J, Nakamura K, Kiyotoki S, Shirai Y, Kaino S, Yanai H, Ogihara H, Hamamoto Y, Takami T.   +13 more
europepmc   +1 more source

SURMOUNT‐REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity

Obesity, EarlyView.
ABSTRACT Objective SURMOUNT‐REAL UK will evaluate the effectiveness of tirzepatide when offered in addition to standard‐of‐care (SoC) in adults with Class I obesity (BMI ≥ 30 and ≤ 34.9 kg/m2) and without diabetes in a UK primary care setting. Methods A 5‐year, phase 4, multicenter, open‐label, pragmatic randomized clinical trial is enabled through ...
Martin K. Rutter, Julie Mount, J. Martin Gibson, Joanne Webb, Cheryl Marler, Catherine Reed, Mugdha Gore, Wenyu Ye, Elisa Gomez Valderas, John Wilding, Naveed Sattar, Melanie J. Davies, Kamlesh Khunti, Richard Haynes, Rachel L. Batterham   +14 more
wiley   +1 more source