ABSTRACT Background Familial clustering of testicular germ cell tumour (TGCT) is well‐established, whereas the risk of non‐testicular cancer among relatives remains inconsistent across studies. Objective To evaluate the overall and site‐specific cancer risk among first‐degree relatives and grandparents of TGCT patients compared to cancer‐free controls.
Csilla Krausz +13 more
wiley +1 more source
Erratum: Brem EA, Shieh K, Juarez D, et al. A phase 1 study adding pitavastatin to venetoclax therapy in AML and CLL/SLL: a mechanism-based drug repurposing strategy. <i>Blood Neoplasia</i>. 2024;1(4):100036. [PDF]
europepmc +1 more source
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick +7 more
wiley +1 more source
Age-stratified prevalence of colorectal adenoma and advanced neoplasia in adults aged 18-39 years: a single-center cross-sectional study of 2, 149 colonoscopies. [PDF]
Ding Y, Liu J, Li H, Lin X.
europepmc +1 more source
A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis +3 more
wiley +1 more source
Meta-analysis of PAX1/JAM3 methylation performance in high-risk HPV-positive women. [PDF]
Qi L, Wu Y, Luo M.
europepmc +1 more source
Neoplastic Risk in Patients With Klinefelter Syndrome
ABSTRACT Background Besides gonadal involvement (hypogonadism, male factor infertility, and testicular hypotrophy), patients with Klinefelter syndrome (KS) may suffer from several extra‐gonadic complications, including neoplastic events. Objective The aim of this review is to summarize all major clinical evidence dealing with the association between KS
Andrea Graziani +4 more
wiley +1 more source
Comments on 'Therapeutic efficacy of laser vaporization and conization for high-grade cervical intraepithelial neoplasia'. [PDF]
Fatima E +3 more
europepmc +1 more source

